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Differential Regulation of Human Serotonin Receptor Type 3A by Chanoclavine and Ergonovine
Molecules, 2021 Irritable bowel syndrome (IBS) is a chronic disease that causes abdominal pain and an imbalance of defecation patterns due to gastrointestinal dysfunction.
Sanung Eom +7 more
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Biomolecules, 2023 Serotonin (5-HT) plays an important role in the regulation of several basic functions of the central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT6) receptor has been an area of substantial research.
Ramakrishna Nirogi +9 more
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Molecular Pain, 2012 Background 5-hydroxytryptamine (5-HT) is one of the major neurotransmitters widely distributed in the CNS. Several 5-HT receptor subtypes have been identified in the spinal dorsal horn which act on both pre- and postsynaptic sites of excitatory and ...
Xie Du-Jie +6 more
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Journal of Pharmacological Sciences, 2009 We analyzed the expression of 5-HT2 receptors and proteins related to inactivation of 5-HT in primary cultures of mouse osteoblasts. The mRNA for the 5-HT2A receptor was detectable in anaplastic osteoblasts as well as in differentiated and matured ...
Takao Hirai +3 more
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Structural Pharmacology of Bufotenine Derivatives in Activating the 5-HT<sub>1A</sub> Receptor for Therapeutic Potential in Depression and Anxiety. [PDF]
Research (Wash D C)Li SJ +16 more
europepmc +2 more sources
Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies
BMC Neuroscience, 2006 Background The 5-HT3 receptor is a member of a neurotransmitter-gated ion channel family which includes nicotinic acetylcholine, GABAA, and glycine receptors.
Reeves David C, Lummis Sarah CR
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The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure. [PDF]
PLoS ONE, 2012 A positive inotropic responsiveness to serotonin, mediated by 5-HT(4) and 5-HT(2A) receptors, appears in the ventricle of rats with post-infarction congestive heart failure (HF) and pressure overload-induced hypertrophy.
Trond Brattelid +9 more
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5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability
iScience, 2023 Summary: Many psychiatric diseases have been associated with serotonin (5-HT) neuron dysfunction. The firing of 5-HT neurons is known to be under 5-HT1A receptor-mediated autoinhibition, but functional consequences of coexpressed receptors are unknown ...
Amina Benhadda +8 more
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Molecular and pharmacological characterization of serotonin 5-HT2α and 5-HT7 receptors in the salivary glands of the blowfly Calliphora vicina. [PDF]
PLoS ONE, 2012 Secretion in blowfly (Calliphora vicina) salivary glands is stimulated by the biogenic amine serotonin (5-hydroxytryptamine, 5-HT), which activates both inositol 1,4,5-trisphosphate (InsP(3))/Ca(2+) and cyclic adenosine 3',5'-monophosphate (cAMP ...
Claudia Röser +6 more
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Biomedicines, 2023 5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter of several nervous system functions. Its actions are complex, and depend on multiple factors, including the type of effector or receptor activated.
Abimael González-Hernández +3 more
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