Results 51 to 60 of about 125,938 (267)

Serotonin receptor‐mediated vasorelaxation occurs primarily through 5‐HT4 activation in bovine lateral saphenous vein

Physiological Reports
To better understand mechanisms of serotonin‐ (5‐HT) mediated vasorelaxation, isolated lateral saphenous veins from cattle were assessed for vasoactivity using myography in response to increasing concentrations of 5‐HT or selective 5‐HT receptor agonists.
Ronald J. Trotta, David L. Harmon, James L. Klotz   +2 more
doaj   +1 more source

Failure of Repeated Electroconvulsive Shock Treatment on 5-HT4-Receptor-Mediated Depolarization Due To Protein Kinase A System in Young Rat Hippocampal CA1 Neurons

Journal of Pharmacological Sciences, 2004
We previously demonstrated that repeated electroconvulsive shock (ECS) treatment enhanced serotonin (5-HT)1A- and 5-HT3-receptor-mediated responses in hippocampal CA1 pyramidal neurons.
Kumatoshi Ishihara, Masashi Sasa
doaj   +1 more source

Upregulation of 5-hydroxytryptamine receptor signaling in coronary arteries after organ culture. [PDF]

PLoS ONE, 2014
5-Hydroxytryptamine (5-HT) is a powerful constrictor of coronary arteries and is considered to be involved in the pathophysiological mechanisms of coronary-artery spasm. However, the mechanism of enhancement of coronary-artery constriction to 5-HT during
Chun-Yu Deng, Hui Yang, Su-Juan Kuang, Fang Rao, Yu-Mei Xue, Zhi-Ling Zhou, Xiao-Ying Liu, Zhi-Xin Shan, Xiao-Hong Li, Qiu-Xiong Lin, Shu-Lin Wu, Xi-Yong Yu   +11 more
doaj   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12.

PLoS ONE, 2011
In addition to its role as neurotransmitter, serotonin (5-HT) is an important modulator of inflammation and immunity. Here, we report novel findings suggesting a 5-HT involvement in T cell migration.
Elena Magrini, Ildikò Szabò, Andrea Doni, Javier Cibella, Antonella Viola   +4 more
doaj   +1 more source

Involvement of the Spinal Serotonergic System in the Analgesic Effect of [6]-Shogaol in Oxaliplatin-Induced Neuropathic Pain in Mice

Pharmaceuticals, 2023
Oxaliplatin is a chemotherapy drug that can induce severe acute neuropathy in patients within hours of treatment. In our previous study, 10 mg/kg [6]-shogaol (i.p.) significantly alleviated cold and mechanical allodynia induced by a 6 mg/kg oxaliplatin ...
Juan Gang, Keun-Tae Park, Suyong Kim, Woojin Kim   +3 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Reduction in Hindquarter Vascular Resistance Supports 5-HT7 Receptor Mediated Hypotension

Frontiers in Physiology, 2021
The 5-HT7 receptor is the primary mediator of both the acute (<hours) and chronic (day-week) decreases in mean arterial pressure (MAP) during low dose 5-HT infusion in rats.
Bridget M. Seitz, Stephanie W. Watts, Gregory D. Fink   +2 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Pharmacological characterization of a 5-HT1-type serotonin receptor in the red flour beetle, Tribolium castaneum.

PLoS ONE, 2013
Serotonin (5-hydroxytryptamine, 5-HT) is known for its key role in modulating diverse physiological processes and behaviors by binding various 5-HT receptors.
Rut Vleugels, Cynthia Lenaerts, Arnd Baumann, Jozef Vanden Broeck, Heleen Verlinden   +4 more
doaj   +1 more source