Results 181 to 190 of about 79,681,589 (222)
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European Journal of Pharmacology, 1997
Twelve homing pigeons were trained to discriminate the 5-HT1A receptor agonist flesinoxan (0.25 mg/kg p.o.) from its vehicle in a fixed ratio (FR) 30 two-key operant drug discrimination procedure. Tests for generalization and antagonism showed that compounds with agonistic action at the 5-HT1A receptor, such as 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino ...
J, Mos +4 more
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Twelve homing pigeons were trained to discriminate the 5-HT1A receptor agonist flesinoxan (0.25 mg/kg p.o.) from its vehicle in a fixed ratio (FR) 30 two-key operant drug discrimination procedure. Tests for generalization and antagonism showed that compounds with agonistic action at the 5-HT1A receptor, such as 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino ...
J, Mos +4 more
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Neuroscience Letters, 1995
In this study, it has been clearly demonstrated that a selective 5-hydroxytryptamine (5-HT)1A agonist, 8-OH-2-(di-n-propylamino)-tetraline (8-OH-DPAT, 1 microM) significantly inhibited forskolin (10 microM)-stimulated cyclic AMP (cAMP) accumulation in the C6BU-1 cells transfected with 5-HT1A receptor gene.
K, Saitoh +5 more
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In this study, it has been clearly demonstrated that a selective 5-hydroxytryptamine (5-HT)1A agonist, 8-OH-2-(di-n-propylamino)-tetraline (8-OH-DPAT, 1 microM) significantly inhibited forskolin (10 microM)-stimulated cyclic AMP (cAMP) accumulation in the C6BU-1 cells transfected with 5-HT1A receptor gene.
K, Saitoh +5 more
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European Journal of Pharmacology, 2005
The pharmacological effect of the 5-HT1A receptor ligands, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), indorenate, and buspirone, alone or in combination with the antagonist MM-77, was studied in mice subjected to forced swimming. It was confirmed that this stressful factor produces an anxiolytic-like effect, which is reversed by the mentioned ...
Briones-Aranda, Alfredo, Picazo, Ofir
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The pharmacological effect of the 5-HT1A receptor ligands, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), indorenate, and buspirone, alone or in combination with the antagonist MM-77, was studied in mice subjected to forced swimming. It was confirmed that this stressful factor produces an anxiolytic-like effect, which is reversed by the mentioned ...
Briones-Aranda, Alfredo, Picazo, Ofir
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Journal of Pharmacological and Toxicological Methods, 1998
The functional activity of a series of 5-HT1A receptor ligands has been evaluated in a cell line expressing the human 5-HT1A receptor (h5-HT1A x CHO) using the agonist-stimulated increase in extracellular acidification rate, measured with the microphysiometer, as a functional assay.
J, Dunlop +3 more
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The functional activity of a series of 5-HT1A receptor ligands has been evaluated in a cell line expressing the human 5-HT1A receptor (h5-HT1A x CHO) using the agonist-stimulated increase in extracellular acidification rate, measured with the microphysiometer, as a functional assay.
J, Dunlop +3 more
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5-HT1A Receptors and Cardiovascular Control
1989Substantial evidence implicates 5-hydroxytryptamine (5-HT) neurones in the control of cardiovascular function. The precise nature of that role remains, however, undefined, a reflection in part of the plurality of 5-HT receptors and, in particular, the absence until recently of truly selective agonists and antagonists for these sites (Bradley et al ...
J. R. Fozard, A. K. Mir, A. G. Ramage
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Cerebrovascular and functional consequences of 5-HT1A receptor activation
Brain Research, 1991Cerebral glucose utilization and blood flow were measured in rats using 2-deoxy-D-[14C]glucose and [14C]iodoantipyrine quantitative autoradiography, respectively, following treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT).
D E, McBean +3 more
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The 5-HT1A Receptor: an unkept promise?
2000Stimulation of 5-HTIA receptors appears to be the most plausible basis for the anxiolytic effects of buspirone and has been hypothesized to explain effects of SSRIs in depression and panic disorder [1]. A surprising number of relatively selective agonists have been developed since the introduction of buspirone (Mead Johnson) in 1986 for anxiety ...
Louise R. Levine, William Z. Potter
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Effect of 5-HT1A receptor activation on hypothalamic glucose
Pharmacological Research, 2004The somatodendritic 5-HT1A agonist 8-OH-DPAT reduces serotonergic activity and stimulates feeding in freely feeding rats. Interactions between circulating glucose and 5-HT1A receptor expression related to feeding have been described. The aim of the present microdialysis study was to (1) describe the relation between feeding and glucose in the LH, (2 ...
J P, Voigt +4 more
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Differentiation of 5-HT1A receptor ligands by drug discrimination
European Journal of Pharmacology, 1997Pigeons were trained to discriminate 0.64 mg/kg (high dose) of 8-OH-DPAT (8-hydroxy-(2-di-n-propylamino)tetralin) from saline or were retrained to discriminate 0.16 mg/kg (low dose) of 8-OH-DPAT from saline. This resulted in a decrease of the ED50 for recognition of the 8-OH-DPAT cue from 0.14 to 0.04 mg/kg.
M C, Wolff, J D, Leander
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GABAA-5-HT1A receptor interaction in the mediobasal hypothalamus
Brain Research, 2004Both serotonin (5-HT) and gamma-aminobutyric acid (GABA) modulate female rat lordosis behavior and appear to interact in their control of the behavior. The current experiments were designed to investigate the interaction between these two neurotransmitters in sexually receptive female rats.
J, Guptarak, A, Selvamani, L, Uphouse
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