Results 251 to 260 of about 199,847 (309)
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Molecular Neuroanatomy of 5-HT Receptors
1991Serotoninergic terminals are found throughout the brain, suggesting an involvement of 5-HT in many brain functions. The effects of 5-HT on a given neuron are dependent on the different types of receptors expressed by this neuron, their location on the neuron and the signal transduction mechanism used. In order to provide information on the localization
PALACIOS J. M +3 more
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Heart 5-HT Receptors. A Novel 5-HT Receptor in Human Atrium
1990Receptors for 5-hydroxytryptamine (5-HT) on myocardial cells differ among species and even among different heart regions of the same species. In molluscs 5-HT enhances heart force and cyclic AMP, and lysergic acid diethylamide (LSD) is a potent agonist. In human atria 5-HT, but not LSD, increases contractile force through unknown receptors (not blocked
Alberto J. Kaumann +5 more
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5-Hydroxytryptamine (5-HT) Receptor Ligands
Current Pharmaceutical Design, 2007Serotonin (5-HT) receptors are part of the G protein-coupled and ligand-gated ion channel families. 5-HT exerts its diverse actions by binding to cell surface receptors which can be classified into seven distinct families (5-HT1 to 5-HT7) according to their structural diversity and mode of action.
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Molecular biology of serotonin (5-HT) receptors
Pharmacology Biochemistry and Behavior, 1991The recent cloning of three types of 5-hydroxytryptamine (5-HT, serotonin) receptors substantiates radioligand-based definitions of 5-HT receptors, and provides a framework in which to understand the function and evolution of the receptors. The primary sequences determined by molecular cloning of the 5-HT1c, 5-HT1a and 5-HT2 receptors place each of ...
J C, Shih, W, Yang, K, Chen, T, Gallaher
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5-HT Receptors: Subtypes and Second Messengers
Journal of Receptor Research, 1991Our knowledge about 5-HT (serotonin, 5-hydroxytryptamine) receptors has gained significantly over the recent few years. The discovery of selective ligands and the use of new techniques have led to a significant increase in the number of recognised receptors subtypes.
D, Hoyer, P, Schoeffter
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Modern 5-HT receptor classification and 5-HT based drugs
Expert Opinion on Investigational Drugs, 1994Based on operational (agonist and antagonist rank order), transductional (second messenger coupling) and structural (gene and amino acid sequence) criteria, the Nomenclature Committee of the Serotonin Club has discerned four distinct 5-HT receptor types, besides two less well characterised categories including some recombinant and the so-called ‘orphan’
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Electrophysiology of 5-HT Receptors
2000Within the past decade, molecular cloning techniques have confirmed that 5-hydroxytryptamine (5-HT) receptor subtypes, originally predicted from radioligand binding and functional studies (e.g., 5-HT1, 5-HT2, 5-HT3, 5-HT4), represent separate and distinct gene products. This knowledge has had a crucial impact on electrophysiological approaches to the 5-
G. K. Aghajanian, R. Andrade
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Translating 5-HT receptor pharmacology.
Neurogastroenterology and motility, 2010Since metoclopramide was first described (in 1964) there have been several attempts to develop compounds which retained gastrointestinal prokinetic activity (via 5-HT(4) receptor activation) but without the limiting side effects associated with dopamine D(2) receptor antagonism.
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MDP and 5-HT receptors. Does MDP interact with 5-HT(7) receptors?
International journal of immunopharmacology, 2000A possible interaction of immunomodulator muramyl dipeptide (MDP) with 5-HT(7) (5-hydroxytryptamine) receptors was investigated. The activation of 5-HT(7) receptors relaxes the guinea-pig distal ileum. The whole ileum segments were, therefore, cut and placed into the bath.
J, Sevcík +3 more
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Neuronal 5-HT receptors in the periphery
Neuropharmacology, 19845-Hydroxytryptamine (5-HT) induces responses in neurones from all branches of the mammalian peripheral nervous system. Responses may be excitatory or inhibitory and are mediated through at least four distinct receptor sites. One receptor mediates excitation in motoneurones and preganglionic sympathetic neurones and can be designated a D (or possibly 5 ...
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