Results 61 to 70 of about 12,533,127 (227)

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

I₂‑Mediated Oxidative C–N and N–S Bond Formation in Water: A Metal-Free Synthesis of 4,5-Disubstituted/N-Fused 3‑Amino-1,2,4-triazoles and 3‑Substituted 5‑Amino-1,2,4-thiadiazoles

, 2018
An environmentally benign and convenient strategy for the synthesis of 4,5-disubstituted/N-fused 3-amino-1,2,4-triazoles and 3-substituted 5-amino-1,2,4-thiadiazoles from isothiocyanates has been developed.
Nagesh Jatangi (3998549), Mangarao Nakka (546374), Nagaraju Tumula (3998543), Radha Krishna Palakodety (3998546)   +3 more
core   +1 more source

Synthesis and antituberculosis activity of 2-(aryl/alkylamino)-5-(4- aminophenyl)-1,3,4-thiadiazoles and their Schiff bases

, 2006
A series of new Schiff bases were synthesized through the condensation reaction of 1,3,4-thiadiazoles containing a aromatic primary amine and 3-hydroxybenzaldehyde, salicylaldehyde, 5-nitrofurfuraldehyde or 3-nitrobenzaldehyde.

core   +2 more sources

Synthesis and Antimicrobial Activity of Some 2-[(4-Substituted-Phenyl-3-Chloro-Azetidin-2-One)-5-(2'-Methylamino-4-Phenyl-1', 3'-Thiazolyl-]-1, 3,4-Thiadiazoles [PDF]

Journal of Sciences, Islamic Republic of Iran, 2009
A new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n)
S.D. Srivastava
doaj  

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences, 2012
Two series of novel quinoline derivatives; oxadiazolyl and thiadiazolyl quinolines were prepared and evaluated for their antimicrobial activities. The first series; 5-(2-aryl-6-substituted-4-quinolyl)-1.3,4-oxadiazol-2-amines (Va-g) was synthesized by ...
Lobna Abdel-Aziz , Kamel Metwaly , El-Sayed Lashine , Rania Badawy   +3 more
doaj   +1 more source

Band Engineering of Benzothiadiazole‐Derived Metal‐Organic Frameworks for Photocatalytic Organic Transformations

National Materials, EarlyView.
BTID‐functionalized metal‐organic frameworks provide a modular platform for tailoring photocatalytic electronic structures through acceptor‐linker engineering. By correlating band alignment, charge‐transfer characteristics, and reactive oxygen species generation, this review highlights design principles that enable efficient visible‐light‐driven ...
Xin Li, Long‐Shuang Chen, Meng‐Hao Li, Ying‐Wei Yang   +3 more
wiley   +1 more source

Synthesis and antioxidant activity of styryl-1,3,4-thiadiazoles, pyrazolyl-1,3,4-thiadiazoles and isoxazolyl-1,3,4-thiadiazoles [PDF]

, 2017
325-333A new class of sulfonamido methyl linked styrylsulfonylmethyl-1,3,4-thiadiazoles, pyrazolyl and isoxazolyl 1,3,4-thiadiazoles have been synthesized from the synthetic intermediate 2-(arylaminosulfonylmethyl)-5- (Z-(styrylsulfonylmethyl))-1,3,4 ...
Padmavathi, V, Durgamma, S, Padmaja, A, Yamini, G, Syamaiah, K, Reddy, G Mallikarjuna   +5 more
core  

Synthesis of 4-thioacetyl-1,2,3-thiadiazoles. Reversible rearrangement of N-Substituted 5-methyl-1,2,3-thiadiazole-4-carbothioamides

, 2012
The equilibrium in the reversible rearrangement of 5-methyl-1,2,3- thiadiazole-4-carbothioamides into 5-amino-4-thioacetyl-1,2,3-thiadiazoles is displaced toward the former, and polar solvents favor increased fraction of the thioketone.
Prokhorova, P. E., Morzherin, Yu. Yu., Glukhareva, T. V., Kalinina, T. A.   +3 more
core   +1 more source