Results 241 to 250 of about 9,064,090 (287)

Drug interactions between cephalosporins and 5-FU-based chemotherapy in the treatment of patients with gastrointestinal cancer - an exploratory cohort analysis. [PDF]

Front Pharmacol
Siegel R, Schlosser-Hupf S, Müller-Schilling M, Kharroubi SA, Gessner A, El-Najjar N.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

CF10 Displayed Improved Activity Relative to 5-FU in a Mouse CRLM Model Under Conditions of Physiological Folate. [PDF]

Cancers (Basel)
Okechukwu CC, Ma X, Li W, D'Agostino R, Rees MG, Ronan MM, Roth JA, Gmeiner WH.   +7 more
europepmc   +1 more source

Warfarin–5-FU interactions

Annals of Oncology, 2006
openaire   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Microcurrent stimulation induces cell death in p53-mutant and 5-FU-resistant breast cancer. [PDF]

J Biol Chem
Tanihara T, Yoshida Y, Ogino T, Terada Y, Tsurusaki F, Hamasaki K, Otsuki K, Fukuoka K, Oyama K, Tsuruta A, Hamamura K, Mayanagi K, Koyanagi S, Murakami Y, Ono M, Kuwano M, Ohdo S, Matsunaga N.   +17 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

USP39/SMC4 promotes hepatoma cell proliferation and 5-FU resistance. [PDF]

Sci Rep
Zhou B, Li J, Wu S, Zhang H, Luo Y, Chen J, Chen G.   +6 more
europepmc   +1 more source

Targeting DKC1/NF-κB axis suppresses tumorigenesis and enhances 5-FU sensitivity in gastric cancer. [PDF]

Cancer Cell Int
Wang T, Zhang H, Feng Y, Yang Y.
europepmc   +1 more source