Results 201 to 210 of about 167,641 (233)

GABAA-5-HT1A receptor interaction in the mediobasal hypothalamus

Brain Research, 2004
Both serotonin (5-HT) and gamma-aminobutyric acid (GABA) modulate female rat lordosis behavior and appear to interact in their control of the behavior. The current experiments were designed to investigate the interaction between these two neurotransmitters in sexually receptive female rats.
J, Guptarak, A, Selvamani, L, Uphouse
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[The functional change in the 5-HT1A receptor induced by stress and the role of the 5-HT1A receptor in neuroprotection].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2005
Mice exposed to various stresses, especially restrained-stress, revealed the anxiogenic effect detected by the light-dark test. Under this condition, a remarkable decrease in [35S]GTPgammaS binding to membranes from the prefrontal cortex, amygdala and hypothalamus of restrained-stress mice stimulated by the selective 5-HT1A receptor agonist 5 ...
Minoru, Narita, Kazuya, Miyagawa, Michiko, Narita, Keisuke, Mizuo, Mayumi, Miyatake, Suzuki, Tsutomu   +5 more
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5-HT1A Receptors and Cardiovascular Control

1989
Substantial evidence implicates 5-hydroxytryptamine (5-HT) neurones in the control of cardiovascular function. The precise nature of that role remains, however, undefined, a reflection in part of the plurality of 5-HT receptors and, in particular, the absence until recently of truly selective agonists and antagonists for these sites (Bradley et al ...
J. R. Fozard, A. K. Mir, A. G. Ramage
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The therapeutic potential of 5-HT1A receptors: a patent review

Expert Opinion on Therapeutic Patents, 2012
The 5-HT(1A) receptors are implicated in mood disorders (anxiety, depression), in cognition, and in modulation of pain. Nearly 30 years of research in this field, there is still interest in developing new chemical entities capable of 5-HT(1A) receptor activation or blockade.This review article will highlight and review the research advances published ...
LACIVITA, ENZA, BERARDI, Francesco, PERRONE, Roberto, LEOPOLDO, Marcello, Di Pilato P, De Giorgio P, COLABUFO, Nicola Antonio   +6 more
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The 5-HT1A Receptor: an unkept promise?

2000
Stimulation of 5-HTIA receptors appears to be the most plausible basis for the anxiolytic effects of buspirone and has been hypothesized to explain effects of SSRIs in depression and panic disorder [1]. A surprising number of relatively selective agonists have been developed since the introduction of buspirone (Mead Johnson) in 1986 for anxiety ...
Louise R. Levine, William Z. Potter
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Pharmacology of polymorphic variants of the human 5-HT1A receptor

Biochemical Pharmacology, 2004
The 5-HT1A receptor is a critical mediator of serotonergic (5-HT) function. We have identified 13 potential single nucleotide polymorphisms resulting in amino acid changes throughout the human 5-HT1A receptor. The pharmacological profiles of these 13 polymorphic variants were then characterized using a high-throughput assay based on ligand-dependent ...
Andria L, Del Tredici, Hans H, Schiffer, Ethan S, Burstein, Jelveh, Lameh, Nina, Mohell, Uli, Hacksell, Mark R, Brann, David M, Weiner   +7 more
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Ontogeny of 5-HT1A receptor expression in the developing hippocampus

Developmental Brain Research, 2005
Serotonin (5-HT) has long been implicated in a number of neurodevelopmental processes including neuronal cell division, migration, neurite outgrowth, and synapse formation. However, relatively little is known about how these effects are mediated during normal brain development in vivo and the identity of the receptor subtypes involved in mediating ...
Tushar D, Patel, Feng C, Zhou
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[Presynaptic 5-HT1A receptors in immunomodulation].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2007
It is shown that a selective agonist of 5-HT1A receptors 8-OH-DPAT in a low dose (0.1 mg/kg), which is known to affect mainly the presynaptic 5-HT1A receptors increased the immune response at the peak of reactions (the forth or fifth day after immunization with sheep red blood cells - SRBC) in CBA mice and Wistar rats. Treatment of the animals with the
S M, Davydova, G V, Idova
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The 5-HT1A receptor and its ligands: structure and function

1999
An overview is presented on progress made in research on 5-HT1A receptors and their ligands since their discovery in 1983. Molecular biology has offered new tools, for example cloned 5-HT1A receptors, their mutants and chimeras to study structure and function.
Olivier, B., Soudijn, W., van Wijngaarden, I.   +2 more
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CBD and the 5-HT1A receptor: A medicinal and pharmacological review

Biochemical Pharmacology
Cannabidiol (CBD), a phytocannabinoid, has emerged as a promising candidate for addressing a wide array of symptoms. It has the ability to bind to multiple proteins and receptors, including 5-HT1AR, transient receptor potential vanilloid 1 (TRPV1), and cannabinoid receptors.
Claire Alexander, Jiyoon Jeon, Kyle Nickerson, Shayne Hassler, Maryam Vasefi   +4 more
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