Results 101 to 110 of about 79,681,589 (222)

Estrogen regulation of the human 5-HT1A receptor gene [PDF]

open access: yes, 2004
Altered regulation of the 5-HT1A receptor is implicated in depression. Since depression is twice as prevalent in women versus men and major hormonal events in women trigger depression, I evaluated estrogen regulation of the 5-HT1A receptor in rat RN46A ...
Cockburn, Amanda M
core   +1 more source

Structural Determinants of 5-Ht1a Receptor Interaction With Gαi Subunits

open access: yes, 2011
The 5-hydroxytryptamine (5-HT) system modulates numerous physiological and behavioural processes, and dysfunction within this system underlies many behavioural disorders, such as major depression.
Zhou, Yi Yuan
core   +1 more source

Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system

open access: yesPLoS ONE, 2021
Cestodes are platyhelminth parasites with a wide range of hosts that cause neglected diseases. Neurotransmitter signaling is of critical importance for these parasites which lack circulatory, respiratory and digestive systems.
Federico Camicia   +9 more
doaj  

Fluoxetina y ciproheptadina- antagonismo en el receptor 5-HT1A

open access: yes, 2019
La consideración de los efectos clínicos de los agonistas y antagonistas en cada receptor destaca la función clínica. La ciproheptadina bloquea los efectos secundarios sexuales de los SSRI al antagonizar los receptores 5-HT2A, pero puede provocar una ...
Mercedes Guaia Memita Guaia
core   +1 more source

Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia

open access: yes, 2014
Previous studies have shown that depressed patients as well as animal models of depression exhibit decreased sensitivity to evoked pain stimuli, and serotonin is indicated to be involved in depression-induced hypoalgesia. The purpose of this study was to
Jiang, Zhao-Cai   +3 more
core  

5 HT1A receptor, an old target for new therapeutic agents

open access: yes, 2008
The serotonin receptor subtype 5-HT1A was one of the first serotonin receptor subtypes pharmacologically characterized. Over the last twenty years the 5-HT1A receptor has been the object of intense research efforts as witnessed by the 5-HT1A acting ...
LEOPOLDO, Marcello   +3 more
core  

5-HT1A autoreceptor modulation of locomotor activity induced by nitric oxide in the rat dorsal raphe nucleus

open access: yesBrazilian Journal of Medical and Biological Research, 2011
The dorsal raphe nucleus (DRN) is the origin of ascending serotonergic projections and is considered to be an important component of the brain circuit that mediates anxiety- and depression-related behaviors.
L.B. Gualda   +4 more
doaj   +2 more sources

The role of the 5-HT1a receptor in central cardiovascular regulation [PDF]

open access: yes, 1991
The aim of the studies describe~ in this thesis is to further clarify the role of the 5- HT1A receptor in central cardiovascular regulation. The hypotensive action of 5-HT1A receptor agonists is mainly due to differential sympatho-inhibition resulting ...
Dreteler, G.H.
core   +1 more source

Vortioxetine Dose-Dependently Reverses 5-HT Depletion-Induced Deficits in Spatial Working and Object Recognition Memorya Potential Role for 5-HT1A Receptor Agonism and 5-HT3 Receptor Antagonism

open access: yes, 2014
We previously reported that the investigational multimodal antidepressant, vortioxetine, reversed 5-HT depletion-induced memory deficits while escitalopram and duloxetine did not.
Jensen, Jesper Bornø   +3 more
core   +1 more source

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