Results 41 to 50 of about 134,477 (121)

Analysis of cis-acting expression determinants of the tobacco psbA 5’UTR in vivo [PDF]

, 2002
Chloroplast gene expression is predominantly regulated at the posttranscriptional levels of mRNA stability and translation efficiency. The expression of psbA, an important photosynthesis-related chloroplast gene, has been revealed to be regulated via its
Zou, Zhurong
core  

Removal of 5 '- and 3 '-untranslated regions enhances erythropoietin gene expression in mammalian cells

, 2001
The effect of the 5′-and 3′-untranslated regions (UTR) of human erythropoietin gene (gEpo) on its expression in mammalian cells was investigated. 5′-UTR-deleted, 3′-UTR-deleted, and 5′,3′-UTR-deleted gEpos were transfected into COS-7 cells, and the ...
W B Kim, Young Kook Kim, J M Yang, J H Park, C Kim, S Y Lee   +5 more
core   +1 more source

RiboPlotR: a visualization tool for periodic Ribo-seq reads

Plant Methods, 2021
Background Ribo-seq has revolutionized the study of genome-wide mRNA translation. High-quality Ribo-seq data display strong 3-nucleotide (nt) periodicity, which corresponds to translating ribosomes deciphering three nts at a time.
Hsin-Yen Larry Wu, Polly Yingshan Hsu
doaj   +1 more source

HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions

, 1984
The rate-limiting enzyme of cholesterol biosynthesis, HMG CoA reductase, is controlled by negative feedback regulation of transcription. We have isolated the reductase gene from a bacteriophage λ genomic library prepared from hamster UT-1 cells.
Basu, Sandip K., Osborne, Timothy F., Goldstein, Joseph L., Luskey, Kenneth L., Reynolds, Gary A., Chin, Daniel J., Gil, Gregorio, Brown, Michael S.   +7 more
core   +1 more source

UTRdb and UTRsite : a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs [PDF]

, 2005
The 5' and 3' untranslated regions of eukaryotic mRNAs play crucial roles in the post-transcriptional regulation of gene expression through the modulation of nucleo-cytoplasmic mRNA transport, translation efficiency, subcellular localization and message ...
MIGNONE, Flavio, G. Grillo, J. Duarte, G. Pesole, F. Licciulli, C. Saccone, S. Liuni, P. J. Kersey, F. Mignone, M. Iacono   +9 more
core   +1 more source

Discovery of regulatory motifs in 5′ untranslated regions using interpretable multi-task learning models

, 2023
The sequence in the 5′ untranslated regions (UTRs) is known to affect mRNA translation rates. However, the underlying regulatory grammar remains elusive.
Ho, Joshua W K, Chu, Athena H Y, Huang, Yuanhua, Wan, Yuk Kei, Zheng, Weizhong, Fong, John H C, Wong, Alan S L   +6 more
core   +1 more source

Characterization and evolution of 5′ and 3′ untranslated regions in eukaryotes

, 2012
Untranslated regions (UTRs) in eukaryotes play a significant role in the regulation of translation and mRNA half-life, as well as interacting with specific RNA-binding proteins.
Mason, Annaliese S., Gao, Caihua, Fu, Donghui, Liu, Honglei, Liu, Yingchun, Zhao, Zunkang, Li, Jiana, Xiao, Meili, Yin, Jiaming   +8 more
core   +1 more source

Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1.

PLoS ONE, 2014
Eukaryotic cells control their growth and morphogenesis to maintain integrity and viability. Free-living cells are further challenged by their direct interaction with the environment and in many cases maintain a resilient cell wall to stay alive under ...
Antony G Wanless, Yuan Lin, Eric L Weiss
doaj   +1 more source

Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Nature Communications, 2020
Upstream open reading frames (uORFs), located in 5’ untranslated regions, are regulators of downstream protein translation. Here, Whiffin et al. use the genomes of 15,708 individuals in the Genome Aggregation Database (gnomAD) to systematically assess ...
Nicola Whiffin, Konrad J. Karczewski, Xiaolei Zhang, Sonia Chothani, Miriam J. Smith, D. Gareth Evans, Angharad M. Roberts, Nicholas M. Quaife, Sebastian Schafer, Owen Rackham, Jessica Alföldi, Anne H. O’Donnell-Luria, Laurent C. Francioli, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Stuart A. Cook, Paul J. R. Barton, Daniel G. MacArthur, James S. Ware   +18 more
doaj   +1 more source

Intragenomic rearrangements involving 5′-untranslated region segments in SARS-CoV-2, other betacoronaviruses, and alphacoronaviruses

Virology Journal, 2023
Background Variation of the betacoronavirus SARS-CoV-2 has been the bane of COVID-19 control. Documented variation includes point mutations, deletions, insertions, and recombination among closely or distantly related coronaviruses.
Roberto Patarca, William A. Haseltine
doaj   +1 more source