Results 51 to 60 of about 96,820 (286)

Estudio de la expresión de receptores de andrógenos, estrógenos y progesterona mediante inmunohistoquímica en pacientes con alopecia frontal fibrosante

Revista Médica Clínica Las Condes, 2023
Resumen: Introducción: La alopecia frontal fibrosante (AFF) es una alopecia linfocítica primaria cicatricial, cuya patogenia se desconoce. Se han desarrollado distintos regímenes de tratamientos farmacológicos, siendo el finasteride por sí sólo o en ...
Néstor Carreño-Orellana, Daniela Alfaro-Sepúlveda, María Paz Traipe, Verónica Vial-Letelier   +3 more
doaj   +1 more source

Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates. [PDF]

, 2013
The efficient production of biofuels from cellulosic feedstocks will require the efficient fermentation of the sugars in hydrolyzed plant material.
Arkin, Adam P, Bauer, Stefan, Baumohl, Jason K, Deutschbauer, Adam M, Hazen, Terry, Hu, Ping, Ibáñez, Ana B, Leon, Dacia, Mar, Jordan S, Mitchell, Valerie D, Price, Morgan N, Skerker, Jeffrey M, Tarjan, Daniel R, Wetmore, Kelly M, Wu, Cindy H   +14 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

5-Alpha Reductase Inhibitors and the Risk of Prostate Cancer Mortality in Men Treated for Benign Prostatic Hyperplasia. [PDF]

Mayo Clin Proc, 2016
Wallner LP, DiBello JR, Li BH, Van Den Eeden SK, Weinmann S, Ritzwoller DP, Abell JE, D'Agostino R, Loo RK, Aaronson DS, Richert-Boe K, Horwitz RI, Jacobsen SJ.   +12 more
europepmc   +2 more sources

Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy [PDF]

, 2014
AIM: To study the contribution of tonicity response element binding protein (TonEBP) in retinal ganglion cell (RGC) death of diabetic retinopathy (DR). METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/
Choi, Wan-Sung, Chung, Inyoung, Kim, Hwajin, Kim, Seong-Jae, Kwon, H. Moo, Park, Jeongsook, Yoo, Ji-Myong   +6 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Five-alpha Reductase Inhibitor Influences Expression of Androgen Receptor and HOXB13 in Human Hyperplastic Prostate Tissue

International Brazilian Journal of Urology, 2013
Objectives Five-alpha reductase inhibitors (5ARIs) are known as chemopreventive agents in prostate cancer with a risk of high-grade disease. This study evaluated the effects of 5ARI on androgen receptor (AR) and proteins involved in prostate cell growth ...
Chaeyong Jung, Youngwoong Park, Young-Rang Kim, Soo Bang Ryu, Taek Won Kang   +4 more
doaj   +1 more source

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. [PDF]

, 2016
Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity.
Bakirtzi, K, Cheng, M, Fisseha, E, Fleshner, P, Gallo, RL, Hing, TC, Ho, S, Hoang-Ngoc Tran, D, Hoang-Yen Tran, D, Karagiannides, I, Koon, HW, Law, I, Lee, EC, Lee, JE, Li, Z, Mattai, SA, McGovern, DPB, Ortiz, C, Robbins, L, Sallam, T, Shieh, C, Shih, DQ, Sideri, A, Su, B, Targan, SR, Vu, M   +25 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Symptomatic benign prostatic hyperplasia: the role of 5-alpha-reductase inhibitors in the prevention of acute urinary retention and surgical therapy

Italian Journal of Medicine, 2012
Benign prostatic hyperplasia (BPH) is a disease that affects over 50% of males aged 50 years or older. In men aged >80 years, the incidence is 90%. BPH occurs in 9-25% of males aged 40 to 79 years. Fifty percent of patients with BPH are symptomatic.
Norma Marigliano, Domenico Galasso
doaj   +1 more source