Results 111 to 120 of about 167,641 (233)

Receptor 5-HT1A i ISRS: Escurçament de la resposta antidepressiva [PDF]

, 2017
Els fàrmacs antidepressius necessiten unes quantes setmanes per aconseguir una resposta clínica (Trivedi et al., 2006). Una possible explicació és que l’augment de la concentració de serotonina (5-HT) extracel·lular produïda pels inhibidors de la ...
Oller Canet, Sílvia
core  

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Addiction, Volume 121, Issue 6, Page 1541-1556, June 2026.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu, Chia‐Chun Hung, Marc N. Potenza, Kun‐Hsien Chou, Pei‐Lin Lee, Chu‐Chung Huang, Chiang‐Shan R. Li, Tony Szu‐Hsien Lee, Ching‐Po Lin   +8 more
wiley   +1 more source

Binding thermodynamics of 5-HT1A receptor ligands

, 1996
The thermodynamic parameters delta G degree, delta H degree and delta S degree of the binding equilibrium of 15 ligands (eight agonists and seven antagonists) to the 5-HT1A receptor subtype have been determined by affinity measurements carried out on rat
DALPIAZ, Alessandro, Stefania Gessi, Gastone Gilli, GESSI, Stefania, Alessandro Dalpiaz, BOREA, Pier Andrea, GILLI, Gastone, Pier Andrea Borea   +7 more
core   +1 more source

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

British Journal of Pharmacology, Volume 183, Issue 12, Page 3195-3212, June 2026.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini, Riccardo Camilotto, Michele Maritan, Erika Morrone, Stephen Afriyie Boateng, Anna Vacilotto, Salvatore Pacifico, Remo Guerrini, Nurulain T. Zaveri, Girolamo Calo'   +9 more
wiley   +1 more source

ANTIDEPRESSANT-LIKE ACTIVITY OF NOVEL IMIDAZOLINE LIGANDS DIRECTED TO THE SEROTONIN 5-HT1A RECEPTOR

, 2016
For several years our studies have been focused on the design and preparation of biologically active ligands directed to different receptor systems and sharing a common scaffold characterized by an aromatic moiety (Ar) linked by a biatomic bridge (X) to ...
PIERGENTILI, Alessandro, Mannelli, Lorenzo Di Cesare, Micheli, Laura, GIORGIONI, Gianfabio, Ghelardini, Carla, GIANNELLA, Mario, QUAGLIA, Wilma, DEL BELLO, FABIO   +7 more
core  

Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β. [PDF]

Int J Mol Sci, 2023
Harkin EF, Nasrallah G, Le François B, Albert PR.   +3 more
europepmc   +1 more source

5 HT1A receptor, an old target for new therapeutic agents

, 2008
The serotonin receptor subtype 5-HT1A was one of the first serotonin receptor subtypes pharmacologically characterized. Over the last twenty years the 5-HT1A receptor has been the object of intense research efforts as witnessed by the 5-HT1A acting ...
LEOPOLDO, Marcello, PERRONE R., BERARDI, Francesco, LACIVITA, ENZA   +3 more
core  

Development of fluorescent ligands for the human 5-HT1A receptor

, 2010
In this work, we report the design and synthesis of a set of fluorescent probes targeting the human 5-HT1A receptor (h5-HT1AR). Among the synthesized compounds, derivative 4 deserves special attention as being a high-affinity ligand (Ki = 2 nM) with good
Gamo, Ana M., Martín-Fontecha Corrales, María Del Mar, Viso, Alma, Ortega Gutiérrez, Silvia, Junquera González, María Elena, Benhamú Salama, Bellinda, Martínez Esperón, Maria F., Fernández de la Pradilla, Roberto, Alonso, Dulce, Aicart Sospedra, Emilio, Tortosa, Mariola, López Rodríguez, María Luz, Vázquez Villa, María Del Henar   +12 more
core   +1 more source

Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system

PLoS ONE, 2021
Cestodes are platyhelminth parasites with a wide range of hosts that cause neglected diseases. Neurotransmitter signaling is of critical importance for these parasites which lack circulatory, respiratory and digestive systems.
Federico Camicia, Hugo R. Vaca, Sang-Kyu Park, Augusto E. Bivona, Ariel Naidich, Matias Preza, Uriel Koziol, Ana M. Celentano, Jonathan S. Marchant, Mara C. Rosenzvit   +9 more
doaj  

Presynaptic 5-ht1a is related to 5-HTT receptor density in the human brain

, 2011
5-Hydroxytryptamine (5-HT or serotonin) is an important neurotransmitter for a number of brain functions and widely distributed throughout the brain. Physiological and pharmacological relationship between 5-HT1A receptors and serotonin transporter (5-HTT)
Mehta, Mitul A., Howes, Oliver D, Bose, Subrata K., Paul M Grasby, Bose, Subrata Kumer, Mitul A Mehta, Federico E Turkheimer, Turkheimer, Federico E; id_orcid, Turkheimer, Federico E., Sudhakar Selvaraj, Mehta, Mitul A; id_orcid, Hinz, Rainer, Rabiner, Eugenii A., Grasby, Paul M., Rainer Hinz, Eugenii A Rabiner, Subrata K Bose, Bose, Subrata K, Rabiner, Eugenii Alfredovich, Howes, Oliver D., Rabiner, Eugenii A, Mehta, Mitul, Venkatesha Murthy, Turkheimer, Federico E, Grasby, Paul M, Hinz, Rainer; id_orcid, Murthy, Venkatesh N, Oliver D Howes, Howes, Oliver, Selvaraj, Sudhakar, Murthy, Venkatesha   +30 more
core   +1 more source