Antipsychotic-Like Properties of 5-α-Reductase Inhibitors [PDF]
Neuropsychopharmacology, 2008 Recent evidence indicates that neuroactive steroids may participate in the pathogenesis of schizophrenia spectrum disorders, yet the mechanisms of this involvement are elusive. As 5-alpha-reductase (5AR) is the rate-limiting enzyme of one of the two major metabolic pathways in brain steroidogenesis, we investigated the effects of its blockade in ...
Bortolato M +7 more
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Ribonucleotide reductase in dividing cells: Purification and inhibition studies with 4-hydroxynonenal [PDF]
, 1992 This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.1). The effect of temperature, P450 inhibitors (pyrazole and imidazole), sulphydryl reagents (iodoacetamide and N-ethyl maleimide) and glutathione on ...
Li, Li
core +7 more sources
May patients receiving 5-alpha-reductase inhibitors be in higher risk of COVID-19 complications? [PDF]
Med Hypotheses, 2020 COVID-19 pandemic is a major challenge for global and national healthcare providers. Number of new cases is continuously increasing with an emerging trend showing worse prognosis in males in comparison to females.
Adamowicz J, Juszczak K, Drewa T.
europepmc +2 more sources
Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]
, 2014 The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Kirsten Stewart +26 more
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Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled "banana-shaped" shell. [PDF]
Sci Rep, 2019 In vertebrates, the steroidogenesis enzyme 5α-reductase converts testosterone to the more potent androgen 5α-dihydrotestosterone. Homologues of 5α-reductase genes have been identified in molluscs.
Baynes A +6 more
europepmc +2 more sources
5 alpha-Reductase Inhibitors and Risk of Prostate Cancer Death
, 2020 Purpose: 5 alpha-Reductase inhibitors reduced the risk of prostate cancer in 25% in 2 randomized trials but increased the risk of Gleason 8-10 at biopsy. One explanation is that 5 alpha-reductase inhibitors induce morphological changes in prostate cancer
Robinson, David, +3 more
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Human prostatic steroid 5 alpha-reductase isoforms--a comparative study of selective inhibitors
, 1995 The present study describes the independent expression of the type 1 and 2 isoforms of human 5 alpha-reductase in the baculovirus-directed insect cell expression system and the selectivity of their inhibition.
Guirou, Olivier +5 more
core +4 more sources
Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome [PDF]
Skin Appendage Disorders, 2016 Postfinasteride syndrome (PFS) is a term recently coined to characterize a constellation of reported undesirable side effects described in postmarketing reports and small uncontrolled studies that developed during or after stopping finasteride treatment, and persisted after drug discontinuation. Symptoms included decreased libido, erectile dysfunction,
Raymond Fertig +3 more
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, 2017 Background/Purpose: Large total prostate volumes (TPVs) or high serum prostate-specific antigen (PSA) levels indicate high-risk clinical progression of benign prostatic hyperplasia.
Lin, Victor C.;Liao, Chun-Hou;Wang, Chung-Cheng;Kuo, Hann-Chorng
core +1 more source
Outcomes of Prostate Cancer Screening by 5 alpha-Reductase Inhibitor Use [PDF]
, 2017 Purpose: Prostate cancer screening with prostate specific antigen reduces prostate cancer mortality but leads to over diagnosis of indolent prostate cancer.
Murtola, Teemu J. +13 more
core +1 more source