Results 221 to 230 of about 12,268,158 (295)

Evaluating the Therapeutic Potential of Common Sage (<i>Salvia officinalis</i> L.): Antioxidant Capacity, Cytotoxicity and Dose-Dependent Effects on Gastric Smooth Muscle Viability and Function. [PDF]

Molecules
Zaytseva E, Ardasheva R, Prissadova N, Yotov V, Slavova I, Tomova T, Dyankov S, Argirova M, Krastev A.   +8 more
europepmc   +1 more source

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

Psycho-cardiovascular interaction network in cardiovascular health and disease: signaling pathways and molecular mechanisms. [PDF]

Precis Clin Med
Li Z, Li F, Yan C, Xiang L, Gong A, Cao Y, Zhou Y, Zhang W, Zeng R.   +8 more
europepmc   +1 more source

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Adjunctive Pharmacotherapy for Major Depressive Disorder with Anxiety Symptoms: from Monoamines to Recent Clinical Evidence. [PDF]

CNS Drugs
McIntyre RS, Kato M, Thase ME, Therrien F, Marrache AM, Ikehara K, Ardic F, Boucher M.   +7 more
europepmc   +1 more source

Modulating Local Coordination in Single‐Atom Catalysts: From Fundamental Concepts to Emerging Breakthroughs in Electrocatalysis

Angewandte Chemie, EarlyView.
This review summarizes atomic‐level design strategies for single‐atom catalysts, emphasizing modulation of the local coordination environment, active‐site geometry, and metal‐support interactions to optimize catalytic activity and stability in electrocatalytic energy conversion applications.
Ashwani Kumar, Harun Tüysüz
wiley   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones. [PDF]

J Physiol
Wu Y, Bravo E, Richerson GB.
europepmc   +1 more source

Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-<i>N</i>-methyl-<i>N</i>-isopropyltryptamine and Related Analogs. [PDF]

ACS Chem Neurosci
Glatfelter GC, Schalk SS, Walther D, Maitland AD, Gonzalez NR, Partilla JS, Anas NA, Chadeayne AR, Naeem M, Manke DR, McCorvy JD, Baumann MH.   +11 more
europepmc   +1 more source

Lateral Habenula 5-HT₂A Receptors Mediate Social Deficits in a Valproic Acid-Induced Rodent Model of Autism Spectrum Disorder. [PDF]

Mol Neurobiol
Zhang C, Sang H, Zhang B, Zhao Z, Shang H, Wang X, Luan S, Wang J.   +7 more
europepmc   +1 more source

Serotonin in Cardiovascular Disease: From Pathophysiological Insights to Clinical Utility. [PDF]

Diagnostics (Basel)
Veliz Perez A, Badea M, Gaman EL.
europepmc   +1 more source