Results 21 to 30 of about 78,996,387 (176)

5-HT1A Receptor Function Makes Wound Healing a Happier Process

Frontiers in Pharmacology, 2018
Skin wound healing is a multistage phenomenon that is regulated by cell–cell interplay and various factors. Endogenous serotonin is an important neurotransmitter and cytokine.
Alia Sadiq, Alia Sadiq, Alia Sadiq, Isabella Menchetti, Ahmed Shah, Ahmed Shah, Marc G. Jeschke, Marc G. Jeschke, Marc G. Jeschke, Marc G. Jeschke, Marc G. Jeschke, Cassandra Belo, Wendolyn Carlos-Alcalde, Wendolyn Carlos-Alcalde, Muhammad Qasim Hayat, Saeid Amini-Nik, Saeid Amini-Nik, Saeid Amini-Nik, Saeid Amini-Nik   +18 more
doaj   +1 more source

Occupancy of Agonist Drugs at the 5-HT1A Receptor [PDF]

Neuropsychopharmacology, 2003
Drugs acting on the 5-HT1A receptor are used in the treatment of depression, generalized anxiety disorder, and schizophrenia. This study investigated 5-HT1A receptor occupancy by the 5-HT1A agonist drugs flesinoxan (a highly selective probe for the 5-HT1A receptor) and ziprasidone (a novel atypical antipsychotic drug). Using a within-subject design, 14
R Alexander, Bantick, Eugenii A, Rabiner, Ella, Hirani, Michiel H, de Vries, Susan P, Hume, Paul M, Grasby   +5 more
openaire   +2 more sources

Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder

Frontiers in Psychiatry, 2019
Aims: Serotonin 1A receptor (5-HT1A) and vascular endothelial growth factor (VEGF) are widely expressed in the neurons of the hippocampus and have significant roles in the pathophysiological processes of major depressive disorders (MDDs).
Dong Han, Zhengxue Qiao, Dong Qi, Jiarun Yang, Xiuxian Yang, Jingsong Ma, Lin Wang, Xuejia Song, Erying Zhao, Jian Zhang, Yanjie Yang, Xiaohui Qiu   +11 more
doaj   +1 more source

The 5-HT1A receptor in Major Depressive Disorder [PDF]

European Neuropsychopharmacology, 2016
Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is associated with a high degree of morbidity and mortality. This debilitating disorder is currently one of the leading causes of disability nationwide and is predicted to be the leading cause of disease burden by the year 2030.
Joshua, Kaufman, Christine, DeLorenzo, Sunia, Choudhury, Ramin V, Parsey   +3 more
openaire   +2 more sources

Dual actions of 5‐MeO‐DIPT at the serotonin transporter and serotonin 5‐HT1A receptor in the mouse striatum and prefrontal cortex

Neuropsychopharmacology Reports, 2021
Aims 5‐Methoxy‐N,N‐diisopropyltryptamine (5‐MeO‐DIPT) is a synthetic orally active hallucinogenic tryptamine analogue. The present study examined whether the effects of 5‐MeO‐DIPT involve the serotonin transporter (SERT) and serotonin 5‐hydroxytryptamine‐
Yoko Hagino, Frank Scott Hall, George R. Uhl, Ichiro Sora, Kazutaka Ikeda   +4 more
doaj   +1 more source

Involvement of 5-HT1A/1B receptors in the antinociceptive effect of paracetamol in the rat formalin test

Neurobiology of Pain, 2018
The mechanism of analgesic action of paracetamol (acetominophen) remains still unknown. However, a relationship between serotonergic system and the effect of paracetamol has been previously demonstrated.
A. Roca-Vinardell, E. Berrocoso, M. Llorca-Torralba, J.A. García-Partida, J. Gibert-Rahola, J.A. Mico   +5 more
doaj   +1 more source

1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands

, 2005
A series of new 1,2,4-benzothiadiazine derivatives with an arylpiperazine mojety linked at position 3 of the heterocyclic ringwere synthesized and assessed for their pharmacological profiles at a1-adrenoceptor subtypes (a1A, a1B and a1D) by functional ...
BRASILI L., LUPPI A, TAIT A, POGGESI E, MARUCCI, Gabriella, PREZIOSI E, FRANCHINI S, BUCCIONI, Michela, PARENTI C, LEONARDI A   +9 more
core   +3 more sources

Cannabidiol Acts at 5-HT1A Receptors in the Human Brain: Relevance for Treating Temporal Lobe Epilepsy

Frontiers in Behavioral Neuroscience, 2020
Experimental evidence indicates that cannabidiol (CBD) induces anxiolytic and antiepileptic effects through the activation of 5-HT1A receptors. These receptors are coupled to Gi/o proteins and induce inhibitory effects. At present, the interaction of CBD
Christopher Martínez-Aguirre, Francia Carmona-Cruz, Ana Luisa Velasco, Francisco Velasco, Gustavo Aguado-Carrillo, Manola Cuéllar-Herrera, Luisa Rocha   +6 more
doaj   +1 more source

Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls

Molecular Brain, 2021
The neurotransmitter serotonin, involved in the regulation of pain and emotion, is critically regulated by the 5‐HT1A autoreceptor and the serotonin transporter (5-HTT).
Isabel Ellerbrock, Angelica Sandström, Jeanette Tour, Silvia Fanton, Diana Kadetoff, Martin Schalling, Karin B. Jensen, Rouslan Sitnikov, Eva Kosek   +8 more
doaj   +1 more source

Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness

Molecular Brain, 2011
The serotonin-1A (5-HT1A) receptor is among the most abundant and widely distributed 5-HT receptors in the brain, but is also expressed on serotonin neurons as an autoreceptor where it plays a critical role in regulating the activity of the entire ...
Albert Paul R, Le François Brice, Millar Anne M   +2 more
doaj   +1 more source