Results 201 to 210 of about 167,106 (231)

Hallucinations and antipsychotics: The role of the 5-HT2A receptor

Behavioral and Brain Sciences, 2004
Behrendt & Young's (B&Y's) novel “unifying model” of hallucinations, although comprehensive, fails to incorporate research into the possible role of 5-HT2A receptors in the mode of action of novel “atypical” antipsychotic drugs (which treat hallucinations effectively), and into the role of such receptors, which are located in thalamocortical ...
Andrew James Goudie, Jonathan Charles Cole   +1 more
openaire   +1 more source

No Correlation between A(–1438)G Polymorphism in 5-HT2A Receptor Gene Promoter and the Density of Frontal Cortical 5-HT2A Receptors in Schizophrenia

Human Heredity, 1999
The A(–1438)G promoter polymorphism of the 5-hydroxytryptamine 2a receptor (5-HT2AR) gene and its influence on the cortical density of 5-HT2AR was studied using brain tissue donated at autopsy from 58 schizophrenic and 64 non-schizophrenic subjects.
A P, Kouzmenko, A, Scaffidi, A M, Pereira, W L, Hayes, D L, Copolov, B, Dean   +5 more
openaire   +2 more sources

A novel class of 5-HT2a receptor antagonists: Aryl aminoguanidines

Life Sciences, 1996
Local delivery of serotonin (5-HT) produces a rapid edematous response in soft tissues via increased fluid extravasation which is prevented by 5-HT2 antagonists such as ketanserin or mianserin. Here we report the effects of a new class of aminoguanidine 5-HT2 antagonists, with relative selectivity for 5-HT2A receptors which are potent inhibitors of 5 ...
H U, Bryant, D L, Nelson, D, Button, H W, Cole, M B, Baez, V L, Lucaites, D B, Wainscott, C, Whitesitt, J, Reel, R, Simon, G A, Koppel   +10 more
openaire   +2 more sources

Regulation of 5-HT2A Receptor at the Molecular Level

2000
The serotonin2A (5-HT2A) receptor belongs to the family of G-protein-coupled receptors. The number of available 5-HT2A receptors in the brain is influenced by several factors. 5-HT2A receptor shows a marked increase in number during perinatal and early postnatal development (Roth et al. 1991). Changes in the 5-HT2A-receptor-binding sites have also been
M. Toth, D. Benjamin
openaire   +1 more source

Role of Serotonin2A (5-HT2A) Receptors in Epilepsy

2018
5-Hydroxytryptamine 2A receptors (5-HT2ARs), have been implicated in various psychiatric and neurological disorders, including epilepsy. Interestingly, epileptic patients commonly present comorbid psychiatric symptoms, and a bidirectional link between depression and epilepsy has been suggested.
Vincenzo Crunelli, Marcello Venzi, Philippe De Deurwaerdère, Giuseppe Di Giovanni   +3 more
openaire   +1 more source

5-HT2A and mGlu2/3 receptor interactions

Behavioural Pharmacology, 2016
Serotonin [5-hydroxytryptamine (5-HT)] and glutamate have both been implicated in the pathophysiology of neuropsychiatric disorders but also in the mechanism of antipsychotic and hallucinogenic drug actions. Furthermore, close antagonistic interactions between 5-HT2A and metabotropic glutamate (mGlu)2/3 receptors have been established over the last ...
Lena, Wischhof, Michael, Koch
openaire   +2 more sources

Serotonergic Receptor 5-HT2A in the Cardiosympathovagal System

2018
The serotonin receptor 5-HT2A is widely expressed throughout the central nervous system. While abundant evidence exits implicating 5-HT2A receptors in regulating central nervous system, in particular stress responses and that their expression levels or signaling can contribute to stress-related disorders such as anxiety, depression and aggression; the ...
M. Kermorgant, A. Pavy-Le Traon, J. M. Senard, D. N. Arvanitis   +3 more
openaire   +1 more source

A study of the action of risperidone at 5-HT2A receptors

2016
VCU Theses and ...
openaire   +1 more source

5-HT2A Receptor

2010
Michael H. Bloch, Michael H. Bloch, Mark A. Geyer, David C. S. Roberts, Eileen M. Joyce, Jonathan P. Roiser, John H. Halpern, Joji Suzuki, Pedro E. Huertas, Torsten Passie, John H. Halpern, Joji Suzuki, Pedro E. Huertas, Torsten Passie, Joji Suzuki, Torsten Passie, Pedro E. Huertas, John H. Halpern, Joji Suzuki, Torsten Passie, Pedro E. Huertas, John H. Halpern, David E. Nichols, Marie-Louise G. Wadenberg, Trevor W. Robbins, David S. Baldwin, Sophie Tambour, John C. Crabbe, Lucio Tremolizzo, Gessica Sala, Carlo Ferrarese, Brian L. Odlaug, Jon E. Grant, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, Sarah Morgan, Angus Mackay, E. Ernst, Lawrence H. Price, Michael M. Morgan, MacDonald J. Christie, Susan Jones, Andrew Young, Elizabeth C. Warburton, Stephen J. Hill, Anthony R. Isles, Lawrence S. Wilkinson, Subhash C. Pandey, Subhash C. Pandey, Subhash C. Pandey, Aldo Badiani, James Winslow, Susan Jones, Jill B. Becker, Lucio Tremolizzo, Gessica Sala, Carlo Ferrarese, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, David E. Nichols, Jason C. G. Halford, Stephen B. Dunnett, Martine Cador, Naheed (Max) Mirza, Andrea Bari, Yesne Alici, William Breitbart, Andrea Bari, Becky Kinkead, Charles B. Nemeroff, Lucy C. Guillory, Jason C. G. Halford, Ennio Esposito, William Invernizzi, Gary Remington, Tomasz Schneider, Michel Billiard, Michel Billiard, Alyson J. Bond, Paolo Nencini, Michele S. Milella, Brian E. Leonard, Yesne Alici, William Breitbart, Luis de Lecea, Michel Billiard, Samuel B. Hutton, Jason C. G. Halford, R. H. De Rijk, E. R. de Kloet, Tooru M. Mizuno, Maria Isabel Colado, A. Richard Green   +94 more
openaire   +1 more source

Intact 5-HT2A receptor gene in schizophrenia

European Neuropsychopharmacology, 1996
K. Ohara, T. Ishigaki, D.-W. Xie, Y. Nakamura, K. Tani, K. Miyasato, K. Ohara   +6 more
openaire   +1 more source