Results 201 to 210 of about 87,483 (259)
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Molecular Neuroanatomy of 5-HT Receptors
1991Serotoninergic terminals are found throughout the brain, suggesting an involvement of 5-HT in many brain functions. The effects of 5-HT on a given neuron are dependent on the different types of receptors expressed by this neuron, their location on the neuron and the signal transduction mechanism used. In order to provide information on the localization
PALACIOS J. M +3 more
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5-HT antagonists and blockade of neuronal (5-HT) receptors on ganglion cells
General Pharmacology: The Vascular System, 1984Potential changes in superior cervical ganglion cells evoked by 5-HT or the nicotinic agonist, dimethyl-phenyl piperazinium (DMPP), were recorded using the sucrose-gap method and a number of putative 5-HT antagonists tested for potency and selectivity. Selective blockade of 5-HT responses was produced by 5-HT itself and, in increasing order of potency,
H L, Nash, D I, Wallis, G, Ash
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Heart 5-HT Receptors. A Novel 5-HT Receptor in Human Atrium
1990Receptors for 5-hydroxytryptamine (5-HT) on myocardial cells differ among species and even among different heart regions of the same species. In molluscs 5-HT enhances heart force and cyclic AMP, and lysergic acid diethylamide (LSD) is a potent agonist. In human atria 5-HT, but not LSD, increases contractile force through unknown receptors (not blocked
Alberto J. Kaumann +5 more
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Molecular biology of 5-HT receptors
Trends in Pharmacological Sciences, 1989Within the past six months, isolation of cDNA or genomic clones has been reported for three 5-HT receptors, the 5-HT1C, 5-HT1A and 5-HT2 subtypes. As members of the G protein receptor superfamily, all three 5-HT receptor clones encode single-subunit proteins containing approximately 450 amino acids arrayed as seven interconnected transmembrane segments.
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The behavioural response to 5-HT receptor agonists and subtypes of the central 5-HT receptor
Trends in Pharmacological Sciences, 1985Abstract The analysis of the role of 5-hydroxytryptamine (5-HT)-containing neurons in the control of behaviour is complicated by the diverse functional effects that may follow the activation of the multiple types of recognition site for 5-HT that have recently been identified in the CNS, and the lack of specificity inherent in many of the 5-HT ...
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Discriminating between 5-HT₃A and 5-HT₃AB receptors.
British journal of pharmacology, 2014The 5-HT3B subunit was first cloned in 1999, and co-expression with the 5-HT3A subunit results in heteromeric 5-HT₃AB receptors that are functionally distinct from homomeric 5-HT₃A receptors. The affinities of competitive ligands at the two receptor subtypes are usually similar, but those of non-competitive antagonists that bind in the pore often ...
A J, Thompson, S C R, Lummis
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MDP and 5-HT receptors. Does MDP interact with 5-HT(7) receptors?
International journal of immunopharmacology, 2000A possible interaction of immunomodulator muramyl dipeptide (MDP) with 5-HT(7) (5-hydroxytryptamine) receptors was investigated. The activation of 5-HT(7) receptors relaxes the guinea-pig distal ileum. The whole ileum segments were, therefore, cut and placed into the bath.
J, Sevcík +3 more
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1990
Migraine is a vascular headache but its pathophysiology is complex and multifactorial. Of the many pathophysiological factors that are implicated in migraine, changes in the metabolism of 5-hydroxytryptamine (5-HT) are the best documented. During the headache phase of migraine, urinary excretion of 5-hydroxyindoleacetic acid increases, whereas the ...
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Migraine is a vascular headache but its pathophysiology is complex and multifactorial. Of the many pathophysiological factors that are implicated in migraine, changes in the metabolism of 5-hydroxytryptamine (5-HT) are the best documented. During the headache phase of migraine, urinary excretion of 5-hydroxyindoleacetic acid increases, whereas the ...
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Electrophysiology of 5-HT Receptors
2000Within the past decade, molecular cloning techniques have confirmed that 5-hydroxytryptamine (5-HT) receptor subtypes, originally predicted from radioligand binding and functional studies (e.g., 5-HT1, 5-HT2, 5-HT3, 5-HT4), represent separate and distinct gene products. This knowledge has had a crucial impact on electrophysiological approaches to the 5-
G. K. Aghajanian, R. Andrade
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