Results 191 to 200 of about 167,641 (233)
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5-HT1A receptor-related anxiolytics
Trends in Pharmacological Sciences, 1987Abstract The brain serotonergic system has been implicated in the psychopathology of anxiety states and in the mechanism of action of the benzodiazepines downstream to the modulation of the GABA receptor/chloride channel complex. Jo¨rg Traber and Thomas Glaser report on the novel anti-anxiety agents buspirone, gepirone and ipsapirone which directly ...
Jo¨rg Traber, Thomas Glaser
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European Journal of Pharmacology, 1996
The effect of repeated treatment with imipramine on the 5-HT1A receptor-mediated inhibition of a population spike was studied in the rat CA1 hippocampal region ex vivo. Serotonin (5-hydroxytryptamine, 5-HT) and the selective 5-HT1A receptor agonist 8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) decreased dose-dependently the amplitude of population ...
M, Bijak +4 more
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The effect of repeated treatment with imipramine on the 5-HT1A receptor-mediated inhibition of a population spike was studied in the rat CA1 hippocampal region ex vivo. Serotonin (5-hydroxytryptamine, 5-HT) and the selective 5-HT1A receptor agonist 8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) decreased dose-dependently the amplitude of population ...
M, Bijak +4 more
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European Journal of Pharmacology, 1997
Twelve homing pigeons were trained to discriminate the 5-HT1A receptor agonist flesinoxan (0.25 mg/kg p.o.) from its vehicle in a fixed ratio (FR) 30 two-key operant drug discrimination procedure. Tests for generalization and antagonism showed that compounds with agonistic action at the 5-HT1A receptor, such as 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino ...
J, Mos +4 more
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Twelve homing pigeons were trained to discriminate the 5-HT1A receptor agonist flesinoxan (0.25 mg/kg p.o.) from its vehicle in a fixed ratio (FR) 30 two-key operant drug discrimination procedure. Tests for generalization and antagonism showed that compounds with agonistic action at the 5-HT1A receptor, such as 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino ...
J, Mos +4 more
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Neuroscience Letters, 1995
In this study, it has been clearly demonstrated that a selective 5-hydroxytryptamine (5-HT)1A agonist, 8-OH-2-(di-n-propylamino)-tetraline (8-OH-DPAT, 1 microM) significantly inhibited forskolin (10 microM)-stimulated cyclic AMP (cAMP) accumulation in the C6BU-1 cells transfected with 5-HT1A receptor gene.
K, Saitoh +5 more
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In this study, it has been clearly demonstrated that a selective 5-hydroxytryptamine (5-HT)1A agonist, 8-OH-2-(di-n-propylamino)-tetraline (8-OH-DPAT, 1 microM) significantly inhibited forskolin (10 microM)-stimulated cyclic AMP (cAMP) accumulation in the C6BU-1 cells transfected with 5-HT1A receptor gene.
K, Saitoh +5 more
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European Journal of Pharmacology, 2005
The pharmacological effect of the 5-HT1A receptor ligands, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), indorenate, and buspirone, alone or in combination with the antagonist MM-77, was studied in mice subjected to forced swimming. It was confirmed that this stressful factor produces an anxiolytic-like effect, which is reversed by the mentioned ...
Briones-Aranda, Alfredo, Picazo, Ofir
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The pharmacological effect of the 5-HT1A receptor ligands, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), indorenate, and buspirone, alone or in combination with the antagonist MM-77, was studied in mice subjected to forced swimming. It was confirmed that this stressful factor produces an anxiolytic-like effect, which is reversed by the mentioned ...
Briones-Aranda, Alfredo, Picazo, Ofir
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1997
Publisher Summary For 5-HT1A receptors, many potent and selective ligands belonging to different chemical classes such as aminotetralins, indolylalkylamines, ergolines, aporphines, arylpiperazines, and aryloxyalkylamines are available. The majority of these compounds are agonists or partial agonists.
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Publisher Summary For 5-HT1A receptors, many potent and selective ligands belonging to different chemical classes such as aminotetralins, indolylalkylamines, ergolines, aporphines, arylpiperazines, and aryloxyalkylamines are available. The majority of these compounds are agonists or partial agonists.
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Journal of Pharmacological and Toxicological Methods, 1998
The functional activity of a series of 5-HT1A receptor ligands has been evaluated in a cell line expressing the human 5-HT1A receptor (h5-HT1A x CHO) using the agonist-stimulated increase in extracellular acidification rate, measured with the microphysiometer, as a functional assay.
J, Dunlop +3 more
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The functional activity of a series of 5-HT1A receptor ligands has been evaluated in a cell line expressing the human 5-HT1A receptor (h5-HT1A x CHO) using the agonist-stimulated increase in extracellular acidification rate, measured with the microphysiometer, as a functional assay.
J, Dunlop +3 more
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Cerebrovascular and functional consequences of 5-HT1A receptor activation
Brain Research, 1991Cerebral glucose utilization and blood flow were measured in rats using 2-deoxy-D-[14C]glucose and [14C]iodoantipyrine quantitative autoradiography, respectively, following treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT).
D E, McBean +3 more
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Effect of 5-HT1A receptor activation on hypothalamic glucose
Pharmacological Research, 2004The somatodendritic 5-HT1A agonist 8-OH-DPAT reduces serotonergic activity and stimulates feeding in freely feeding rats. Interactions between circulating glucose and 5-HT1A receptor expression related to feeding have been described. The aim of the present microdialysis study was to (1) describe the relation between feeding and glucose in the LH, (2 ...
J P, Voigt +4 more
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Differentiation of 5-HT1A receptor ligands by drug discrimination
European Journal of Pharmacology, 1997Pigeons were trained to discriminate 0.64 mg/kg (high dose) of 8-OH-DPAT (8-hydroxy-(2-di-n-propylamino)tetralin) from saline or were retrained to discriminate 0.16 mg/kg (low dose) of 8-OH-DPAT from saline. This resulted in a decrease of the ED50 for recognition of the 8-OH-DPAT cue from 0.14 to 0.04 mg/kg.
M C, Wolff, J D, Leander
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