Results 61 to 70 of about 9,296,901 (229)

Functionalization of 2-Mercapto-5-methyl-1,3,4-thiadiazole: 2-(ω-Haloalkylthio) Thiadiazoles vs. Symmetrical Bis-Thiadiazoles. [PDF]

Molecules
A study on the functionalisation of 2-mercapto-5-methyl-1,3,4-thiadiazole has been conducted, yielding two series of products: 2-(ω-haloalkylthio)thiadiazoles and symmetrical bis-thiadiazoles, with variable chain lengths.
Petkova ZS, Rusew RI, Shivachev BL, Kurteva VB.   +3 more
europepmc   +2 more sources

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

Journal of Heterocyclic Chemistry, EarlyView.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad, Chithaluri Sudhakar, Vijaya Krishna Ravi, Bijaya Kethan Sahoo   +3 more
wiley   +1 more source

Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo(3,4-b)-1,3, 4-thiadiazoles

, 2022
4-Amino-5aryl/heteroaryl substituted 3-mercapto-1,2,4-triazoles, have been prepared from the corresponding aromatic carboxylic acid through a multistep sequence.
Kumar, Dhirendra ; Department of Chemistry, S. M. M. T.D. College, Ballia, India, Prasad, Subedar ; Department of Chemistry, S. M. M. T.D. College, Ballia, India, Prasad, Akhilesh ; Department of Chemistry, S. M. M. T.D. College, Ballia, India, Gupta, Chitrasen ; Department of Chemistry, Kutir Post Graduate College, Chakkey, Jaunpur, India, Pandey, Avanish Kumar; Department of Chemistry, S. M. M. T.D. College, Ballia, India   +4 more
core   +1 more source

Substituent Effect on the Absorption Spectra of Mesoionic 1, 3, 4-Thiadiazoles

, 1969
Substituent Effect on the Absorption Spectra of Mesoionic 1, 3, 4 ...
P. B. Talukdar, S. K. Sengupta
openaire   +1 more source

Smart molecular design of NIR‐II organic fluorophores through self‐driven iterative evolution, deep learning, and fragment‐based assembly

Smart Molecules, EarlyView.
A smart design strategy for NIR‐II organic fluorophores is proposed by combining self‐driven Iterative evolution, deep Learning, and fragment‐based assembly. This work establishes a broadly applicable approach for molecular design, accelerating the discovery of NIR‐II fluorophores and extending to optoelectronic materials and therapeutic compounds ...
Yu Zhang, Zhubin Hu, Xinyuan Wang, Zhenrong Sun, Yongye Liang, Cheng Zhong, Haitao Sun   +6 more
wiley   +1 more source

Synthesis and antioxidant activity of styryl-1,3,4-thiadiazoles, pyrazolyl-1,3,4-thiadiazoles and isoxazolyl-1,3,4-thiadiazoles [PDF]

, 2017
325-333A new class of sulfonamido methyl linked styrylsulfonylmethyl-1,3,4-thiadiazoles, pyrazolyl and isoxazolyl 1,3,4-thiadiazoles have been synthesized from the synthetic intermediate 2-(arylaminosulfonylmethyl)-5- (Z-(styrylsulfonylmethyl))-1,3,4 ...
Padmavathi, V, Durgamma, S, Padmaja, A, Yamini, G, Syamaiah, K, Reddy, G Mallikarjuna   +5 more
core  

A New Synthesis of Benzo[b]thiophene-2-thiolates and Their Derivatives via Base-Promoted Transformation of 4‑(2-Mercaptophenyl)-1,2,3-thiadiazoles

, 2016
A reaction of 4-(2-mercaptophenyl)-1,2,3-thiadiazoles with an oxidant in the presence of 1.1 equiv of base afforded good yields of benzo[4,5]thieno[3,2-d][1,2,3]thiadiazoles via the intramolecular oxidative nucleophilic substitution of a hydrogen (ONHS ...
Dmitry A. Androsov (1930636), Fedor S. Teplyakov (1930642), Mikhail L. Petrov (1930633), Tatiana G. Vasileva (1930639)   +3 more
core   +1 more source

Synthesis and Antimicrobial Activity of Some 2-[(4-Substituted-Phenyl-3-Chloro-Azetidin-2-One)-5-(2'-Methylamino-4-Phenyl-1', 3'-Thiazolyl-]-1, 3,4-Thiadiazoles [PDF]

Journal of Sciences, Islamic Republic of Iran, 2009
A new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n)
S.D. Srivastava
doaj  

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BMC Cancer, 2017
Background Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer ...
C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa   +9 more
doaj   +1 more source

Complex multitrophic species interactions and fitness costs: Intricate consequences of jasmonate and salicylate induced plant defences

Journal of Animal Ecology, EarlyView.
This study reveals how long‐term activation of jasmonic and salicylic acid signalling reshapes arthropod communities and plant fitness across seasons. By showing that induced defences generate contrasting outcomes and cascading trade‐offs across trophic levels, it challenges the assumption that induced resistance is uniformly beneficial in natural ...
Mônica F. Kersch‐Becker, Guilherme P. Pinheiro, Thaís S. Schweller, Martin Pareja, Victoria M. Pocius, José R. Trigo, Gustavo Q. Romero   +6 more
wiley   +1 more source