Results 31 to 40 of about 200 (107)
Radical-induced purine lesion formation is dependent on DNA helical topology
Free radical research, 2016 Herein we report the quantification of purine lesions arising from gamma-radiation sourced hydroxyl radicals (HO•) on tertiary dsDNA helical forms of supercoiled (SC), open circular (OC), and linear (L) conformation, along with single-stranded folded and
Michael A. Terzidis +8 more
semanticscholar +1 more source
Novel Antitumoral Strategies Inducing Membrane Lipid and DNA Damage:Artificial Chemical Nucleases & the ‘ClickGene’ Project [PDF]
, 2019 This PhD project was carried out within the frame of a Marie Curie Network with the acronym ‘ClickGene’, which focuses on the development of next-generation gene silencing therapeutics, such as the artificial metallo-nucleases (AMNs).
Menounou, Georgia <1991>
core +1 more source
Metabolic Network Analysis of Filamentous Cyanobacteria [PDF]
, 2020 Cyanobacteria were the first organisms to use oxygenic photosynthesis, converting CO2 into useful organic chemicals. However, the chemical industry has historically relied on fossil raw materials to produce organic precursors, which has contributed to ...
Norena-Caro, Daniel Alexis
core +2 more sources
Chemistry meets biology in colitis-associated carcinogenesis [PDF]
, 2013 The intestine comprises an exceptional venue for a dynamic and complex interplay of numerous chemical and biological processes. Here, multiple chemical and biological systems, including the intestinal tissue itself, its associated immune system, the gut ...
Dedon, Peter C. +4 more
core +1 more source
Biochemistry, 2011 8,5′-Cyclopurines, making up an important class of ionizing radiation-induced tandem DNA damage, are repaired only by nucleotide excision repair (NER).
Vijay P. Jasti +5 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 In this work, we used ωB97XD density functional and 6-31++G** basis set to study the structure, electron affinity, populations via Boltzmann distribution, and one-electron reduction potentials (E°) of 2′-deoxyribose sugar radicals in aqueous phase by ...
Michael Bell, Anilesh Kumar, M. Sevilla
semanticscholar +1 more source
Mutagenesis and Genetic Control of Translesion Synthesis Across an Abasic Site, 8,5’-Cyclopurines and \u3cem\u3eO\u3c/em\u3e\u3csup\u3e2\u3c/sup\u3e-Alkylthymidine DNA Lesions [PDF]
, 2015 DNA contains the genetic information of all living organisms. Therefore, its integrity and stability are essential for the long-term viability of the organism.
Weerasooriya, Savithri Anurada Kumari
core +1 more source
Molecules, 2020 Oxidatively generated damage to DNA frequently appears in the human genome as the effect of aerobic metabolism or as the result of exposure to exogenous oxidizing agents, such as ionization radiation.
B. Karwowski
semanticscholar +1 more source
Products of Oxidative Guanine Damage Form Base Pairs with Guanine
International Journal of Molecular Sciences, 2020 Among the natural bases, guanine is the most oxidizable base. The damage caused by oxidation of guanine, commonly referred to as oxidative guanine damage, results in the formation of several products, including 2,5-diamino-4H-imidazol-4-one (Iz), 2,2,4 ...
K. Kino +4 more
semanticscholar +1 more source
UEG Week 2014 Poster Presentations
, 2014 United European Gastroenterology Journal, Volume 2, Issue S1, Page A132-A605, October 2014.
wiley +1 more source