Results 11 to 20 of about 117,075 (151)

Structural and Biochemical Characterization of BdsA from Bacillus subtilis WU-S2B, a Key Enzyme in the “4S” Desulfurization Pathway [PDF]

Frontiers in Microbiology, 2018
Dibenzothiophene (DBT) and their derivatives, accounting for the major part of the sulfur components in crude oil, make one of the most significant pollution sources.
Tiantian Su, Jing Su, Jing Su, Shiheng Liu, Conggang Zhang, Jing He, Yan Huang, Sujuan Xu, Lichuan Gu   +8 more
doaj   +3 more sources

A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway

Frontiers in Microbiology, 2023
The recent discovery of the archaeal modified mevalonate pathway revealed that the fundamental units for isoprenoid biosynthesis (isopentenyl diphosphate and dimethylallyl diphosphate) are biosynthesized via a specific intermediate, trans ...
Mutsumi Komeyama, Kohsuke Kanno, Hiroyuki Mino, Yoko Yasuno, Tetsuro Shinada, Tomokazu Ito, Hisashi Hemmi   +6 more
doaj   +3 more sources

The Study of Biodesulfurization Activity in Recombinant E. coli Strain by Cloning the dsz Genes Involve in 4S Pathway [PDF]

Journal of Sciences, Islamic Republic of Iran, 2011
Several research groups have attempted to make recombinant bacteria capable of efficient desulfurization of oil fraction. The main aim of this study was to design a recombinant strain in order to desulfurize dibenzothiophen (DBT) and its components found
Jamshid Raheb
doaj   +2 more sources

Realigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies. [PDF]

Lancet Diabetes Endocrinol
Treating older people with diabetes is challenging due to multiple medical comorbidities that might interfere with patients' ability to perform self-care. Most diabetes guidelines focus on improving glycaemia through addition of medications, but few address strategies to reduce medication burden for older adults-a concept known as deprescribing ...
Munshi M, Kahkoska AR, Neumiller JJ, Alexopoulos AS, Allen NA, Cukierman-Yaffe T, Huang ES, Lee SJ, Lipska KJ, McCarthy LM, Meneilly GS, Pandya N, Pratley RE, Rodriguez-Mañas L, Sinclair AJ, Sy SL, Toschi E, Weinstock RS.   +17 more
europepmc   +3 more sources

4S‐AF scheme and ABC pathway guided management improves outcomes in atrial fibrillation patients [PDF]

European Journal of Clinical Investigation, 2022
AbstractBackgroundThe 4S‐AF scheme and the ABC pathway for integrated care have been proposed to better characterize and treat patients with atrial fibrillation (AF). We aimed to evaluate the assessment of the 4S‐AF scheme and ABC pathway in Chinese AF patients.MethodsThe ChiOTEAF is a prospective, observational, multicentre registry.
Guo, Yutao, Imberti, Jacopo F, Kotalczyk, Agnieszka, Wang, Yutang, Lip, Gregory Y H   +4 more
openaire   +3 more sources

Structural Plasticity of NFU1 Upon Interaction with Binding Partners: Insights into the Mitochondrial [4Fe-4S] Cluster Pathway

Journal of Molecular Biology, 2023
Published by Elsevier, Amsterdam [u.a.]
Da Vela, Stefano, Saudino, Giovanni, Lucarelli, Francesca, Banci, Lucia, Svergun, Dmitri I., Ciofi-Baffoni, Simone   +5 more
openaire   +4 more sources

Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase

Biochemistry, 2022
DNA synthesis during replication begins with the generation of an ∼10-nucleotide primer by DNA primase. Primase contains a redox-active 4Fe-4S cluster in the C-terminal domain of the p58 subunit (p58C). The redox state of this 4Fe-4S cluster can be modulated via the transport of charge through the protein and the DNA substrate (redox switching ...
Lauren E. Salay, Alexandra M. Blee, Md Kausar Raza, Kaitlyn S. Gallagher, Huiqing Chen, Andrew J. Dorfeuille, Jacqueline K. Barton, Walter J. Chazin   +7 more
openaire   +3 more sources

Inhibition of IspH, a [4Fe–4S]²⁺ Enzyme Involved in the Biosynthesis of Isoprenoids via the Methylerythritol Phosphate Pathway [PDF]

Journal of the American Chemical Society, 2013
The MEP pathway, which is absent in animals but present in most pathogenic bacteria, in the parasite responsible for malaria and in plant plastids, is a target for the development of antimicrobial drugs. IspH, an oxygen-sensitive [4Fe-4S] enzyme, catalyzes the last step of this pathway and converts (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMBPP)
Karnjapan, Janthawornpong, Sergiy, Krasutsky, Philippe, Chaignon, Michel, Rohmer, C Dale, Poulter, Myriam, Seemann   +5 more
openaire   +2 more sources

Diesel-born organosulfur compounds stimulate community re-structuring in a diesel-biodesulfurizing consortium

Biotechnology Reports, 2020
We enriched and characterized a biodesulfurizing consortium (designated as MG1). The MG1 consortium reduced the total sulfur of diesel by 25 % and utilized each of the diesel-born compounds dibenzothiophene (DBT), benzothiophene (BT), 4 ...
Maysoon Awadh, Huda Mahmoud, Raeid M.M. Abed, Ashraf M. El Nayal, Nasser Abotalib, Wael Ismail   +5 more
doaj   +1 more source

A pathway for assembling [4Fe‐4S]²⁺ clusters in mitochondrial iron–sulfur protein biogenesis

The FEBS Journal, 2019
During its late steps, the mitochondrial iron–sulfur cluster (ISC) assembly machinery leads to the formation of [4Fe‐4S] clusters. In vivo studies revealed that several proteins are implicated in the biosynthesis and trafficking of [4Fe‐4S] clusters in mitochondria. However, they do not provide a clear picture into how these proteins cooperate.
Nasta V, Suraci D, Gourdoupis S, Ciofi-Baffoni S, Banci L   +4 more
openaire   +3 more sources