Results 31 to 40 of about 79,681,589 (222)

Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling

Frontiers in Neuroscience, 2020
BackgroundMajor depressive disorder (MDD) is a severe mental disorder related to the deficiency of monoamine neurotransmitters, particularly to abnormalities of 5-HT (5-hydroxytryptamine, serotonin) and its receptors.
Jianxin Li, Ling Chen, Gaowen Li, Gaowen Li, Xiaojuan Chen, Sisi Hu, Liang Zheng, Victor Luria, Jinpeng Lv, Jinpeng Lv, Yindi Sun, Ying Xu, Yingcong Yu   +12 more
doaj   +1 more source

WAY-100635 Alleviates Corneal Lesions Through 5-HT1A Receptor-ROS-Autophagy Axis in Dry Eye

Frontiers in Medicine, 2021
Purpose: To explore whether 5-HT1A receptors are involved in the dry eye disease (DED) mouse model and reveal its underlying mechanism.Methods: A C57BL/6J mouse DED model was established via the administration of 0.2% benzalkonium chloride twice a day ...
Xujiao Zhou, Yiqin Dai, Zimeng Zhai, Jiaxu Hong, Jiaxu Hong   +4 more
doaj   +1 more source

Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain -- a combined in situ hybridisation/in vitro receptor autoradiographic study [PDF]

, 1991
The present study examined the comparative distribution of 5-HT1A receptor mRNA and 5-HT1A receptors in rat brain using a combination of in situ hybridisation histochemistry and in vitro receptor autoradiography. 5-HT1A mRNA was visualised using a 910 bp
Chalmers, Derek T., Watson, Stanley J.
core   +1 more source

Discovery of a new series of 5-HT1A receptor agonists

, 2010
Starting from compounds previously identified as a1-adrenoceptor antagonists that were also found to bind to the 5-HT1A receptor, in an attempt to separate the two activities, a new series of 5-HT1A receptor agonists was identified and shown to have ...
BRASILI L., ANGELI P, FOSSA, PAOLA, TAIT A, POGGESI E, PRANDI A, SORBI C, BUCCIONI M, FRANCHINI S, CILIA A, BARALDI A   +10 more
core   +2 more sources

Cannabigerol modulates α2-adrenoceptor and 5-HT1A receptor-mediated electrophysiological effects on dorsal raphe nucleus and locus coeruleus neurons and anxiety behavior in rat

Frontiers in Pharmacology, 2023
The pharmacological profile of cannabigerol (CBG), which acid form constitutes the main precursor of the most abundant cannabinoids, has been scarcely studied. It has been reported to target α2-adrenoceptor and 5-HT1A receptor.
Aitziber Mendiguren, Erik Aostri, Irati Rodilla, Iker Pujana, Ekaterina Noskova, Joseba Pineda   +5 more
doaj   +1 more source

On the existence and function of galanin receptor heteromers in the Central Nervous System

Frontiers in Endocrinology, 2012
Galanin receptor (GalR) subtypes1-3 linked to central galanin neurons may form heteromers with each other and other types of G protein coupled receptors (GPCRs) in the Central Nervous System (CNS).
Kjell eFuxe, Dasiel Oscar Borroto-Escuela, Wilber eRomero-Fernandez, Alexander O Tarakanov, Feliciano eCalvo, Pere eGarriga, Mercé eTena, Manuel eNarvaez, Carmelo eMillón, Concepción eParrado, Francisco eCiruela, Luigi Francesco Agnati, José Angel Narvaéz, Zaida eDiaz Cabiale   +13 more
doaj   +1 more source

[18F]MPPF and [18F]FDG μPET imaging in rats: impact of transport and restraint stress

EJNMMI Research, 2020
Background Stress exposure can significantly affect serotonergic signaling with a particular impact on 5-HT1A receptor expression. Positron emission tomography (PET) provides opportunities for molecular imaging of alterations in 5-HT1A receptor binding ...
Verena Buchecker, Ann-Marie Waldron, R. Maarten van Dijk, Ines Koska, Matthias Brendel, Barbara von Ungern-Sternberg, Simon Lindner, Franz Josef Gildehaus, Sibylle Ziegler, Peter Bartenstein, Heidrun Potschka   +10 more
doaj   +1 more source

Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice

Journal of Pharmacological Sciences, 2015
We have found that fluvoxamine-induced increases in prefrontal dopamine release are enhanced by adrenalectomy/castration and 5-HT1A receptors are involved in the enhancement.
Shigeru Hasebe, Naoki Hiramatsu, Yukio Ago, Kazuya Mori, Yuji Watabe, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda   +7 more
doaj   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Modulação das funções do sistema glutamatérgico pelo receptor serotoninérgico 5-HT1A da substância cinzenta periaquedutal dorsal no comportamento defensivo de ratos [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Vários estudos têm caracterizado o envolvimento da substância cinzenta periaquedutal dorsal (SCPd) nas respostas ...
Moraes, Cladis Loren Kiefer
core