Results 31 to 40 of about 167,641 (233)

Epigenetic Regulation of Resistance to Emotional Stress: Possible Involvement of 5-HT1A Receptor–Mediated Histone Acetylation

Journal of Pharmacological Sciences, 2014
.: The ability to resist stress is an important defensive function of a living body. Thus, elucidation of the mechanisms by which the brain resists stress could help to pave the way for new therapeutic strategies for stress-related psychiatric disorders ...
Minoru Tsuji, Kazuya Miyagawa, Hiroshi Takeda   +2 more
doaj   +1 more source

Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling

Frontiers in Neuroscience, 2020
BackgroundMajor depressive disorder (MDD) is a severe mental disorder related to the deficiency of monoamine neurotransmitters, particularly to abnormalities of 5-HT (5-hydroxytryptamine, serotonin) and its receptors.
Jianxin Li, Ling Chen, Gaowen Li, Gaowen Li, Xiaojuan Chen, Sisi Hu, Liang Zheng, Victor Luria, Jinpeng Lv, Jinpeng Lv, Yindi Sun, Ying Xu, Yingcong Yu   +12 more
doaj   +1 more source

WAY-100635 Alleviates Corneal Lesions Through 5-HT1A Receptor-ROS-Autophagy Axis in Dry Eye

Frontiers in Medicine, 2021
Purpose: To explore whether 5-HT1A receptors are involved in the dry eye disease (DED) mouse model and reveal its underlying mechanism.Methods: A C57BL/6J mouse DED model was established via the administration of 0.2% benzalkonium chloride twice a day ...
Xujiao Zhou, Yiqin Dai, Zimeng Zhai, Jiaxu Hong, Jiaxu Hong   +4 more
doaj   +1 more source

Dual actions of 5‐MeO‐DIPT at the serotonin transporter and serotonin 5‐HT1A receptor in the mouse striatum and prefrontal cortex

Neuropsychopharmacology Reports, 2021
Aims 5‐Methoxy‐N,N‐diisopropyltryptamine (5‐MeO‐DIPT) is a synthetic orally active hallucinogenic tryptamine analogue. The present study examined whether the effects of 5‐MeO‐DIPT involve the serotonin transporter (SERT) and serotonin 5‐hydroxytryptamine‐
Yoko Hagino, Frank Scott Hall, George R. Uhl, Ichiro Sora, Kazutaka Ikeda   +4 more
doaj   +1 more source

On the existence and function of galanin receptor heteromers in the Central Nervous System

Frontiers in Endocrinology, 2012
Galanin receptor (GalR) subtypes1-3 linked to central galanin neurons may form heteromers with each other and other types of G protein coupled receptors (GPCRs) in the Central Nervous System (CNS).
Kjell eFuxe, Dasiel Oscar Borroto-Escuela, Wilber eRomero-Fernandez, Alexander O Tarakanov, Feliciano eCalvo, Pere eGarriga, Mercé eTena, Manuel eNarvaez, Carmelo eMillón, Concepción eParrado, Francisco eCiruela, Luigi Francesco Agnati, José Angel Narvaéz, Zaida eDiaz Cabiale   +13 more
doaj   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Farideh A. Javid, Javid, Farideh A., Mashhadi, Farzaneh Farajian, Robert J. Naylor, Farzaneh Farajian Mashhadi, Naylor, Robert J.   +5 more
core   +1 more source

Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice

Journal of Pharmacological Sciences, 2015
We have found that fluvoxamine-induced increases in prefrontal dopamine release are enhanced by adrenalectomy/castration and 5-HT1A receptors are involved in the enhancement.
Shigeru Hasebe, Naoki Hiramatsu, Yukio Ago, Kazuya Mori, Yuji Watabe, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda   +7 more
doaj   +1 more source

[18F]MPPF and [18F]FDG μPET imaging in rats: impact of transport and restraint stress

EJNMMI Research, 2020
Background Stress exposure can significantly affect serotonergic signaling with a particular impact on 5-HT1A receptor expression. Positron emission tomography (PET) provides opportunities for molecular imaging of alterations in 5-HT1A receptor binding ...
Verena Buchecker, Ann-Marie Waldron, R. Maarten van Dijk, Ines Koska, Matthias Brendel, Barbara von Ungern-Sternberg, Simon Lindner, Franz Josef Gildehaus, Sibylle Ziegler, Peter Bartenstein, Heidrun Potschka   +10 more
doaj   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Modulação das funções do sistema glutamatérgico pelo receptor serotoninérgico 5-HT1A da substância cinzenta periaquedutal dorsal no comportamento defensivo de ratos [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Vários estudos têm caracterizado o envolvimento da substância cinzenta periaquedutal dorsal (SCPd) nas respostas ...
Moraes, Cladis Loren Kiefer
core