Results 21 to 30 of about 79,681,589 (222)

The 5-HT1A receptor in Major Depressive Disorder [PDF]

European Neuropsychopharmacology, 2016
Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is associated with a high degree of morbidity and mortality. This debilitating disorder is currently one of the leading causes of disability nationwide and is predicted to be the leading cause of disease burden by the year 2030.
Joshua, Kaufman, Christine, DeLorenzo, Sunia, Choudhury, Ramin V, Parsey   +3 more
openaire   +2 more sources

Towards in vivo imaging of functionally active 5-HT1A receptors in schizophrenia: concepts and challenges

Translational Psychiatry, 2021
The serotonin 5-HT1A receptor has attracted wide attention as a target for treatment of psychiatric disorders. Although this receptor is important in the pharmacological mechanisms of action of new-generation antipsychotics, its characterization remains ...
Oriane Razakarivony, Adrian Newman-Tancredi, Luc Zimmer   +2 more
doaj   +1 more source

Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain

International Journal of Molecular Sciences, 2023
Neuropathic pain is a well-documented phenomenon in experimental and clinical diabetes; however, current treatment is unsatisfactory. Serotoninergic-containing neurons are key components of the descending autoinhibitory pathway, and a decrease in their activity may contribute at least in part to diabetic neuropathic pain (DNP).
Neha Munawar, Milad S. Bitar, Willias Masocha   +2 more
openaire   +2 more sources

Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists [PDF]

, 2014
Rett syndrome is a neurological disorder caused by loss of function of methyl-CpG-binding protein 2 (MeCP2). Reduced function of this ubiquitous transcriptional regulator has a devastating effect on the central nervous system.
Newman-Tancredi, Adrian, John M Bissonnette, Bissonnette, John, Ana P. Abdala, Ana Paula Abdala, John M. Bissonnette, Adrian eNewman-Tancredi, Adrian Newman-Tancredi, Abdala, Ana Paula   +8 more
core   +1 more source

1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands

, 2005
A series of new 1,2,4-benzothiadiazine derivatives with an arylpiperazine mojety linked at position 3 of the heterocyclic ringwere synthesized and assessed for their pharmacological profiles at a1-adrenoceptor subtypes (a1A, a1B and a1D) by functional ...
BRASILI L., LUPPI A, TAIT A, POGGESI E, MARUCCI, Gabriella, PREZIOSI E, FRANCHINI S, BUCCIONI, Michela, PARENTI C, LEONARDI A   +9 more
core   +3 more sources

Receptor–Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

Molecules, 2018
Due to the binding to a number of proteins to the receptor protomers in receptor heteromers in the brain, the term “heteroreceptor complexes” was introduced.
Dasiel O. Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fuxe   +14 more
doaj   +1 more source

Effects of bilateral sequential theta-burst stimulation on 5-HT1A receptors in the dorsolateral prefrontal cortex in treatment-resistant depression: a proof-of-concept trial

Translational Psychiatry, 2023
Theta-burst stimulation (TBS) represents a brain stimulation technique effective for treatment-resistant depression (TRD) as underlined by meta-analyses.
Matej Murgaš, Jakob Unterholzner, Peter Stöhrmann, Cécile Philippe, Godber M. Godbersen, Lukas Nics, Murray B. Reed, Chrysoula Vraka, Thomas Vanicek, Wolfgang Wadsak, Georg S. Kranz, Andreas Hahn, Markus Mitterhauser, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberger, Pia Baldinger-Melich   +16 more
doaj   +1 more source

Perospirone, a Novel Antipsychotic Drug, Inhibits Marble-Burying Behavior via 5-HT1A Receptor in Mice: Implications for Obsessive-Compulsive Disorder

Journal of Pharmacological Sciences, 2005
Perospirone is a novel atypical antipsychotic drug with dopamine (DA) D2- and serotonin (5-hydroxytryptamine, 5-HT) 5-HT2A-receptor antagonist, and 5-HT1A-receptor agonist properties.
Michihiko Matsushita, Nobuaki Egashira, Satoko Harada, Ryoko Okuno, Kenichi Mishima, Katsunori Iwasaki, Ryoji Nishimura, Michihiro Fujiwara   +7 more
doaj   +1 more source

Dual actions of 5‐MeO‐DIPT at the serotonin transporter and serotonin 5‐HT1A receptor in the mouse striatum and prefrontal cortex

Neuropsychopharmacology Reports, 2021
Aims 5‐Methoxy‐N,N‐diisopropyltryptamine (5‐MeO‐DIPT) is a synthetic orally active hallucinogenic tryptamine analogue. The present study examined whether the effects of 5‐MeO‐DIPT involve the serotonin transporter (SERT) and serotonin 5‐hydroxytryptamine‐
Yoko Hagino, Frank Scott Hall, George R. Uhl, Ichiro Sora, Kazutaka Ikeda   +4 more
doaj   +1 more source

Epigenetic Regulation of Resistance to Emotional Stress: Possible Involvement of 5-HT1A Receptor–Mediated Histone Acetylation

Journal of Pharmacological Sciences, 2014
.: The ability to resist stress is an important defensive function of a living body. Thus, elucidation of the mechanisms by which the brain resists stress could help to pave the way for new therapeutic strategies for stress-related psychiatric disorders ...
Minoru Tsuji, Kazuya Miyagawa, Hiroshi Takeda   +2 more
doaj   +1 more source