Results 51 to 60 of about 3,896 (275)

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

Journal of Heterocyclic Chemistry, EarlyView.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad, Chithaluri Sudhakar, Vijaya Krishna Ravi, Bijaya Kethan Sahoo   +3 more
wiley   +1 more source

Sunlight Bleaching of Subporphyrazine Dye Films

Applied Sciences, 2023
Stable subphthalocyanine-type dyes with a high electron affinity attract much attention as potential substitutes for traditional fullerenes in molecular electronics devices.
Vlad V. Travkin, Danila A. Semikov, Pavel A. Stuzhin, Ivan A. Skvortsov, Georgy L. Pakhomov   +4 more
doaj   +1 more source

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF ANTICANCER ACTIVITY OF SOME NEW SCHIFF BASES OF 1, 3, 4-THIADIAZOLE DERIVATIVES [PDF]

, 2015
Objective: N-benzylidene-5-phenyl-1, 3, 4-thiadiazol-2-amine derivatives: Synthesis and anticancer activity.Methods: In the present study five new derivatives of N-benzylidene-5-phenyl-1, 3, 4-thiadiazol-2-amine (Schiff bases containing 1, 3, 4 ...
B, Ashok Kumar, Guria, Tanmoy, Maity, Tapan Kumar, Naskar, Arup, Singh, Jagadish, Singha, Tanushree   +5 more
core  

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety

Chemistry Central Journal, 2017
Background Pyrazolo[1,5-a]pyrimidines are purine analogues. They have beneficial properties as antimetabolites in purine biochemical reactions. This division compounds have attracted wide pharmaceutical interest because of their antitrypanosomal activity.
Nadia A. Abdelriheem, Yasser H. Zaki, Abdou O. Abdelhamid   +2 more
doaj   +1 more source

Fluorescent Supramolecular Gels Based on D‐Sorbitol Derivatives

Small, EarlyView.
Sugar‐based fluorescent low‐molecular‐weight gelators (LMWGs) DNapS, DBTDS, and MCumS, prepared by a green, scalable route, form supramolecular gels in water, organic, and deep eutectic solvents. MCumS yields solvent‐dependent nanofibrous networks and viscoelastic injectable eutectogels.
Emmanuel Odella, Miryam Criado‐Gonzalez, Rodrigo A. Ponzio, David Mecerreyes, Matías L. Picchio, Daniele Mantione   +5 more
wiley   +1 more source

DESIGN, SYNTHESIS AND ANTIFUNGAL EVALUATION OF NOVEL SUBSTITUTED 1, 3, 4-OXADIAZOLES, AND 1, 3, 4-THIADIAZOLES [PDF]

, 2015
Objective: The purpose of this research is to evaluate the antifungal activity of synthesized conjugates of thiophene with 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles using in vitro methods.Methods: The series of (IVa-e) and (Va-e) compounds were ...
Mishra, Pradeep, Upadhyay, Prabhat K
core  

Rational Design and Development of Organic Afterglow Nanoparticles for Image‐Guided Interventions

Small Methods, EarlyView.
This review outlines the rational design, synthesis, and standardized characterization of organic afterglow nanoparticles for biomedical imaging and therapy. Mechanistic insights into chemically initiated electron exchange luminescence and reactive oxygen species‐mediated processes are connected to molecular engineering and nanoparticle fabrication ...
Asma Harun, Isabella Vasquez, Hannah Bowman, Robert Posey, Zhongkui Hong, Joshua Tropp, Indrajit Srivastava   +6 more
wiley   +1 more source

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences, 2012
Two series of novel quinoline derivatives; oxadiazolyl and thiadiazolyl quinolines were prepared and evaluated for their antimicrobial activities. The first series; 5-(2-aryl-6-substituted-4-quinolyl)-1.3,4-oxadiazol-2-amines (Va-g) was synthesized by ...
Lobna Abdel-Aziz , Kamel Metwaly , El-Sayed Lashine , Rania Badawy   +3 more
doaj   +1 more source

Reaction strategies for synthesis of imidazole derivatives: a review [PDF]

, 2018
The development of a methodical directional synthesis of complex organic molecules with the aim of obtaining the physiologically active substance with selective action takes a central position in modern synthetic organic chemistry.
Atanasova-Stamova, Sylvia Yordanova, Georgieva, Maya Boyanova, Georgieva, Svetlana Fotkova   +2 more
core   +2 more sources