Results 1 to 10 of about 9,812 (151)

Systematic Review and Meta-Analysis of In Vitro Anti-Human Cancer Experiments Investigating the Use of 5-Aminolevulinic Acid (5-ALA) for Photodynamic Therapy [PDF]

Pharmaceuticals, 2021
5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT).
Yo Shinoda, Daitetsu Kato, Ryosuke Ando, Hikaru Endo, Tsutomu Takahashi, Yayoi Tsuneoka, Yasuyuki Fujiwara   +6 more
doaj   +4 more sources

Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA) [PDF]

Journal of Diabetes Research, 2019
5-Aminolevulinic acid (5-ALA) is a delta amino acid naturally present in every living cell of the human body. 5-ALA is produced in the mitochondria as the first product of the porphyrin synthesis pathway and composes heme; exogenously supplemented 5-ALA ...
Peter R. Rehani, Hanaa Iftikhar, Motowo Nakajima, Tohru Tanaka, Zaid Jabbar, Riyadh N. Rehani   +5 more
doaj   +6 more sources

HGG-19. 5-AMINOLEVULINIC ACID (5-ALA)-GUIDED RESECTION OF PEDIATRIC BRAIN TUMORS [PDF]

Neuro Oncol, 2021
Abstract Between tumor and normal brain, allowing a higher degree of resection, and improved patient outcomes. In recent years, several reports have emerged regarding the use of 5-ALA in other brain tumor entities, including pediatric brains tumors.
Schwake M, Bruns A, Müther M, Schipmann S, Stummer W.   +4 more
europepmc   +4 more sources

5-Aminolevulinic Acid (5-ALA)-Induced Protoporphyrin IX Fluorescence by Glioma Cells-A Fluorescence Microscopy Clinical Study. [PDF]

Cancers (Basel), 2022
5-aminolevulinic acid (5-ALA)-induced PpIX fluorescence is used by neurosurgeons to identify the tumor cells of high-grade gliomas during operation. However, the issue of whether 5-ALA-induced PpIX fluorescence consistently stains all the tumor cells is still debated.
Pacioni S, D'Alessandris QG, Giannetti S, Della Pepa GM, Offi M, Giordano M, Caccavella VM, Falchetti ML, Lauretti L, Pallini R.   +9 more
europepmc   +5 more sources

5-Aminolevulinic Acid (5-ALA) Use at The Walton Centre NHS Foundation Trust (WCFT) [PDF]

Neuro Oncol, 2022
Abstract AIMS To audit the use of 5-ALA at WCFT to determine adherence to NICE guidance [NG99] and the Trust guideline. METHOD Data was retrospectively evaluated from 77 patients prescribed 5-ALA at WCFT Jan 2020 – Jan 2022.
Ruth Bennett, Elizabeth Akinsanya
europepmc   +2 more sources

THE USE OF 5-AMINOLEVULINIC ACID (5-ALA) IN HIGH-GRADE GLIOMA SURGERY, A SINGLE CANADIAN CENTER EXPERIENCE [PDF]

Neurooncol Adv, 2023
Abstract 5-Aminolevulinic acid (5-ALA) is a prodrug used to selectively illuminate high-grade glioma (HGG) tissue intra-operatively, shown to nearly double complete resection rates in a 2006 multicentre, phase III clinical trial. Here, we review the history of the 2020 approval of 5-ALA in Canada and present some of the first preliminary
LeBlanc, Félix, Boone, Lyndon, Noble, Timothy, Burns, Jane, Fawaz, Charbel, Charest, Dhany, El Helou, Antonios   +6 more
europepmc   +3 more sources

5-Aminolevulinic Acid (5-ALA) Plays an Important Role in the Function of Innate Immune Cells. [PDF]

Inflammation
5-aminolevulinic acid (5-ALA) is an amino acid essential for the synthesis of heme, which is important for various cellular functions, including the mitochondrial electron transport chain. We previously established heterozygous knockout mice (Alas1+/-) for 5-ALA synthase 1 (ALAS1), the rate-limiting enzyme for 5-ALA synthesis, and reported that the ...
Saitoh S, Takeda Y, Araki A, Nouchi Y, Yamaguchi R, Nakajima O, Asao H.   +6 more
europepmc   +3 more sources

Molecular Characteristics of High-Grade Glioma in Relation to 5-Aminolevulinic Acid (5-ALA) Fluorescence Intensity. [PDF]

Cureus
5-aminolevulinic acid (5-ALA) fluorescence used in glioma surgery has different intensities within tumors and among different patients, some molecular and external factors have been implicated, but there is no clear evidence analyzing the difference of fluorescence according to glioma molecular characteristics.
Garfias-Arjona S, Lara-Almunia M, Antón-Valentí E, Pierola-Lopetegui J, Bestard-Escalas J, Maimó-Barceló A, Marzese-Parrilli DM, Íñiguez-Muñoz S, Ensenyat-Mendez M, Brell M.   +9 more
europepmc   +4 more sources

Photodynamics of Subependymal Giant Cell Astrocytoma (SEGA) with 5-Aminolevulinic Acid (5-ALA/Gliolan©) [PDF]

Neuro Oncol, 2022
Abstract AIMS 5-ALA (Gliolan©) is a valuable surgical tool used predominantly in high grade tumours, which utilises tissue fluorescence to improve the visualisation of the brain-tumour interface. This ensures safe maximal resection, while preserving healthy brain.
Imran Ghani, Sabina Patel, Istvan Bodi, Francesco Vergani, Keyoumars Ashkan, Ranjeev Bhangoo, Jose Pedro Lavrador   +6 more
europepmc   +2 more sources

5-Aminolevulinic Acid (5-ALA)-Induced Drought Resistance in Maize Seedling Root at Physiological and Transcriptomic Levels. [PDF]

Int J Mol Sci
Drought stress seriously affects the growth, development, yield, and quality of maize. This study aimed to investigate the effects of exogenous 5-ALA on root morphology and physiological changes in maize seedlings and to detect its regulatory network.
Shi Y, Jin Z, Wang J, Zhou G, Wang F, Peng Y.   +5 more
europepmc   +3 more sources