Results 11 to 20 of about 46,559 (243)

High Real-World Medication Adherence and Durable Clinical Benefit in Medicare Patients Treated with 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia [PDF]

Journal of Urology, 2020
Daniel M Frendl, Zongwei Wang, Aria F Olumi   +2 more
exaly   +2 more sources

Prostate Cancer Mortality and Use of 5-Alpha Reductase Inhibitors. [PDF]

World J Mens Health, 2020
Foldes CA, Wang R, Canfield SE.
europepmc   +5 more sources

Risk of estrogen-driven malignancies in females on 5-alpha reductase inhibitors

Archives of Dermatological Research
Abstract Importance: It is hypothesized that 5α-reductase inhibitors (5aRI) increase aromatase-mediated conversion of testosterone to estrogen, which may facilitate development of estrogen-driven malignancy. Previous studies in male patients receiving 5aRI treatment failed to demonstrate an increased risk of breast cancer; however, similar ...
Thomas Z Rohan, Sherry Yang
exaly   +3 more sources

The Use of 5-Alpha Reductase Inhibitors to Manage Benign Prostatic Hyperplasia and the Risk of All-cause Mortality [PDF]

Urology, 2018
Lauren P Wallner, Stephen K Van Den Eeden, Ralph I Horwitz   +2 more
exaly   +2 more sources

The connection of 5-alpha reductase inhibitors to the development of depression

Biomedicine & Pharmacotherapy, 2021
Recent literature connects 5-alpha reductase inhibitors (5-ARIs) with neuropsychiatric adverse effects. Several clinical studies have indicated that former 5-ARIs users had a higher incidence of depressive symptoms and neuropsychiatric side effects than non-users.
Thiraphat, Saengmearnuparp, Bannakij, Lojanapiwat, Nipon, Chattipakorn, Siriporn, Chattipakorn   +3 more
openaire   +2 more sources

Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]

, 2014
The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Kirsten Stewart, Michael P. Barrett, Pui Ee Wong, William N. Hunter, Barrack, Keri L., Hunter, William N., Huggan, Judith, Colin L. Gibson, Judith K. Huggan, Barrett, Michael P., Federica Giordani, Suckling, Colin J., Colin J. Suckling, Khalaf, Abedawn I., Huggan, Judith K., Wong, Pui Ee, Khalaf, Abedawn I, Barrack, Keri L, Stewart, Kirsten, Keri L. Barrack, Suckling, Colin J, Hunter, Wililam N., Gibson, Colin L., Giordani, Federica, Gibson, Colin L, Abedawn I. Khalaf, Hunter, William N   +26 more
core   +1 more source

5-Alpha Reductase Inhibitors and the Risk of Prostate Cancer Mortality in Men Treated for Benign Prostatic Hyperplasia [PDF]

Mayo Clinic Proceedings, 2016
Lauren P Wallner, Stephen K Van Den Eeden, Kathryn Richert-Boe   +2 more
exaly   +2 more sources

5 alpha-Reductase Inhibitors and Risk of Prostate Cancer Death

, 2020
Purpose: 5 alpha-Reductase inhibitors reduced the risk of prostate cancer in 25% in 2 randomized trials but increased the risk of Gleason 8-10 at biopsy. One explanation is that 5 alpha-reductase inhibitors induce morphological changes in prostate cancer
Robinson, David,, Stattin, Pär,, Garmo, Hans,, Miranda, Tiago Bonde,   +3 more
core   +1 more source

Outcomes of Prostate Cancer Screening by 5 alpha-Reductase Inhibitor Use [PDF]

, 2017
Purpose: Prostate cancer screening with prostate specific antigen reduces prostate cancer mortality but leads to over diagnosis of indolent prostate cancer.
Murtola, Teemu J., Kirsi Talala, Ulf-Håkan Stenman, Kimmo Taari, Taari, Kimmo, Virkku, Anniina, Teemu J. Murtola, Talala, Kirsi, Teuvo L.J. Tammela, Anssi Auvinen, Stenman, Ulf-Hakan, Tammela, Teuvo L. J., Auvinen, Anssi, Anniina Virkku   +13 more
core   +1 more source

SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. [PDF]

, 2010
N-linked glycosylation is the most frequent modification of secreted and membrane-bound proteins in eukaryotic cells, disruption of which is the basis of the congenital disorders of glycosylation (CDGs).
Hudson H. Freeze, Silhavy, J.L., Christian R.H. Raetz, Al-Gazali, Lihadh, Swistun, Dominika, Dusica Babovic-Vuksanovic, Guan, Z., Blümel, Peter, Sykut-Cegielska, J., Hans van Bokhoven, Bokhoven, J.H.L.M. van, Ludwig Lehle, Lehle, Ludwig, Wevers, R.A., Al-Gazali, L., Houliston, S., Dobyns, W.B., Bassam R. Ali, Lefeber, D.J., Ali, Bassam R., Raetz, Christian R.H., Dirk J. Lefeber, Guan, Ziqiang, Ron A. Wevers, Hans Hombauer, Maciej Adamowicz, Jolanta Sykut-Cegielska, Stephanie L. Bielas, Ng, B.G., Freeze, H.H., Ewa Swiezewska, Wevers, Ron A., William B. Dobyns, Gleeson, Joseph G., Bobby G. Ng, Cantagrel, Vincent, Ng, Bobby G., Swiezewska, Ewa, Lefeber, Dirk J., De Brouwer, Arjan P., Houliston, Scott, Adamowicz, M., Silhavy, Jennifer L., Lihadh Al-Gazali, Ziqiang Guan, Éva Morava, Dobyns, William B., Adamowicz, Maciej, Morava, E., Babovic-Vuksanovic, Dusica, Raetz, C.R., Vincent Cantagrel, Lehle, L., Hombauer, H., Scott Houliston, Freeze, Hudson H., Jennifer L. Silhavy, Swistun, D., Blumel, P., Babovic-Vuksanovic, D., Cantagrel, V., Gleeson, J.G., Peter Blümel, Sykut-Cegielska, Jolanta, Arjan P. De Brouwer, Morava, Éva, Joseph G. Gleeson, Brouwer, A.P.M. de, van Bokhoven, Hans, Swiezewska, E., Hombauer, Hans, Dominika Swistun, Bielas, S.L., Ali, B.R., Bielas, Stephanie L.   +74 more
core   +1 more source