Results 31 to 40 of about 284,594 (312)

The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure. [PDF]

PLoS ONE, 2012
A positive inotropic responsiveness to serotonin, mediated by 5-HT(4) and 5-HT(2A) receptors, appears in the ventricle of rats with post-infarction congestive heart failure (HF) and pressure overload-induced hypertrophy.
Trond Brattelid, Eirik Qvigstad, Lise R Moltzau, Silje V S Bekkevold, Dagny L Sandnes, Jon Arne K Birkeland, Tor Skomedal, Jan-Bjørn Osnes, Ivar Sjaastad, Finn Olav Levy   +9 more
doaj   +1 more source

The Constitutive Activity of Spinal 5-HT₆ Receptors Contributes to Diabetic Neuropathic Pain in Rats

Biomolecules, 2023
Diabetic neuropathy is often associated with chronic pain. Serotonin type 6 (5-HT6) receptor ligands, particularly inverse agonists, have strong analgesic potential and may be new candidates for treating diabetic neuropathic pain and associated co-morbid
Nazarine Mokhtar, Marcin Drop, Florian Jacquot, Sylvain Lamoine, Eric Chapuy, Laetitia Prival, Youssef Aissouni, Vittorio Canale, Frédéric Lamaty, Paweł Zajdel, Philippe Marin, Stéphane Doly, Christine Courteix   +12 more
doaj   +1 more source

Serotonin receptors: Subtypes, functional responses and therapeutic relevance [PDF]

, 1995
Recent, rapid progress in the molecular biology of serotonin (5-HT) receptors requires conceptual re-thinking with respect to receptor classification.
Saxena, P.R. (Pramod Ranjan)
core   +1 more source

Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms

Biomedicines, 2023
5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter of several nervous system functions. Its actions are complex, and depend on multiple factors, including the type of effector or receptor activated.
Abimael González-Hernández, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink, Carlos M. Villalón   +3 more
doaj   +1 more source

Both exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro

Frontiers in Neuroscience, 2014
The roles of 5-HT3 and 5-HT4 receptors in the modulation of intestinal propulsion by luminal application of 5-HT and augmentation of endogenous 5-HT effects were studied in segments of guinea-pig ileum in vitro. Persistent propulsive contractions evoked
Rachel M Gwynne, Amanda J Clarke, John B Furness, Joel C Bornstein   +3 more
doaj   +1 more source

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
A McQuillin, A Scimemi, AA Boucher, AD Michel, AJ Law, AM Basso, AN Guerra, AV Gourine, B Sperlagh, B Sperlagh, B Sperlagh, Beáta Sperlágh, BP Guiard, C Csolle, C Delarasse, C Lavebratt, C Toro, C Verderio, Cecilia Csölle, CG Thomas, CM Anderson, DS Hasin, DT Balu, E Castren, E Fuchs, E Mundo, E Shimizu, E. Sylvester Vizi, Edit Papp, EJ Nestler, EK Green, F Frenois, F Karege, Flóra Gölöncsér, G Nagy, G Nowak, G Sanacora, G Sanacora, G Sanacora, Gabriella Zsilla, GE Hardingham, GE Wood, JE Malberg, JF Cryan, JF Cryan, JH Meador-Woodruff, JL Warner-Schmidt, JM Boyce-Rustay, JM Krueger, JO Groves, JS Barnholtz, K Hashimoto, K Hejjas, K Martinowich, K Viwatpinyo, K Wager-Smith, KR Tovar, L Backlund, L Bocchio-Chiavetto, L Papp, L Papp, L Patti, L Santarelli, L Stokes, L Zhang, LM Monteggia, M Baranyi, M Barbera-Cremades, M Diaz-Hernandez, M Grigoroiu-Serbanescu, M Koehl, M Masin, M Solle, ME Kozisek, ME Kozisek, ME Szapacs, ML Barbaccia, MT Miras-Portugal, MW Pfaffl, Mária Baranyi, N Barden, N Drigues, O Berton, OH Lowry, P Fossati, P Skolnick, P Soronen, P Vanhoutte, PA Lapchak, Peter Illes, R Dantzer, RC Hogg, RJ Griffiths, RJ Rodrigues, RS Duman, S Alloisio, S Duan, S Lucae, S Monleon, S Schnydrig, SN Williams, SP Banerjee, T Balazsa, T Deltheil, T Deltheil, T Zigova, Thierry Amédée, V Shukla, VF Labrousse, VM Brautigam, W Peng, Y Dwivedi, Y Shirayama, Z Hracskó, Ágnes Kittel   +114 more
core   +2 more sources

Central serotonin2C receptor : from physiology to pathology [PDF]

, 2006
Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions ...
Benigno, Arcangelo, Di Giovanni, Giuseppe, Esposito, Ennio, Matteo, Vincenzo di, Pierucci, Massimo   +4 more
core   +1 more source

Changes in 5-HT Receptor Expression in Untreated, de novo Patients with Parkinson's Disease

Journal of Parkinson’s Disease, 2014
Background: Serotonin (5-HT) has long been implied in the pathophysiology of Parkinson's disease (PD). In addition, the 5-HT 2A receptor is associated with the regulation of motor function and mood.
Maartje Melse, Sonny K.H. Tan, Yasin Temel, Marinus J.P.G. van Kroonenburgh, Albert F.G. Leentjens   +4 more
doaj   +1 more source

Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease [PDF]

, 2008
We studied the hypothesis that disturbances in 5-HT_{6} receptor function in the temporal cortex may contribute to clinical symptoms of Alzheimer's disease (AD).
Chen, C.P. (Christopher P.), Chuang, T.T. (Tsu T.), Francis, P.T. (Paul T.), Garcia-Alloza, M. (Mónica), Gil-Bea, F.J. (Francisco J.), Lai, M.K. (Mitchell K.), Marcos, B. (Beatriz), Ramirez, M.J. (María Javier), Tsang, S.W.T.Y. (Shirley W.T.Y.)   +8 more
core   +1 more source

Dynamics and Patterning of 5-Hydroxytryptamine 2 Subtype Receptors in JC Polyomavirus Entry

Viruses, 2022
The organization and dynamics of plasma membrane receptors are a critical link in virus-receptor interactions, which finetune signaling efficiency and determine cellular responses during infection. Characterizing the mechanisms responsible for the active
Kashif Mehmood, Michael P. Wilczek, Jeanne K. DuShane, Matthew T. Parent, Colleen L. Mayberry, Jaqulin N. Wallace, Francois L. Levasseur, Tristan M. Fong, Samuel T. Hess, Melissa S. Maginnis   +9 more
doaj   +1 more source