Results 181 to 190 of about 167,106 (231)

Antidepressant-like effects of psychedelics in a chronic despair mouse model: is the 5-HT_2A receptor the unique player? [PDF]

Neuropsychopharmacology
Sekssaoui M, Bockaert J, Marin P, Bécamel C.   +3 more
europepmc   +1 more source

5-HT_2A Receptor Knockout Mice Show Sex-Dependent Differences following Acute Noribogaine Administration. [PDF]

Int J Mol Sci
Villalba S, González B, Junge S, Bernardi A, González J, Fagúndez C, Torterolo P, Carrera I, Urbano FJ, Bisagno V.   +9 more
europepmc   +1 more source

Synthesis and <i>in vitro</i> evaluation of novel amino-phenylmethylene-imidazolone 5-HT_2A receptor antagonists. [PDF]

RSC Med Chem
Dwulet GE.
europepmc   +1 more source

Metabolism, Disposition, Excretion, and Potential Transporter Inhibition of 7-16, an Improving 5-HT_2A Receptor Antagonist and Inverse Agonist for Parkinson's Disease. [PDF]

Molecules
Hu Z, Wang W, Yang H, Zhao F, Sha C, Mi W, Yin S, Wang H, Tian J, Ye L.   +9 more
europepmc   +1 more source

A Complex Impact of Systemically Administered 5-HT2A Receptor Ligands on Conditioned Fear [PDF]

International Journal of Neuropsychopharmacology, 2021
Background: Though drugs binding to serotonergic 5-HT2A receptors have long been claimed to influence human anxiety, it remains unclear if this receptor subtype is best described as anxiety promoting or anxiety dampening.
Robert Pettersson, Jakob Näslund, Elias Eriksson   +2 more
exaly   +3 more sources

Activation of glucocorticoid receptors increases 5-HT2A receptor levels

Experimental Neurology, 2009
Major depression is associated with both dysregulation of the hypothalamic pituitary adrenal axis and serotonergic deficiency, not the least of the 5-HT2A receptor. However, how these phenomena are linked to each other, and whether a low 5-HT2A receptor level is a state or a trait marker of depression is unknown.
Trajkovska, Viktorija, Kirkegaard, Lisbeth, Krey, Gesa, Marcussen, Anders Bue, Thomsen, Morten Skøtt, Chourbaji, Sabine, Brandwein, Christiane, Ridder, Stephanie, Halldin, Christer, Gass, Peter, Knudsen, Gitte M, Aznar, Susana   +11 more
openaire   +4 more sources

“Selective” serotonin 5-HT2A receptor antagonists [PDF]

Biochemical Pharmacology, 2022
Blockade of the serotonin 5-HT2A G protein-coupled receptor (5-HT2AR) is a fundamental pharmacological characteristic of numerous antipsychotic medications, which are FDA-approved to treat schizophrenia, bipolar disorder, and as adjunctive therapies in major depressive disorder.
Austen B, Casey, Meng, Cui, Raymond G, Booth, Clinton E, Canal   +3 more
openaire   +3 more sources

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Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice

Biochemical and Biophysical Research Communications, 2006
Serotonin (5-hydroxytryptamine; 5-HT) 2A receptors contribute to the effects of 5-HT on platelet aggregation and vascular smooth muscle cell proliferation, and are reportedly involved in decreases in plasma levels of adiponectin, an adipokine, in diabetic subjects.
Katsunori Nonogaki
exaly   +3 more sources

Structure‐Based Identification of Aporphines with Selective 5‐HT2AReceptor‐Binding Activity

Chemical Biology and Drug Design, 2013
Selective blockade of the serotonin 5-HT2A receptor is a useful therapeutic approach for a number of disorders, including schizophrenia, insomnia and ischaemic heart disease.
Beow Keat Yap, Michael J C Buckle, Stephen W Doughty   +2 more
exaly   +2 more sources

The role of 5-HT2A receptors in antipsychotic activity

Life Sciences, 1995
The correlation between the clinical activity of antipsychotic agents and their affinity for the D2 dopamine receptor has been the mainstay of the hypothesis that schizophrenia is due to excessive dopaminergic function. More recently, the unique clinical profile of the atypical antipsychotic clozapine has been proposed to involve actions on additional ...
C J, Schmidt, S M, Sorensen, J H, Kehne, A A, Carr, M G, Palfreyman   +4 more
openaire   +2 more sources