Results 11 to 20 of about 200 (107)

The influence of cdG on 8-oxodG excision by OGG1 and FPG glycosylases.

Acta Biochimica Polonica, 2022
Human genome is exposed to the variety of damaging factors, such as ionizing radiation. 5',8-cyclo-2'-deoxypurines (cdPus) are well described unfavorable outcomes of DNA damage, especially devastating as a part of clustered DNA lesions (CDL). Since cdPus
Michał Szewczuk, B. Karwowski
semanticscholar   +3 more sources

Structures of (5′S)-8,5′-Cyclo-2′-deoxyguanosine Mismatched with dA or dT [PDF]

Chemical Research in Toxicology, 2012
Diastereomeric 8,5′-cyclopurine 2′-deoxynucleosides, containing a covalent bond between the deoxyribose and the purine base, are induced in DNA by ionizing radiation.
Hai Huang, Rajat S Das, A. Basu, M. Stone   +3 more
semanticscholar   +4 more sources

Structural basis for the recognition of diastereomeric 5',8-cyclo-2'-deoxypurine lesions by the human nucleotide excision repair system. [PDF]

Nucleic Acids Res, 2014
The hydroxyl radical is a powerful oxidant that generates DNA lesions including the stereoisomeric R and S 5′,8-cyclo-2′-deoxyadenosine (cdA) and 5′,8-cyclo-2′-deoxyguanosine (cdG) pairs that have been detected in cellular DNA.
Kropachev K, Ding S, Terzidis MA, Masi A, Liu Z, Cai Y, Kolbanovskiy M, Chatgilialoglu C, Broyde S, Geacintov NE, Shafirovich V.   +10 more
europepmc   +2 more sources

Membrane Lipidome Reorganization and Accumulation of Tissue DNA Lesions in Tumor-Bearing Mice: An Exploratory Study. [PDF]

Cancers (Basel), 2019
Increased rates of reactive oxygen/nitrogen species (ROS/RNS) are involved in almost all cancer types, associated with tumor development and progression, causing damage to biomolecules such as proteins, nucleic acids and membrane lipids, in different ...
Krokidis MG, Louka M, Efthimiadou EK, Zervou SK, Papadopoulos K, Hiskia A, Ferreri C, Chatgilialoglu C.   +7 more
europepmc   +2 more sources

Detection of Oxidation Products of 5-Methyl-2′-Deoxycytidine in Arabidopsis DNA [PDF]

PLoS ONE, 2013
Epigenetic regulations play important roles in plant development and adaptation to environmental stress. Recent studies from mammalian systems have demonstrated the involvement of ten-eleven translocation (Tet) family of dioxygenases in the generation of
Shuo Liu, Thomas L. Dunwell, G. Pfeifer, J. Dunwell, I. Ullah, Yinsheng Wang   +5 more
semanticscholar   +3 more sources

Mutagenicity and genotoxicity of (5'S)-8,5'-cyclo-2'-deoxyadenosine in Escherichia coli and replication of (5'S)-8,5'-cyclopurine-2'-deoxynucleosides in vitro by DNA polymerase IV, exo-free Klenow fragment, and Dpo4. [PDF]

Chem Res Toxicol, 2014
Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5′-cyclo-2′-deoxyadenosine (cdA) and 8,5′-cyclo-2′-deoxyguanosine (cdG).
Pednekar V, Weerasooriya S, Jasti VP, Basu AK.   +3 more
europepmc   +2 more sources

New Insights into the Reaction Paths of Hydroxyl Radicals with Purine Moieties in DNA and Double-Stranded Oligodeoxynucleotides. [PDF]

Molecules, 2019
The reaction of hydroxyl radical (HO•) with DNA produces many primary reactive species and many lesions as final products. In this study, we have examined the optical spectra of intermediate species derived from the reaction of HO• with a variety of ...
Chatgilialoglu C, Krokidis MG, Masi A, Barata-Vallejo S, Ferreri C, Terzidis MA, Szreder T, Bobrowski K.   +7 more
europepmc   +3 more sources

Induction of 8,5'-cyclo-2'-deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents. [PDF]

Chem Res Toxicol, 2013
Guerrero CR, Wang J, Wang Y.
europepmc   +2 more sources

Stability of N-glycosidic bond of (5'S)-8,5'-cyclo-2'-deoxyguanosine. [PDF]

Chem Res Toxicol, 2012
Das RS, Samaraweera M, Morton M, Gascón JA, Basu AK.   +4 more
europepmc   +2 more sources

Synthesis of [1,3, NH2-(15)N3] (5'S)-8,5'-cyclo-2'-deoxyguanosine. [PDF]

J Labelled Comp Radiopharm, 2013
Malik CK, Das RS, Basu AK.
europepmc   +2 more sources