Results 11 to 20 of about 167,641 (233)
Hippocampal 5-HT1A receptor and spatial learning and memory [PDF]
Frontiers in Pharmacology, 2015 Spatial cognition is fundamental for survival in the topographically complex environments inhabited by humans and other animals. The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5 ...
Yifat eGlikmann-Johnston +5 more
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5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability
iScience, 2023 Summary: Many psychiatric diseases have been associated with serotonin (5-HT) neuron dysfunction. The firing of 5-HT neurons is known to be under 5-HT1A receptor-mediated autoinhibition, but functional consequences of coexpressed receptors are unknown ...
Amina Benhadda +8 more
doaj +2 more sources
Existence of Brain 5‑HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5‑HT1A Receptor Recognition [PDF]
ACS Omega, 2017 Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their 5-HT receptor subtypes and collateral networks to the forebrain contribute to the etiology of major depression and are ...
Dasiel O. Borroto-Escuela +13 more
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Frontiers in Public Health, 2022 The nervous system is a sensitive target of electromagnetic radiation (EMR). Chronic microwave exposure can induce cognitive deficits, and 5-HT system is involved in this effect. Genetic polymorphisms lead to individual differences.
Haijuan Li +10 more
doaj +1 more source
Neurobiology of Disease, 2021 Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder that affects movement coordination leading to a premature death. Despite several efforts, no disease-modifying treatment is yet available for
Joana Pereira-Sousa +9 more
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Pharmaceutical Fronts, 2022 Evidence suggested that the use of partial dopamine D2/D3 receptor agonists may be a better choice for the treatment of Parkinson's disease (PD), and the stimulation of 5-HT1A receptors (mainly via nondopaminergic mechanisms) alleviates motor and ...
Xin-Li Du +7 more
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Frontiers in Pharmacology, 2022 Cannabidiol (CBD), the main non-psychoactive cannabinoid found in the cannabis plant, elicits several pharmacological effects via the 5-HT1A receptor. The dorsal raphe nucleus (DRN) is the main serotonergic cluster in the brain that expresses the 5-HT1A ...
Aitziber Mendiguren +4 more
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Frontiers in Behavioral Neuroscience, 2020 Brain serotonin (5-HT) neurotransmission plays an important role in male sexual behavior and it is well established that activating 5-HT1A receptors in rats facilitate ejaculatory behavior.
Diana Carolina Esquivel-Franco +8 more
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Occupancy of Agonist Drugs at the 5-HT1A Receptor [PDF]
Neuropsychopharmacology, 2003 Drugs acting on the 5-HT1A receptor are used in the treatment of depression, generalized anxiety disorder, and schizophrenia. This study investigated 5-HT1A receptor occupancy by the 5-HT1A agonist drugs flesinoxan (a highly selective probe for the 5-HT1A receptor) and ziprasidone (a novel atypical antipsychotic drug). Using a within-subject design, 14
R Alexander, Bantick +5 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2010 Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects ...
Eun-Joo Shin +10 more
doaj +1 more source