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Trends in Pharmacological Sciences, 1992
Recent experimental data, both in animals and the clinic, suggest that drugs selectively interacting with the 5-HT system may reduce alcohol intake. Although the precise mechanisms underlying these drug effects are unknown, it seems that there are at least two pharmacological strategies available, described in this review by Edward Sellers and ...
Sellers, Edward M. +2 more
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Recent experimental data, both in animals and the clinic, suggest that drugs selectively interacting with the 5-HT system may reduce alcohol intake. Although the precise mechanisms underlying these drug effects are unknown, it seems that there are at least two pharmacological strategies available, described in this review by Edward Sellers and ...
Sellers, Edward M. +2 more
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Higher-End Serotonin Receptors: 5-HT5, 5-HT6, and 5-HT7
Journal of Medicinal Chemistry, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
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Life Sciences, 1985
The ability of m-trifluoromethylphenylpiperazine (TFMPP) and an N-substituted derivative, LY 165163 (p-NH2-PE-TFMPP), to discriminate 5-HT-1 binding sites labelled by [3H]5-HT is compared in rat corpus striatum and rat cortex. TFMPP displays at least a 30 fold selectivity for the 5-HT-1b subtype. Furthermore, TFMPP reveals heterogeneity within the 5-HT-
Kenneth B. Asarch +2 more
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The ability of m-trifluoromethylphenylpiperazine (TFMPP) and an N-substituted derivative, LY 165163 (p-NH2-PE-TFMPP), to discriminate 5-HT-1 binding sites labelled by [3H]5-HT is compared in rat corpus striatum and rat cortex. TFMPP displays at least a 30 fold selectivity for the 5-HT-1b subtype. Furthermore, TFMPP reveals heterogeneity within the 5-HT-
Kenneth B. Asarch +2 more
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Role of Somatodendritic 5‐HT Autoreceptors in Modulating 5‐HT Neurotransmissiona
Annals of the New York Academy of Sciences, 1998ABSTRACT: A very important element controlling serotonin (5‐HT) release throughout the brain is the 5‐HT1A autoreceptor present on the soma and dendrites of 5‐HT neurons since it exerts a negative feedback influence on their firing activity. This 5‐HT1A autoreceptor receives an increased activation by endogenous 5‐HT at the beginning of a treatment ...
P, Blier +4 more
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Neuroscience & Biobehavioral Reviews, 1999
The study of 5-hydroxytryptamine (5-HT) system has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Growing evidence suggests that 5-HT is important in learning and memory and all its receptors might be implicated in this.
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The study of 5-hydroxytryptamine (5-HT) system has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Growing evidence suggests that 5-HT is important in learning and memory and all its receptors might be implicated in this.
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Serotonin (5-HT) transporter ligands affect plasma 5-HT in rats.
Annals of the New York Academy of Sciences, 2008Dual dopamine (DA)/serotonin (5-HT)-releasing agents are promising candidate medications for stimulant addiction and other disorders. However, certain 5-HT transporter (SERT) substrates are associated with development of idiopathic pulmonary arterial hypertension (IPAH) and valvular heart disease (VHD).
Richard B, Rothman +2 more
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Headache: The Journal of Head and Face Pain, 1994
SYNOPSIS Serotonin, or 5‐hydroxytryptamine [5‐HT], is a biogenic amine implicated in controlling feeding behavior, thermoregulation, sexual behavior, and sleep. 5‐HT receptors recognize at least three types of molecular structures: G protein coupled receptors, ligand gated ion channels, and transporters.
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SYNOPSIS Serotonin, or 5‐hydroxytryptamine [5‐HT], is a biogenic amine implicated in controlling feeding behavior, thermoregulation, sexual behavior, and sleep. 5‐HT receptors recognize at least three types of molecular structures: G protein coupled receptors, ligand gated ion channels, and transporters.
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Journal of Psychopharmacology, 1993
The discovery and clinical evolution of 5-HT re-uptake inhibiting drugs are reviewed. From the widespread distribution of 5-HT in bodily systems and the range of effects and side effects reported, it is concluded that these and other drugs active on the 5-HT system are likely to have beneficial effects on a range of other physical conditions ...
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The discovery and clinical evolution of 5-HT re-uptake inhibiting drugs are reviewed. From the widespread distribution of 5-HT in bodily systems and the range of effects and side effects reported, it is concluded that these and other drugs active on the 5-HT system are likely to have beneficial effects on a range of other physical conditions ...
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