Results 81 to 90 of about 12,533,127 (227)
, 2016 A reaction of 4-(2-mercaptophenyl)-1,2,3-thiadiazoles with an oxidant in the presence of 1.1 equiv of base afforded good yields of benzo[4,5]thieno[3,2-d][1,2,3]thiadiazoles via the intramolecular oxidative nucleophilic substitution of a hydrogen (ONHS ...
Dmitry A. Androsov (1930636) +3 more
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Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova +3 more
wiley +1 more source
The efficient synthesis of γ-thiapyrones by a base-mediated Diels–Alder/retro-Diels–Alder reaction of α-pyrones with 5-H-1,2,3-thiadiazoles is reported herein.
Bin Huang (331329) +3 more
core +1 more source
, 2013 Summarization: Upon reaction of 4,5-disubstituted-N-arylaminoimidazole-2-thiones with isocyanides in the presence of azodicarboxylates (1.2 equiv) at rt, the imidazo[2,1-b][1,3,4]thiadiazoles were formed as the only reaction products in very good yields,
Gernot Buth +12 more
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Cumhuriyet Science Journal, 2018 1,3,4-Thiadiazoles have a variety of biologicalactivities depending on their substituents. This study aims to investigatethe in vitro antioxidant properties of 1R,2R-1,2-bis- (5- (4-hydroxynaphthalen-1-ylazo) - [1,3,4] thiadiazol-2-yl) -ethane- 1,2-diole
Akif Evren Parlak, Pelin Koparır
doaj +1 more source
Synthesis and Preliminary Antimicrobial Study of 2-Amino-5-Mercapto-1,3,4-Thiadiazole Derivatives
Iraqi Journal of Pharmaceutical Sciences, 2017 Nitrogen heterocycles are of a special interest because they constitute an important class of natural and non natural products, many of which exhibit useful biological activities.Among these nitrogen heterocycles are 1, 3, 4-thiadiazole containing ...
Husam A. Ameen, Ahlam J. Qasir
doaj +3 more sources
DESIGN, SYNTHESIS AND ANTIFUNGAL EVALUATION OF NOVEL SUBSTITUTED 1, 3, 4-OXADIAZOLES, AND 1, 3, 4-THIADIAZOLES [PDF]
, 2015 Objective: The purpose of this research is to evaluate the antifungal activity of synthesized conjugates of thiophene with 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles using in vitro methods.Methods: The series of (IVa-e) and (Va-e) compounds were ...
Mishra, Pradeep, Upadhyay, Prabhat K
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[O─I─O]+ Halogen‐Bonded Complexes of Pyridine N‐Oxides
Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.The missing puzzle of 3‐center‐4‐electron halogen‐bonded complexes viz. [O─I─O]+ of pyridine N‐oxides are structurally characterized by x‐ray diffraction. Monodentate N‐oxide O‐atom acts as the halogen bond acceptor. Their solution complexations are characterized by 15N NMR spectroscopy.
Rakesh Puttreddy +3 more
wiley +2 more sources
Journal of Saudi Chemical SocietyThe designed and synthesized multifunctional properties of bis-hydrazono[1,3,4]thiadiazoles became important for developing an efficient medication for Alzheimer’s disease.
Reem A.K. Alharbi +3 more
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3-(2-Fluorophenyl)-6-(phenoxymethyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
Acta Crystallographica Section E, 2008 The crystal structure of the title compound, C16H11FN4OS, was synthesized in the course of our studies on 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles as inhibitors of p38 mitogen-activated protein kinase (MAPK). The three-dimensional data obtained were used
Stefan Laufer +2 more
doaj +1 more source