Results 91 to 100 of about 79,681,589 (222)

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Photoperiodic Regulation of SK Channels in Dorsal Raphe Serotonin Neurons

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Long summer‐like photoperiod reduces SK channel function in dorsal raphe serotonin neurons. SK channel blockade with apamin increases firing rate in slices from short‐photoperiod mice, mimicking the elevated firing seen in long‐photoperiod mice. Whole‐cell recordings show that apamin‐sensitive tail currents are smaller in long‐photoperiod neurons ...
Manuel A. Giannoni‐Guzmán, José C. Zepeda, Anna Kamitakahara, Valerie Magalong, Pat Levitt, Brad A. Grueter, Douglas G. McMahon   +6 more
wiley   +1 more source

Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression

, 1993
Using in situ hybridization techniques, the expression of 5-HT1A receptor mRNA was measured within the hippocampal formation after bilateral adrenalectomy (ADX).
SJ Watson, DT Chalmers, SP Kwak, H Akil, A Mansour   +4 more
core   +1 more source

Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides [PDF]

Journal of the Serbian Chemical Society
Serotonin, or 5-hydroxytryptamine (5-HT), is a biogenic amine most noted as a neurotransmitter, an activator of the utmost subtype family of G-protein- coupled receptors (GPCR). Drugs targeting 5-HT1A and other 5-HT receptors treat central nervous system
Andrić Deana B., Dukić-Stefanović Slađana, Krunić Mihajlo J., Jevtić Ivana I., Penjišević Jelena Z., Šukalović Vladimir B., Kostić-Rajačić Slađana   +6 more
doaj   +1 more source

Nature, nurture, and 5‐HT4R: Familial predisposition, not parental bonding, is associated with brain 5‐HT4R in a sex‐specific manner

Psychiatry and Clinical Neurosciences, Volume 80, Issue 11, Page 898-904, November 2026.
Background Major depressive disorder (MDD) aggregates in families. The neostriatum, key to reward and attachment circuits, has the highest density of serotonin 4 receptors (5‐HT4R). Striatal 5‐HT4R is low in MDD and linked to familial depression risk. Poor parental bonding increases depression risk, yet whether nature and nurture converge on 5‐HT4R is ...
Randi T. Kjær, Martin B. Jørgensen, Kristian H. R. Jensen   +2 more
wiley   +1 more source

Major Depressive Disorder With Non‐Suicidal Self‐Injury in Adolescents: Altered Morphological Inverse Divergence Gradient in Brain Structure and Gene Expression Patterns

Human Brain Mapping, Volume 47, Issue 15, October 15, 2026.
Using the morphometric inverse divergence gradient network (MIND‐Gd), this study shows that adolescents with major depressive disorder (MDD) and non‐suicidal self‐injury (NSSI) exhibit altered principal structural gradients relative to adolescents with MDD without NSSI, and that these gradient changes are spatially coupled to neurotransmitter receptor ...
Yan Zhang, Xinyuan Hu, Wei Wang, Jing Wang, Hongying Li, Yumei Wan, Jianlei Zhu, Fei Liu, Shiyue Tao, Duanwei Wang, Xiangtao Lin, Yingying Zhang, Hongmei Zhang, Yuandong Gong   +13 more
wiley   +1 more source

Effect of paroxetine and nefazodone on 5-HT1A receptor sensitivity.

, 2016
Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors.

core   +1 more source

Metaplastic Regulation of the Median Raphe Nucleus via Serotonin 5-HT1A Receptor on Hippocampal Synaptic Plasticity Is Associated With Gender-Specific Emotional Expression in Rats

Journal of Pharmacological Sciences, 2014
Gender differences in psychiatric disorders are considered to be associated with the serotonergic (5-HTergic) system; however the underlying mechanisms have not been clearly elucidated. In this study, possible involvement of the median raphe nucleus (MRN)
Sumitaka Inoue, Hiroki Shikanai, Machiko Matsumoto, Sachiko Hiraide, Yasuhiro Saito, Yoshiki Yanagawa, Mitsuhiro Yoshioka, Kei-ichi Shimamura, Hiroko Togashi   +8 more
doaj   +1 more source

ANTIDEPRESSANT-LIKE ACTIVITY OF NOVEL IMIDAZOLINE LIGANDS DIRECTED TO THE SEROTONIN 5-HT1A RECEPTOR

, 2016
For several years our studies have been focused on the design and preparation of biologically active ligands directed to different receptor systems and sharing a common scaffold characterized by an aromatic moiety (Ar) linked by a biatomic bridge (X) to ...
PIERGENTILI, Alessandro, Mannelli, Lorenzo Di Cesare, Micheli, Laura, GIORGIONI, Gianfabio, Ghelardini, Carla, GIANNELLA, Mario, QUAGLIA, Wilma, DEL BELLO, FABIO   +7 more
core   +1 more source

Receptor 5-HT1A i ISRS: Escurçament de la resposta antidepressiva [PDF]

, 2017
Els fàrmacs antidepressius necessiten unes quantes setmanes per aconseguir una resposta clínica (Trivedi et al., 2006). Una possible explicació és que l’augment de la concentració de serotonina (5-HT) extracel·lular produïda pels inhibidors de la ...
Oller Canet, Sílvia
core