Results 81 to 90 of about 79,681,589 (222)

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, Volume 183, Issue 23, Page 6865-6882, December 2026.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han, Jingxuan Xu, Yuntian Shen, Jitai Zhang, Xia Li, Xinlei Yao, Lei Qi, Hualin Sun   +7 more
wiley   +1 more source

A REVIEW ON FUNCTIONAL COMPARISON OF 5-HT1A AND 5-HT2C RECEPTORS [PDF]

, 2014
5-HT neurotransmission system is targeted by drugs useful in behavioural disorders, including anxiety, depression, psychosis and eating disorders. 5-HT1A autoreceptors, located on 5-HT neurones of the midbrain raphe nuclei, are coupled to K channels ...
Chaudhari, M A, Sapkale, P V, Patil, P R, Sarode, Surajj, Usman, Rageeb Md.   +4 more
core   +1 more source

Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist.

PLoS ONE, 2013
It has been suggested that drugs combining activities of selective serotonin reuptake inhibitor and 5-HT1A receptor agonist may form a novel strategy for higher therapeutic efficacy of antidepressant.
Hong-xia Chen, Zeng-liang Jin, Li-ming Zhang, Rui Xue, Xiao-dan Xu, Nan Zhao, Zhi-kun Qiu, Xian-wang Wang, You-zhi Zhang, Ri-fang Yang, Yun-feng Li   +10 more
doaj   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, Volume 59, Issue 11, Page 2375-2388, November 2026.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

Obsessive–Compulsive Disorder: Comorbidity, Biomarkers, Circuits, and Treatment Strategies

MedComm, Volume 7, Issue 11, November 2026.
OCD has a high comorbidity with other psychiatric conditions, among which anxiety is the most frequent one. The shared genetic biomarkers and common neural circuits underlying the co‐occurrence of OCD and anxiety pave a new path for understanding the pathogenic mechanism of OCD and suggest tailored and integrative treatment therapies for OCD from the ...
Xiao‐Yang Zhang, Zi‐Hao Li, Li‐Ping Shen, Bing‐Qing Kong, Qi‐Peng Zhang, Ya Ke, Juan Tu, Fei Wang, Wing‐Ho Yung, Jing‐Ning Zhu   +9 more
wiley   +1 more source

Time-course of recovery of 5-HT1A receptors and changes in 5-HT1A receptor mRNA after irreversible inactivation with EEDQ

Molecular Brain Research, 1996
In this study, the relationship between the expression of 5-HT1A receptors and level of receptor mRNA in discrete regions of rat brain was examined by inactivation of 5-HT1A receptors with the alkylating agent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ; i.p., 10 mg/kg) and measurement of the time-course of receptor recovery and changes in ...
R K, Raghupathi, D A, Brousseau, P, McGonigle   +2 more
openaire   +2 more sources

A Sensitive Approach for the Determination of the Novel Antidepressant Vilazodone: Electrochemical Sensing Using a Boron‐Doped Diamond Electrode in Surfactant‐Containing Media

ChemistryOpen, Volume 15, Issue 11, November 2026.
The combination of BRBS with Tween 20 enhanced the VLD oxidation signal at ~+0.67 V through surfactant‐assisted adsorption and preconcentration on the BDD electrode surface, resulting in improved sensitivity and signal‐to‐noise ratio. In this study, VLD was also found to undergo oxidation via the piperazine ring through a 2e−/2H+ process at the boron ...
Birdem Bersu İlvan, Ipek Kucuk, Selenay Sadak, Hülya Silah, Bengi Uslu   +4 more
wiley   +1 more source

GPR30 is necessary for estradiol-induced desensitization of 5- HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus [PDF]

, 2012
Estrogen therapy used in combination with selective serotonin reuptake inhibitor (SSRI) treatment improves SSRI efficacy for the treatment of mood disorders.
Li, Qian, McAllister, Carrie E., Creech, R. D., Kimball, R., Muma, Nancy A.   +4 more
core   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source