Results 1 to 10 of about 79,681,589 (222)
Functional consequences of a rare human serotonergic 5-HT1A receptor variant [PDF]
Frontiers in Pharmacology, 2023 Serotonin (5-HT) plays a central role in various brain functions via the activation of a family of receptors, most of them G protein coupled receptors (GPCRs).
Merav Tauber, Yair Ben-Chaim
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5-HT1A Receptor Function Makes Wound Healing a Happier Process [PDF]
Frontiers in Pharmacology, 2018 Skin wound healing is a multistage phenomenon that is regulated by cell–cell interplay and various factors. Endogenous serotonin is an important neurotransmitter and cytokine.
Alia Sadiq +18 more
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Expression of the serotonin 1A receptor in the horse brain
Journal of Animal Reproduction and Biotechnology, 2023 Background: Serotonin receptors can be divided into seven different families with various subtypes. The serotonin 1A (5-HT1A) receptor is one of the most abundant subtypes in animal brains.
Yeonju Choi, Minjung Yoon
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Frontiers in Pharmacology, 2022 The reduced antidepressant and antihyperalgesic effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine during maintenance treatment has been reported, but little is known about the molecular mechanism of this phenomenon.
Jiajia Dai +9 more
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5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability
iScience, 2023 Summary: Many psychiatric diseases have been associated with serotonin (5-HT) neuron dysfunction. The firing of 5-HT neurons is known to be under 5-HT1A receptor-mediated autoinhibition, but functional consequences of coexpressed receptors are unknown ...
Amina Benhadda +8 more
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Frontiers in Public Health, 2022 The nervous system is a sensitive target of electromagnetic radiation (EMR). Chronic microwave exposure can induce cognitive deficits, and 5-HT system is involved in this effect. Genetic polymorphisms lead to individual differences.
Haijuan Li +10 more
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Neurobiology of Disease, 2021 Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder that affects movement coordination leading to a premature death. Despite several efforts, no disease-modifying treatment is yet available for
Joana Pereira-Sousa +9 more
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Pharmaceutical Fronts, 2022 Evidence suggested that the use of partial dopamine D2/D3 receptor agonists may be a better choice for the treatment of Parkinson's disease (PD), and the stimulation of 5-HT1A receptors (mainly via nondopaminergic mechanisms) alleviates motor and ...
Xin-Li Du +7 more
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Frontiers in Pharmacology, 2022 Cannabidiol (CBD), the main non-psychoactive cannabinoid found in the cannabis plant, elicits several pharmacological effects via the 5-HT1A receptor. The dorsal raphe nucleus (DRN) is the main serotonergic cluster in the brain that expresses the 5-HT1A ...
Aitziber Mendiguren +4 more
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Frontiers in Behavioral Neuroscience, 2020 Brain serotonin (5-HT) neurotransmission plays an important role in male sexual behavior and it is well established that activating 5-HT1A receptors in rats facilitate ejaculatory behavior.
Diana Carolina Esquivel-Franco +8 more
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