Results 21 to 30 of about 155,151 (257)

Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase

Biochemistry, 2022
DNA synthesis during replication begins with the generation of an ∼10-nucleotide primer by DNA primase. Primase contains a redox-active 4Fe-4S cluster in the C-terminal domain of the p58 subunit (p58C). The redox state of this 4Fe-4S cluster can be modulated via the transport of charge through the protein and the DNA substrate (redox switching ...
Lauren E. Salay, Alexandra M. Blee, Md Kausar Raza, Kaitlyn S. Gallagher, Huiqing Chen, Andrew J. Dorfeuille, Jacqueline K. Barton, Walter J. Chazin   +7 more
openaire   +3 more sources

Structural Plasticity of NFU1 Upon Interaction with Binding Partners: Insights into the Mitochondrial [4Fe-4S] Cluster Pathway

Journal of Molecular Biology, 2023
Published by Elsevier, Amsterdam [u.a.]
Da Vela, Stefano, Saudino, Giovanni, Lucarelli, Francesca, Banci, Lucia, Svergun, Dmitri I., Ciofi-Baffoni, Simone   +5 more
openaire   +4 more sources

The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives

Molecules, 2022
The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms belonging to the Apicomplexa phylum, such as the parasite responsible for malaria.
Hannah Jobelius, Gabriella Ines Bianchino, Franck Borel, Philippe Chaignon, Myriam Seemann   +4 more
doaj   +1 more source

The Over-Expression of E2F3 Might Serve as Prognostic Marker for Neuroblastoma Patients with Stage 4S Disease

Diagnostics, 2020
Stage 4S neuroblastoma is a childhood cancer occurring in infants (
Stefano Parodi, Marzia Ognibene, Riccardo Haupt, Annalisa Pezzolo   +3 more
doaj   +1 more source

Bacterial Biological Factories Intended for the Desulfurization of Petroleum Products in Refineries

Fermentation, 2023
The removal of sulfur by deep hydrodesulfurization is expensive and environmentally unfriendly. Additionally, sulfur is not separated completely from heterocyclic poly-aromatic compounds. In nature, several microorganisms (Rhodococcus erythropolis IGTS8,
Abrar Ahmad, Mazin A. Zamzami, Varish Ahmad, Salwa Al-Thawadi, Mohammad Salman Akhtar, Mohd Jahir Khan   +5 more
doaj   +1 more source

Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis.

PLoS Pathogens, 2023
Mitochondrial metabolism is entirely dependent on the biosynthesis of the [4Fe-4S] clusters, which are part of the subunits of the respiratory chain.
Alžběta Motyčková, Luboš Voleman, Vladimíra Najdrová, Lenka Arbonová, Martin Benda, Vít Dohnálek, Natalia Janowicz, Ronald Malych, Róbert Šuťák, Thijs J G Ettema, Staffan Svärd, Courtney W Stairs, Pavel Doležal   +12 more
doaj   +1 more source

Inhibition of IspH, a [4Fe–4S]²⁺ Enzyme Involved in the Biosynthesis of Isoprenoids via the Methylerythritol Phosphate Pathway [PDF]

Journal of the American Chemical Society, 2013
The MEP pathway, which is absent in animals but present in most pathogenic bacteria, in the parasite responsible for malaria and in plant plastids, is a target for the development of antimicrobial drugs. IspH, an oxygen-sensitive [4Fe-4S] enzyme, catalyzes the last step of this pathway and converts (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMBPP)
Karnjapan, Janthawornpong, Sergiy, Krasutsky, Philippe, Chaignon, Michel, Rohmer, C Dale, Poulter, Myriam, Seemann   +5 more
openaire   +2 more sources

Aconitase causes iron toxicity in Drosophila pink1 mutants. [PDF]

PLoS Genetics, 2013
The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD ...
Giovanni Esposito, Melissa Vos, Sven Vilain, Jef Swerts, Jorge De Sousa Valadas, Stefanie Van Meensel, Onno Schaap, Patrik Verstreken   +7 more
doaj   +1 more source

Discovery and characterization of BlsE, a radical S-adenosyl-L-methionine decarboxylase involved in the blasticidin S biosynthetic pathway. [PDF]

PLoS ONE, 2013
BlsE, a predicted radical S-adenosyl-L-methionine (SAM) protein, was anaerobically purified and reconstituted in vitro to study its function in the blasticidin S biosynthetic pathway.
Jun Feng, Jun Wu, Nan Dai, Shuangjun Lin, H Howard Xu, Zixin Deng, Xinyi He   +6 more
doaj   +1 more source

Assembly and Transfer of Iron–Sulfur Clusters in the Plastid

Frontiers in Plant Science, 2018
Iron-Sulfur (Fe-S) clusters and proteins are essential to many growth and developmental processes. In plants, they exist in the plastids, mitochondria, cytosol, and nucleus.
Yan Lu
doaj   +1 more source