Results 11 to 20 of about 79,681,589 (222)

Hippocampal 5-HT1A receptor and spatial learning and memory [PDF]

Frontiers in Pharmacology, 2015
Spatial cognition is fundamental for survival in the topographically complex environments inhabited by humans and other animals. The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5 ...
Yifat eGlikmann-Johnston, Yifat eGlikmann-Johnston, Michael Martin Saling, Michael Martin Saling, David C Reutens, Julie C Stout   +5 more
doaj   +3 more sources

Structural Pharmacology of Bufotenine Derivatives in Activating the 5-HT1A Receptor for Therapeutic Potential in Depression and Anxiety [PDF]

Research
The 5-HT1A receptor is a critical target in the treatment of depression and anxiety. Bufotenine derivatives, such as 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), 5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), and 5-hydroxy-N,N,N-dimethyltryptamine—derived
Shu-jie Li, Qing-ning Yuan, Wen-yuan Wu, Zhi-han Chen, Duo Chen, Hong Shan, Qin-yu Chu, Wen Hu, Kai Wu, Tao Liu, Yu-yu Zhu, Li Hou, Jing Zhou, Jia Duan, Jin-ao Duan, H. Eric Xu, Hong-yue Ma   +16 more
doaj   +2 more sources

Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy

Frontiers in Neuroscience, 2010
Major depression is the most common form of mental illness, and is treated with antidepressant compounds that increase serotonin (5-HT) neurotransmission.
Paul R Albert, Brice Le François
doaj   +2 more sources

Nicotine and fluoxetine alter adolescent dopamine-mediated behaviors via 5-HT1A receptor activation [PDF]

Frontiers in Psychiatry
IntroductionAbuse or misuse of tobacco, e-cigarettes, or antidepressants may have serious clinical consequences during adolescence, a sensitive period during brain development when the distinct neurobiology of adolescent serotonin (5-HT) and dopamine (DA)
Menglu Yuan, Frances M. Leslie
doaj   +2 more sources

Augmentation Therapy With Serotonin 5‐HT1A Receptor Partial Agonists on Cognitive Function in Depressive Disorders: A Systematic Review of Randomized Controlled Studies [PDF]

Neuropsychopharmacology Reports
Objective The use of serotonin 5‐HT1A receptor partial agonists (5‐HT1A‐PAs) as an add‐on therapy has been associated with the enhancement of attention/processing speed in patients with schizophrenia. Also, 5‐HT1A receptors have been shown to play a role
Risa Yamada, Ayumu Wada, Andrew Stickley, Adrian Newman‐Tancredi, Tomiki Sumiyoshi   +4 more
doaj   +2 more sources

Astrocytic 5-HT1A receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice [PDF]

Experimental and Molecular Medicine
NMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. Although the underlying mechanisms remain unclear, this form of LTD cannot be induced
Qian-Yun Wu, Lian-Hong Lin, Kun Lu, Si-Fu Deng, Wei-Min Li, Yuan Xu, Bin Zhang, Ji-Hong Liu   +7 more
doaj   +2 more sources

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Javid, Farideh A., Mashhadi, Farzaneh Farajian, Naylor, Robert J.   +2 more
core   +5 more sources

Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking [PDF]

, 2012
Serotonin receptors 5-HT1A and 5-HT7 are highly coexpressed in brain regions implicated in depression. However, their functional interaction has not been established.
Fröhlich, M., Dityatev, A., Guseva, D., Gorinski, N., Renner, U., Doering, F., Ponimaskin, E.G., Richter, D.W., Ponimaskin, E., Döring, F., Niebert, M., Wischmeyer, E., Neher, E., Abdel-Galil, D., Froehlich, M., Zeug, A., Richter, D., Dityateva, G., Woehler, A., Zeug, Andre, Niebert, Markus, Ponimaskin, Evgeni G., Gorinski, Nataliya, Guseva, Daria, Abdel-Galil, Dalia, Renner, Ute, Fröhlich, Matthias, Woehler, Andrew, Dityateva, Galina, Dityatev, Alexander   +29 more
core   +2 more sources

Occupancy of Agonist Drugs at the 5-HT1A Receptor [PDF]

Neuropsychopharmacology, 2003
Drugs acting on the 5-HT1A receptor are used in the treatment of depression, generalized anxiety disorder, and schizophrenia. This study investigated 5-HT1A receptor occupancy by the 5-HT1A agonist drugs flesinoxan (a highly selective probe for the 5-HT1A receptor) and ziprasidone (a novel atypical antipsychotic drug). Using a within-subject design, 14
R Alexander, Bantick, Eugenii A, Rabiner, Ella, Hirani, Michiel H, de Vries, Susan P, Hume, Paul M, Grasby   +5 more
openaire   +2 more sources

Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor

Journal of Pharmacological Sciences, 2010
Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects ...
Eun-Joo Shin, Wan Kyunn Whang, Sungun Kim, Jae-Hyung Bach, Jin-Man Kim, Xuan-Khanh Thi Nguyen, Thuy-Ty Lan Nguyen, Bae Dong Jung, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim   +10 more
doaj   +1 more source