Results 21 to 30 of about 46,559 (243)
Management of benign prostate hyperplasia (BPH) by combinatorial approach using alpha-1-adrenergic antagonists and 5-alpha-reductase inhibitors. [PDF]
, 2020 Currently, the main available treatments for benign prostate hyperplasia (BPH) are alpha-1 adrenergic receptor antagonists (ARAs), 5-alpha reductase inhibitors (5-αRI), anticholinergics, and Phosphodiesterase-5 inhibitors.
Mohammad R. Hamad +5 more
core +1 more source
5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection
The Journal of Sexual Medicine, 2008 ABSTRACT Introduction Benign prostatic hyperplasia (BPH) is a common problem affecting middle-aged and elderly men. First-line medical therapy includes α 1blockers and 5α-reductase inhibitors (5ARIs), such as finasteride and dutasteride.
Fikret, Erdemir +2 more
openaire +2 more sources
, 2020 This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effects of 5-alpha-reductase inhibitors (5ARIs) for treating lower urinary tract symptoms (LUTS) secondary to benign prostatic obstruction (BPO ...
Tacklind, James +2 more
core +1 more source
, 2015 The 5-year Cumulative incidence of cardiovascular diseases in those receiving and not receiving 5-alpha reductase inhibitors.
Tien-Huang Lin (631773) +8 more
core +1 more source
Effects of 5-alpha reductase inhibitors
Current Opinion in Urology, 2018 The use of 5-alpha reductase inhibitors (5ARIs) for the treatment of benign prostatic hyperplasia (BPH) and other diseases has been proposed and studied. However, the controversy about its benefits and harms for other diseases has persisted. In this review, we will discuss the newly identified effects of 5ARIs based on recently published studies.These ...
Joo Yong, Lee, Kang Su, Cho
openaire +3 more sources
, 2015 SD, Standard deviation. ANGII, Angiotensin II Inhibitors. CCI, Charlson weighted comorbidity index. TURP, Transurethral resection of prostateBaseline characteristics for men exposed to 5 alpha reductase inhibitors (5-ARI) and selected non exposed men.
David Robinson (73947) +3 more
core +1 more source
Human prostatic steroid 5 alpha-reductase isoforms--a comparative study of selective inhibitors
, 1995 The present study describes the independent expression of the type 1 and 2 isoforms of human 5 alpha-reductase in the baculovirus-directed insect cell expression system and the selectivity of their inhibition.
Martin, P M +11 more
core +1 more source
Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]
, 1999 The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Erl, Wolfgang +7 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source