Results 71 to 80 of about 9,296,901 (229)

Mass spectral studies of 3,5-Diamino-1,2,4-thiadiazoles

, 1977
The mass spectra and fragmentation mechanisms of some 5-alkyl(or aryl)amino-3-amino-, 5-amino-3- arylamino-, 3,5-bis(arylamino)-, 4- aryl-3-arylamino-5-imino-4,5-dihydro-, and 3-alkyl(or aryl)amino-4- aryl-5-arylimino-4,5-dihydro-1,2,4-thiadiazoles and ...
KN Rajasekharan, CP Joshua
core   +1 more source

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences, 2012
Two series of novel quinoline derivatives; oxadiazolyl and thiadiazolyl quinolines were prepared and evaluated for their antimicrobial activities. The first series; 5-(2-aryl-6-substituted-4-quinolyl)-1.3,4-oxadiazol-2-amines (Va-g) was synthesized by ...
Lobna Abdel-Aziz , Kamel Metwaly , El-Sayed Lashine , Rania Badawy   +3 more
doaj   +1 more source

2‐Pyrazoline‐5‐One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
2‐Pyrazoline‐5‐one derivative inhibits proliferation and migration and induces Bax‐mediated apoptosis in breast cancer cells. ABSTRACT The most common cancer in women worldwide is still breast cancer. Among its subtypes, luminal A and triple‐negative breast cancers present significant therapeutic challenges due to intrinsic drug resistance and absence ...
Sevgi Kocyigit Sevinc, Ş. Güniz Küçükgüzel, Sevim Rollas, Fulya Yukcu   +3 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles

Molecules, 2002
3-(2-Furanyl)-4-amino-5-mercapto-1,2,4-triazole (1) was prepared from 2-furoic acid through a multi-step reaction sequence. Compound 1 reacted with aromatic acids in the presence of phosphorus oxychloride to give 3-(2-furanyl)-6-aryl-1,2,4-triazolo[3,4-b]
Zi-Yi Zhang, Dong-Yong Chen, Xiang-Yun Nan, Xin-Xiang Lei, Xian-Xing Chen, An-Jiang Zhang, Li-Xue Zhang   +6 more
doaj   +1 more source

Design Principles for Next Generation of Small Organic Molecules for Photodynamics Therapy Revealed by Nonadiabatic Molecular Dynamics

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
Molecular design reshapes the landscape of excited‐state relaxation. Nonadiabatic dynamics reveal how electronic structure guides population flow between competing pathways beyond static energetic arguments. ABSTRACT Nitrobenzochalcogenadiazole derivatives are emerging candidates for photodynamic therapy (PDT), yet the precise mechanisms governing ...
Vinícius N. da Rocha, Davide Avagliano, Paulo C. Piquini   +2 more
wiley   +1 more source

Synthesis of γ‑Thiapyrones by Diels–Alder/Retro-Diels–Alder Reaction of α‑Pyrones with 5‑H‑1,2,3-Thiadiazoles

The efficient synthesis of γ-thiapyrones by a base-mediated Diels–Alder/retro-Diels–Alder reaction of α-pyrones with 5-H-1,2,3-thiadiazoles is reported herein.
Bin Huang (331329), Liangbin Huang (1687894), Mengxia Feng (18269197), Huanfeng Jiang (1392913)   +3 more
core   +1 more source

Electrochemical Synthesis of 1,2,3-Thiadiazoles from Phenylhydrazones

, 2021
We have developed an electrochemical approach for the synthesis of fully substituted 1,2,3-thiadiazoles from α-phenylhydrazones at room temperature, which is very challenging and complementary to the conventional thermal reactions.
Pragya Pali (9143670), Priya Saha, Priya Saha (10750110), Maya Shankar Singh, Gaurav Shukla, Maya Shankar Singh (1725268), Pragya Pali, Keshav Raghuvanshi, Keshav Raghuvanshi (1939177), Gaurav Shukla (2105080)   +9 more
core   +1 more source

Iodine‐Mediated Electrochemical Diastereoselective Synthesis of Enaminones

ChemElectroChem, Volume 13, Issue 12, 17 June 2026.
This work describes an efficient electrochemical (EC) method for transforming thioamides into enaminones via reaction with organic diazo compounds. The electrochemical approach is cost‐effective, mild, and proceeds through the in situ electrochemical generation of a copper complex.
Ijaz Khan, Głowacki Michał P., Rybicka‐Jasińska Katarzyna   +2 more
wiley   +1 more source

In vıtro Antioxidant Properties of Novel Compound (1R, 2R) -1,2-bis- (5- (4- Hydroxynaphthalen-1-ylazo) - [1,3,4] Thiadiazol-2-YL) -Ethane- 1,2-Diole

Cumhuriyet Science Journal, 2018
1,3,4-Thiadiazoles have a variety of biologicalactivities depending on their substituents. This study aims to investigatethe in vitro antioxidant properties of 1R,2R-1,2-bis- (5- (4-hydroxynaphthalen-1-ylazo) - [1,3,4] thiadiazol-2-yl) -ethane- 1,2-diole
Akif Evren Parlak, Pelin Koparır
doaj   +1 more source