Results 21 to 30 of about 167,641 (233)

The 5-HT1A receptor in Major Depressive Disorder [PDF]

European Neuropsychopharmacology, 2016
Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is associated with a high degree of morbidity and mortality. This debilitating disorder is currently one of the leading causes of disability nationwide and is predicted to be the leading cause of disease burden by the year 2030.
Joshua, Kaufman, Christine, DeLorenzo, Sunia, Choudhury, Ramin V, Parsey   +3 more
openaire   +2 more sources

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]

, 2001
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Buwalda, Bauke, Vegt, Bea J. van der,, van der Vegt, BJ, Ruiter, Anne J.H. de,, Jong, Jelly G. de,, Koolhaas, J.M., de Ruiter, Anne J.H., Bauke Buwalda, Sietse F de Boer, Koolhaas, Jaap M.,, van der Vegt, Bea J., de Jong, Jelly G., Koolhaas, JM, de Boer, SF, de Jong, JG, Buwalda, Bauke,, Buwalda, B, Bea J van der Vegt, Boer, Sietse F. de,, Anne J.H de Ruiter, Jelly G de Jong, de Boer, Sietse F., Jaap M Koolhaas, de Ruiter, AJH   +23 more
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Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain

International Journal of Molecular Sciences, 2023
Neuropathic pain is a well-documented phenomenon in experimental and clinical diabetes; however, current treatment is unsatisfactory. Serotoninergic-containing neurons are key components of the descending autoinhibitory pathway, and a decrease in their activity may contribute at least in part to diabetic neuropathic pain (DNP).
Neha Munawar, Milad S. Bitar, Willias Masocha   +2 more
openaire   +2 more sources

Towards in vivo imaging of functionally active 5-HT1A receptors in schizophrenia: concepts and challenges

Translational Psychiatry, 2021
The serotonin 5-HT1A receptor has attracted wide attention as a target for treatment of psychiatric disorders. Although this receptor is important in the pharmacological mechanisms of action of new-generation antipsychotics, its characterization remains ...
Oriane Razakarivony, Adrian Newman-Tancredi, Luc Zimmer   +2 more
doaj   +1 more source

Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists [PDF]

, 2014
Rett syndrome is a neurological disorder caused by loss of function of methyl-CpG-binding protein 2 (MeCP2). Reduced function of this ubiquitous transcriptional regulator has a devastating effect on the central nervous system.
Newman-Tancredi, Adrian, John M Bissonnette, Bissonnette, John, Ana P. Abdala, Ana Paula Abdala, John M. Bissonnette, Adrian eNewman-Tancredi, Adrian Newman-Tancredi, Abdala, Ana Paula   +8 more
core   +1 more source

Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy

Frontiers in Neuroscience, 2010
Major depression is the most common form of mental illness, and is treated with antidepressant compounds that increase serotonin (5-HT) neurotransmission.
Paul R Albert, Brice Le François
doaj   +1 more source

Effects of bilateral sequential theta-burst stimulation on 5-HT1A receptors in the dorsolateral prefrontal cortex in treatment-resistant depression: a proof-of-concept trial

Translational Psychiatry, 2023
Theta-burst stimulation (TBS) represents a brain stimulation technique effective for treatment-resistant depression (TRD) as underlined by meta-analyses.
Matej Murgaš, Jakob Unterholzner, Peter Stöhrmann, Cécile Philippe, Godber M. Godbersen, Lukas Nics, Murray B. Reed, Chrysoula Vraka, Thomas Vanicek, Wolfgang Wadsak, Georg S. Kranz, Andreas Hahn, Markus Mitterhauser, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberger, Pia Baldinger-Melich   +16 more
doaj   +1 more source

The role of GABAB(1) receptor isoforms in anxiety and depression : genetic and pharmacological studies in the mouse [PDF]

, 2007
Anxiety and depression disorders represent common, serious and growing health problems world-wide. The neurobiological basis of anxiety and depression, however, remains poorly understood.
Jacobson, Laura Helen
core   +1 more source

Perospirone, a Novel Antipsychotic Drug, Inhibits Marble-Burying Behavior via 5-HT1A Receptor in Mice: Implications for Obsessive-Compulsive Disorder

Journal of Pharmacological Sciences, 2005
Perospirone is a novel atypical antipsychotic drug with dopamine (DA) D2- and serotonin (5-hydroxytryptamine, 5-HT) 5-HT2A-receptor antagonist, and 5-HT1A-receptor agonist properties.
Michihiko Matsushita, Nobuaki Egashira, Satoko Harada, Ryoko Okuno, Kenichi Mishima, Katsunori Iwasaki, Ryoji Nishimura, Michihiro Fujiwara   +7 more
doaj   +1 more source

Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain -- a combined in situ hybridisation/in vitro receptor autoradiographic study [PDF]

, 1991
The present study examined the comparative distribution of 5-HT1A receptor mRNA and 5-HT1A receptors in rat brain using a combination of in situ hybridisation histochemistry and in vitro receptor autoradiography. 5-HT1A mRNA was visualised using a 910 bp
Chalmers, Derek T., Watson, Stanley J.
core   +1 more source