Results 1 to 10 of about 714 (147)

Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy

Frontiers in Neuroscience, 2010
Major depression is the most common form of mental illness, and is treated with antidepressant compounds that increase serotonin (5-HT) neurotransmission.
Paul R Albert, Brice Le François, Albert Paul R   +2 more
exaly   +3 more sources

Pharmacological Studies on the Role of 5-HT1A Receptors in Male Sexual Behavior of Wildtype and Serotonin Transporter Knockout Rats

Frontiers in Behavioral Neuroscience, 2020
Brain serotonin (5-HT) neurotransmission plays an important role in male sexual behavior and it is well established that activating 5-HT1A receptors in rats facilitate ejaculatory behavior.
Sietse F De Boer, Berend Olivier, Jocelien D A Olivier   +2 more
exaly   +3 more sources

Expression of the serotonin 1A receptor in the horse brain

Journal of Animal Reproduction and Biotechnology, 2023
Background: Serotonin receptors can be divided into seven different families with various subtypes. The serotonin 1A (5-HT1A) receptor is one of the most abundant subtypes in animal brains.
Yeonju Choi, Minjung Yoon
doaj   +1 more source

5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability

iScience, 2023
Summary: Many psychiatric diseases have been associated with serotonin (5-HT) neuron dysfunction. The firing of 5-HT neurons is known to be under 5-HT1A receptor-mediated autoinhibition, but functional consequences of coexpressed receptors are unknown ...
Amina Benhadda, Célia Delhaye, Imane Moutkine, Xavier Marques, Marion Russeau, Corentin Le Magueresse, Anne Roumier, Sabine Lévi, Luc Maroteaux   +8 more
doaj   +1 more source

Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment

Frontiers in Pharmacology, 2022
The reduced antidepressant and antihyperalgesic effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine during maintenance treatment has been reported, but little is known about the molecular mechanism of this phenomenon.
Jiajia Dai, Jiajia Dai, Hyangin Kim, Zerong You, Michael F. McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Mao   +9 more
doaj   +1 more source

Associations Between a Polymorphism in the Rat 5-HT1A Receptor Gene Promoter Region (rs198585630) and Cognitive Alterations Induced by Microwave Exposure

Frontiers in Public Health, 2022
The nervous system is a sensitive target of electromagnetic radiation (EMR). Chronic microwave exposure can induce cognitive deficits, and 5-HT system is involved in this effect. Genetic polymorphisms lead to individual differences.
Haijuan Li, Yu Gao, Yong Zou, Simo Qiao, Weijia Zhi, Lizhen Ma, Xinping Xu, Xuelong Zhao, Junhua Zhang, Lifeng Wang, Xiangjun Hu   +10 more
doaj   +1 more source

Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease

Neurobiology of Disease, 2021
Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder that affects movement coordination leading to a premature death. Despite several efforts, no disease-modifying treatment is yet available for
Joana Pereira-Sousa, Bruna Ferreira-Lomba, Aina Bellver-Sanchis, Daniela Vilasboas-Campos, Jorge H. Fernandes, Marta D. Costa, Mark A. Varney, Adrian Newman-Tancredi, Patrícia Maciel, Andreia Teixeira-Castro   +9 more
doaj   +1 more source

Synthesis and Biological Evaluation of a Series of Novel 1-(3-((6-Fluoropyridin-3-yl)oxy)propyl)piperazines as Dopamine/Serotonin Receptor Agonists

Pharmaceutical Fronts, 2022
Evidence suggested that the use of partial dopamine D2/D3 receptor agonists may be a better choice for the treatment of Parkinson's disease (PD), and the stimulation of 5-HT1A receptors (mainly via nondopaminergic mechanisms) alleviates motor and ...
Xin-Li Du, Yan-Na Ni, Jiang-Rong Ji, Ze-Hong Wan, Zhi-Jing Hu, Yu-Qiang Ge, Jian-Qi Li, Guan Wang   +7 more
doaj   +1 more source

Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding. [PDF]

PLoS ONE, 2014
The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) may impact on the in-vivo binding of important serotonergic structures such as the serotonin transporter (5-HTT) and the serotonin-1A (5-HT1A) receptor.
Christoph Kraus, Pia Baldinger, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberger   +11 more
doaj   +1 more source

Functional characterization of cannabidiol effect on the serotonergic neurons of the dorsal raphe nucleus in rat brain slices

Frontiers in Pharmacology, 2022
Cannabidiol (CBD), the main non-psychoactive cannabinoid found in the cannabis plant, elicits several pharmacological effects via the 5-HT1A receptor. The dorsal raphe nucleus (DRN) is the main serotonergic cluster in the brain that expresses the 5-HT1A ...
Aitziber Mendiguren, Erik Aostri, Elena Alberdi, Alberto Pérez-Samartín, Joseba Pineda   +4 more
doaj   +1 more source