Results 11 to 20 of about 714 (147)

Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex

Frontiers in Molecular Neuroscience, 2018
G-protein–coupled receptor (GPCR) heterodimers are new targets for the treatment of schizophrenia. Dopamine D2 receptors and serotonin 5-HT1A and 5-HT2A receptors play an important role in neurotransmission and have been implicated in many human ...
Marta Szlachta, Maciej Kuśmider, Paulina Pabian, Joanna Solich, Magdalena Kolasa, Dariusz Żurawek, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka   +7 more
doaj   +1 more source

Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor

Journal of Pharmacological Sciences, 2010
Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects ...
Eun-Joo Shin, Wan Kyunn Whang, Sungun Kim, Jae-Hyung Bach, Jin-Man Kim, Xuan-Khanh Thi Nguyen, Thuy-Ty Lan Nguyen, Bae Dong Jung, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim   +10 more
doaj   +1 more source

Receptor–Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

Molecules, 2018
Due to the binding to a number of proteins to the receptor protomers in receptor heteromers in the brain, the term “heteroreceptor complexes” was introduced.
Dasiel O. Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fuxe   +14 more
doaj   +1 more source

Drosophila insulin-producing cells are differentially modulated by serotonin and octopamine receptors and affect social behavior. [PDF]

PLoS ONE, 2014
A set of 14 insulin-producing cells (IPCs) in the Drosophila brain produces three insulin-like peptides (DILP2, 3 and 5). Activity in IPCs and release of DILPs is nutrient dependent and controlled by multiple factors such as fat body-derived proteins ...
Jiangnan Luo, Oleh V Lushchak, Philip Goergen, Michael J Williams, Dick R Nässel   +4 more
doaj   +1 more source

Towards in vivo imaging of functionally active 5-HT1A receptors in schizophrenia: concepts and challenges

Translational Psychiatry, 2021
The serotonin 5-HT1A receptor has attracted wide attention as a target for treatment of psychiatric disorders. Although this receptor is important in the pharmacological mechanisms of action of new-generation antipsychotics, its characterization remains ...
Oriane Razakarivony, Adrian Newman-Tancredi, Luc Zimmer   +2 more
doaj   +1 more source

5-HT1A Receptor Function Makes Wound Healing a Happier Process

Frontiers in Pharmacology, 2018
Skin wound healing is a multistage phenomenon that is regulated by cell–cell interplay and various factors. Endogenous serotonin is an important neurotransmitter and cytokine.
Alia Sadiq, Alia Sadiq, Alia Sadiq, Isabella Menchetti, Ahmed Shah, Ahmed Shah, Marc G. Jeschke, Marc G. Jeschke, Marc G. Jeschke, Marc G. Jeschke, Marc G. Jeschke, Cassandra Belo, Wendolyn Carlos-Alcalde, Wendolyn Carlos-Alcalde, Muhammad Qasim Hayat, Saeid Amini-Nik, Saeid Amini-Nik, Saeid Amini-Nik, Saeid Amini-Nik   +18 more
doaj   +1 more source

Occupancy of Agonist Drugs at the 5-HT1A Receptor [PDF]

Neuropsychopharmacology, 2003
Drugs acting on the 5-HT1A receptor are used in the treatment of depression, generalized anxiety disorder, and schizophrenia. This study investigated 5-HT1A receptor occupancy by the 5-HT1A agonist drugs flesinoxan (a highly selective probe for the 5-HT1A receptor) and ziprasidone (a novel atypical antipsychotic drug). Using a within-subject design, 14
R Alexander, Bantick, Eugenii A, Rabiner, Ella, Hirani, Michiel H, de Vries, Susan P, Hume, Paul M, Grasby   +5 more
openaire   +2 more sources

Hippocampal 5-HT1A receptor and spatial learning and memory

Frontiers in Pharmacology, 2015
Spatial cognition is fundamental for survival in the topographically complex environments inhabited by humans and other animals. The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5 ...
Yifat eGlikmann-Johnston, Yifat eGlikmann-Johnston, Michael Martin Saling, Michael Martin Saling, David C Reutens, Julie C Stout   +5 more
doaj   +1 more source

The 5-HT1A receptor in Major Depressive Disorder [PDF]

European Neuropsychopharmacology, 2016
Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is associated with a high degree of morbidity and mortality. This debilitating disorder is currently one of the leading causes of disability nationwide and is predicted to be the leading cause of disease burden by the year 2030.
Joshua, Kaufman, Christine, DeLorenzo, Sunia, Choudhury, Ramin V, Parsey   +3 more
openaire   +2 more sources

Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder

Frontiers in Psychiatry, 2019
Aims: Serotonin 1A receptor (5-HT1A) and vascular endothelial growth factor (VEGF) are widely expressed in the neurons of the hippocampus and have significant roles in the pathophysiological processes of major depressive disorders (MDDs).
Dong Han, Zhengxue Qiao, Dong Qi, Jiarun Yang, Xiuxian Yang, Jingsong Ma, Lin Wang, Xuejia Song, Erying Zhao, Jian Zhang, Yanjie Yang, Xiaohui Qiu   +11 more
doaj   +1 more source