Results 41 to 50 of about 44,133 (142)

Symptomatic benign prostatic hyperplasia: the role of 5-alpha-reductase inhibitors in the prevention of acute urinary retention and surgical therapy

Italian Journal of Medicine, 2012
Benign prostatic hyperplasia (BPH) is a disease that affects over 50% of males aged 50 years or older. In men aged >80 years, the incidence is 90%. BPH occurs in 9-25% of males aged 40 to 79 years. Fifty percent of patients with BPH are symptomatic.
Norma Marigliano, Domenico Galasso
doaj   +1 more source

Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment

The World Journal of Men's Health, 2019
Purpose: The current study is aimed to assess whether a longer duration of 5α-reductase inhibitor (5α-RI) exposure was asso-ciated with higher rate of permanent erectile dysfunction (ED) in a rat model.
Hyun Hwan Sung, Jiwoong Yu, Su Jeong Kang, Mee Ree Chae, Insuk So, Jong Kwan Park, Sung Won Lee   +6 more
doaj   +1 more source

Update on the use of dutasteride in the management of benign prostatic hypertrophy

Clinical Interventions in Aging, 2007
Joe Miller, Thomas H TarterDivision of Urology, Southern Illinois University School of Medicine, Springfield, IL, USAAbstract: Benign prostatic hyperplasia (BPH) is a frequent cause of lower urinary symptoms, with a prevalence of 50% by the sixth decade ...
Joe Miller, Thomas H Tarter
doaj  

Combination therapy with dutasteride and tamsulosin for the treatment of symptomatic enlarged prostate

Clinical Interventions in Aging, 2009
J Miller, TH TarterSouthern Illinois University School of Medicine, Department of Surgery, Springfield, IL, USAAbstract: Benign prostatic hyperplasia (BPH) is a frequent cause of lower urinary symptoms, with a prevalence of 50% by the sixth decade of ...
J Miller, TH Tarter
doaj  

Dynamics of prostate protectors assortment in the state formulary of medicines of 1-9 issues

Фармацевтичний журнал, 2018
Prostatitis is one of the most frequent urology diseases of men of reproductive age. Recommendations for rational pharmacotherapy prostatitis are included into the State Formulary of Medicines, which is reviewed and updated annually. Thus, the aim of our
І. V. Gadyak, B. P. Hromovyk
doaj   +1 more source

Do statins decrease testosterone in men? Systematic review and meta-analysis

International Brazilian Journal of Urology
Purpose: Statins are one of the most prescribed classes of drugs worldwide to treat hypercholesterolemia and dyslipidemia. By lowering the level of cholesterol, the use of statin could cause a reduction in testosterone levels.
Felipe Placco Araujo Glina, Leonardo Lopes, Rodrigo Spinola e Silva, Eduardo Augusto Correa Barros, Bruno Biselli, Sidney Glina   +5 more
doaj   +1 more source

A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride

BMC Musculoskeletal Disorders, 2018
Background Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is unknown.
Tony Antoniou, Erin M. Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M.-W. Ho, Muhammad M. Mamdani, David N. Juurlink, for the Canadian Drug Safety and Effectiveness Research Network   +8 more
doaj   +1 more source

HPLC characterization, molecular docking, QSAR and molecular dynamics simulation of Alstonia boonei phytochemical analogs as potent 5-alpha reductase inhibitors

Discover Chemistry
Background Current chemotherapy for Benign Prostatic Hyperplasia (BPH) relies on 5-alpha reductase inhibitors like Finasteride and Dutasteride, which are associated with significant side effects.
Olumide Oluyele, Adedoyin John-Joy Owolade, Ayomide Precious Ajiboro, Victor Onoriode Unuaru, Temitope Ibukunoluwa Adegbenro, Adedapo Bolanle Esther, Bello Nafisat Oniboki, Oluwadetimi Oluwafunmilayo Ajayi, Chukwunenye Christopher Azubuike, Musiliyu Ayofe Salawu, Damilola Alex Omoboyowa, Damilola Samuel Bodun   +11 more
doaj   +1 more source

Hormonal manipulation of lower urinary tract symptoms secondary to benign prostatic obstruction

Indian Journal of Urology, 2014
Although the etiology of lower urinary tract symptoms (LUTS) is often multifactorial, a significant proportion of men over the age of 50 suffer from benign prostatic obstruction (BPO) secondary to benign prostatic hyperplasia. Prostate, being an androgen
Adita Raja, Satoshi Hori, James N Armitage   +2 more
doaj   +1 more source

Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-substituted 15-oxygenated sterols.

Journal of Lipid Research, 1979
Reported herein are the results of investigations of the effects of a number of 14 alpha-alkyl-substituted 15-oxygenated sterols, prepared by chemical synthesis, on sterol biosynthesis and the levels of 3-hydroxy-3-methylglutaryl CoA reductase activity ...
G J Schroepfer, Jr, E J Parish, M Tsuda, D L Raulston, A A Kandutsch   +4 more
doaj   +1 more source