Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases. [PDF]
MedComm (2020)Salivary metabolomics offers a noninvasive and effective approach for early disease detection and monitoring. Salivary metabolites reflect systemic metabolism, inflammation, and external factors such as diet and stress. Advance in bioinformatics and machine learning facilitates the identification of metabolic biomarkers with high diagnostic accuracy ...
Zhao X +8 more
europepmc +2 more sources
Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy. [PDF]
PLoS ONE, 2013 Photodynamic therapy (PDT) is a safe and effective method currently used in the treatment of skin cancer. In ALA-based PDT, 5-aminolevulinic acid (ALA), or ALA esters, are used as pro-drugs to induce the formation of the potent photosensitizer ...
Yan Baglo +3 more
doaj +1 more source
The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acid [PDF]
Journal of Photochemistry and Photobiology B: Biology, 2006 The influence of skin permeation enhancers, such as dimethyl sulphoxide (DMSO) and 1-[2-(decylthio)ethyl]azacyclopentan-2-one (HPE-101), Labrafac CC, Labrafil, Labrasol and Transcutol in a concentration of 10% (wt./wt.) on the formation of porphyrins in normal mouse skin from topical application of creams with methyl 5-aminolevulinate (MAL) was studied.
Andrzej, Bugaj +5 more
openaire +4 more sources
Topical photodynamic therapy using different porphyrin precursors leads to differences in vascular photosensitization and vascular damage in normal mouse skin [PDF]
, 2014 Different distributions of hexyl aminolevulinate (HAL), aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) in the superficial vasculature are not well studied but they are hypothesized to play an important role in topical photodynamic therapy ...
Bruijn, H.S. (Riette) de +6 more
core +1 more source
The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device [PDF]
, 2016 Clinical TrialJournal ArticleAuthor's post-print is subject to a Creative Commons Attribution Non-Commercial No Derivatives LicenseTopical protoporphyrin (PpIX)-induced photodynamic therapy (PDT) relies on the penetration of the prodrug into the skin ...
Allen, James +5 more
core +1 more source
Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester
Medicina, 2009 Objective. The incidence of malignant skin tumors is rapidly increasing. Early diagnosis, determining the margins of the tumor, is extremely important to achieve good treatment results. We investigated fluorescence of protoporphyrin IX in skin carcinomas.
Navickienė, Jurgita +3 more
openaire +2 more sources
The importance of iron chelation and iron availability during PpIX-induced photodynamic therapy [PDF]
, 2015 This is the accepted version of the article. Please cite the published version which is available via the DOI link in this record.Background: Protoporphyrin IX (PpIX)-induced photodynamic therapy (PDT) is being utilised as a topical method of localised ...
Curnow, Alison, Pye, Andrew
core +1 more source
Pain in photodynamic therapy [PDF]
, 2016 Photodynamic therapy is a modern treatment with applications in several medical specialties, which has been intensely studied in the last years. The main indications in dermatology are actinic keratosis, superficial basal cell carcinoma and Bowen\u27s ...
Benea, Vasile +6 more
core +3 more sources
Current evidence and applications of photodynamic therapy in dermatology [PDF]
, 2014 In photodynamic therapy (PDT) a photosensitizer – a molecule that is activated by light – is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation ...
Lin, Jennifer Y, Wan, Marilyn T
core +2 more sources
Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification [PDF]
, 2016 Author's post-print is subject to a Creative Commons Attribution Non-Commercial No Derivatives LicenseBACKGROUND: Dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) is utilized to successfully treat dermatological conditions. This study
Campbell, Sandra M. +2 more
core +1 more source