5-HT1A Receptor Function Makes Wound Healing a Happier Process [PDF]
Frontiers in Pharmacology, 2018 Skin wound healing is a multistage phenomenon that is regulated by cell–cell interplay and various factors. Endogenous serotonin is an important neurotransmitter and cytokine.
Alia Sadiq +18 more
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Functional consequences of a rare human serotonergic 5-HT1A receptor variant [PDF]
Frontiers in Pharmacology, 2023 Serotonin (5-HT) plays a central role in various brain functions via the activation of a family of receptors, most of them G protein coupled receptors (GPCRs).
Merav Tauber, Yair Ben-Chaim
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Structural Pharmacology of Bufotenine Derivatives in Activating the 5-HT1A Receptor for Therapeutic Potential in Depression and Anxiety [PDF]
ResearchThe 5-HT1A receptor is a critical target in the treatment of depression and anxiety. Bufotenine derivatives, such as 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), 5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), and 5-hydroxy-N,N,N-dimethyltryptamine—derived
Shu-jie Li +16 more
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Molecules, 2018 Due to the binding to a number of proteins to the receptor protomers in receptor heteromers in the brain, the term “heteroreceptor complexes” was introduced.
Dasiel O. Borroto-Escuela +14 more
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Cannabigerol modulates α2-adrenoceptor and 5-HT1A receptor-mediated electrophysiological effects on dorsal raphe nucleus and locus coeruleus neurons and anxiety behavior in rat [PDF]
Frontiers in Pharmacology, 2023 The pharmacological profile of cannabigerol (CBG), which acid form constitutes the main precursor of the most abundant cannabinoids, has been scarcely studied. It has been reported to target α2-adrenoceptor and 5-HT1A receptor.
Aitziber Mendiguren +5 more
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Nicotine and fluoxetine alter adolescent dopamine-mediated behaviors via 5-HT1A receptor activation [PDF]
Frontiers in PsychiatryIntroductionAbuse or misuse of tobacco, e-cigarettes, or antidepressants may have serious clinical consequences during adolescence, a sensitive period during brain development when the distinct neurobiology of adolescent serotonin (5-HT) and dopamine (DA)
Menglu Yuan, Frances M. Leslie
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Augmentation Therapy With Serotonin 5‐HT1A Receptor Partial Agonists on Cognitive Function in Depressive Disorders: A Systematic Review of Randomized Controlled Studies [PDF]
Neuropsychopharmacology ReportsObjective The use of serotonin 5‐HT1A receptor partial agonists (5‐HT1A‐PAs) as an add‐on therapy has been associated with the enhancement of attention/processing speed in patients with schizophrenia. Also, 5‐HT1A receptors have been shown to play a role
Risa Yamada +4 more
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Astrocytic 5-HT1A receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice [PDF]
Experimental and Molecular MedicineNMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. Although the underlying mechanisms remain unclear, this form of LTD cannot be induced
Qian-Yun Wu +7 more
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Expression of the serotonin 1A receptor in the horse brain
Journal of Animal Reproduction and Biotechnology, 2023 Background: Serotonin receptors can be divided into seven different families with various subtypes. The serotonin 1A (5-HT1A) receptor is one of the most abundant subtypes in animal brains.
Yeonju Choi, Minjung Yoon
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Frontiers in Pharmacology, 2022 The reduced antidepressant and antihyperalgesic effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine during maintenance treatment has been reported, but little is known about the molecular mechanism of this phenomenon.
Jiajia Dai +9 more
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