Results 41 to 50 of about 167,641 (233)

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Avaliação da participação do receptor 5-HT1A pós-sináptico na hipofagia induzida pela injeção de 8-OH-DPAT na área hipotalâmica lateral [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa Multicêntrico de Pós-Graduação em Ciências FisiológicasEstudos conduzidos em nosso laboratório avaliaram os efeitos da injeção local de 8-hidroxi-2 ...
Lavado, Cristiane
core  

Molecular and pharmacological characterization of serotonin 5-HT2α and 5-HT7 receptors in the salivary glands of the blowfly calliphora vicina [PDF]

, 2012
Secretion in blowfly (Calliphora vicina) salivary glands is stimulated by the biogenic amine serotonin (5-hydroxytryptamine, 5-HT), which activates both inositol 1,4,5-trisphosphate (InsP3)/Ca2+ and cyclic adenosine 3′,5′-monophosphate (cAMP) signalling ...
Walz, Bernd, Bernd Walz, Baumann, Otto, Claudia Röser, Nadine Jordan (120821), Röser,C., Bernd Walz (48845), Wolfgang Blenau, Balfanz, Sabine, Otto Baumann (48844), Blenau, Wolfgang, Baumann, A., Sabine Balfanz (120824), Jordan, Nadine, Baumann, Arnd, Sabine Balfanz, Arnd Baumann, Blenau, Wolfgang (Dr.), Claudia Röser (120818), Wolfgang Blenau (120829), Nadine Jordan, Otto Baumann, Röser, Claudia, Arnd Baumann (120826)   +23 more
core   +1 more source

Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking [PDF]

, 2012
Serotonin receptors 5-HT1A and 5-HT7 are highly coexpressed in brain regions implicated in depression. However, their functional interaction has not been established.
Fröhlich, M., Dityatev, A., Guseva, D., Gorinski, N., Renner, U., Doering, F., Ponimaskin, E.G., Richter, D.W., Ponimaskin, E., Döring, F., Niebert, M., Wischmeyer, E., Neher, E., Abdel-Galil, D., Froehlich, M., Zeug, A., Richter, D., Dityateva, G., Woehler, A.   +18 more
core   +2 more sources

Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock

Journal of Pharmacological Sciences, 2013
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet ...
Kazumasa Horikawa, Kazuyuki Fuji, Yuka Fukazawa, Shigenobu Shibata   +3 more
doaj   +1 more source

Drosophila insulin-producing cells are differentially modulated by serotonin and octopamine receptors and affect social behavior. [PDF]

PLoS ONE, 2014
A set of 14 insulin-producing cells (IPCs) in the Drosophila brain produces three insulin-like peptides (DILP2, 3 and 5). Activity in IPCs and release of DILPs is nutrient dependent and controlled by multiple factors such as fat body-derived proteins ...
Jiangnan Luo, Oleh V Lushchak, Philip Goergen, Michael J Williams, Dick R Nässel   +4 more
doaj   +1 more source

Selective Targeting of Serotonin 5-HT1a and 5-HT3 Receptors Attenuates Acute and Long-Term Hypersensitivity Associated With Neonatal Procedural Pain

Frontiers in Pain Research, 2022
Neonatal painful procedures causes acute pain and trigger long-term changes in nociceptive processing and anxiety behavior, highlighting the need for adequate analgesia during this critical time.
Anne R. de Kort, Anne R. de Kort, Elbert A. Joosten, Elbert A. Joosten, Jacob Patijn, Jacob Patijn, Dick Tibboel, Nynke J. van den Hoogen, Nynke J. van den Hoogen, Nynke J. van den Hoogen   +9 more
doaj   +1 more source

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

O papel dos receptores 5-HT1A nas respostas ingestivas e hipnogênica provocadas pela injeção intracerebroventricular de serotonina em pombos (Columba livia): discriminação entre receptores pré e pós-sinápticos [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.Introdução: diversos estudos demonstram que os circuitos serotonérgicos inibem a ingestão de ...
Santos, Tiago Souza dos
core  

Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats

Journal of Pharmacological Sciences, 2018
We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats.
Yuka Nakamura, Yoshihisa Kitamura, Yusuke Sumiyoshi, Nanami Naito, Shiho Kan, Soichiro Ushio, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo   +8 more
doaj   +1 more source