Results 241 to 250 of about 12,458,805 (285)

Functional studies of human variants in C. elegans link iron metabolism to DPD deficiency and 5-FU sensitivity. [PDF]

Genetics
Li X, Menendez Perdomo IM, van Kuilenburg ABP, Tarailo-Graovac M.   +3 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The mTORC2 component SIN1 post-transcriptionally regulates TYMS levels and modulates P53 activity in response to 5-FU chemotherapy. [PDF]

Cell Commun Signal
Sayed AE, Gomes N, Zakrzewski M, Liudkovska V, Serwa R, Azzi A.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

5-FU Weakens Defensive Functions of the Junctional Epithelium. [PDF]

J Periodontal Res
Aellos F, Ramos A, Civit-Balta A, Grauer JA, Cuevas PL, Rao S, Yuan X, Liu B, Helms JA.   +8 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Secreted AZGP1 induced by 5-FU binds to PD-L1 and promotes apoptosis in cholangiocarcinoma. [PDF]

Mol Med
You JE, Kim DY, Yun H, Koh DI, Ryu YS, Jin DH.   +5 more
europepmc   +1 more source

Bioinspired pH-sensitive liposomes for quercetin delivery to synergize with 5- FU in gastric cancer therapy. [PDF]

Int J Pharm X
Lan Q, Wang M, Zhu Y, Zhang X, Ye R, Wu Z, Lan H, Luo S, Xu Y.   +8 more
europepmc   +1 more source

Warfarin–5-FU interactions

Annals of Oncology, 2006
openaire   +1 more source

Cascade-responsive HA-decorated liposome/mesoporous silica nanoplatform co-delivering BMF-219 and 5-FU enhances gastric cancer chemotherapy through Menin- and p53-associated apoptotic signaling. [PDF]

J Exp Clin Cancer Res
Wang S, Li D, Zeng F, Wang R, Ly C, Jiang J, Wang Z.   +6 more
europepmc   +1 more source