Results 211 to 220 of about 12,458,805 (285)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

ETV7 promotes 5-FU resistance and malignant progression through CXCL1-induced NETs formation in colorectal cancer. [PDF]

Commun Biol
Mo S, Xia P, Lv Y, Liu L, He S, Gao H, Chen L, Wu J, Han A, Chen L.   +9 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Loperamide reverses 5‑FU resistance in colorectal cancer by activating autophagy. [PDF]

Oncol Rep
Yu J, An X, Qu X, Ke J, Rao H, Liu Y, Liu Z, Liu D, Jia J, Li S.   +9 more
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Comparative preventive effects of probiotic and postbiotic preparations of <i>Lacticaseibacillus rhamnosus</i> L156.4 and GG in a 5-FU-induced mucositis model. [PDF]

Gut Microbes Rep
Munis Campos G, Viegas Santos RC, Silva Quaresma L, Ferrary Américo M, Guimarães Sousa E, Gomes GC, Freitas ADS, Lima Barroso FA, Elias Moreira Júnior R, Brunialti Godard AL, de Souza RP, Ferreira E, Pires LO, Antunes Fernandes SO, Cardoso VN, Canário Viana MV, Figueiredo Siqueira MDS, Carvalho RDO, Lima de Jesus LC, Santos TM, Le Loir Y, Guédon E, Azevedo V.   +22 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

An injectable photo-crosslinking silk hydrogel system with biphasic release of BTXA and 5-Fu promotes scarless wound healing. [PDF]

RSC Adv
Xu M, Wang X, Zhou Z, Wang L, Zhou J, Hu X, Wang Y, Wu T.   +7 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source