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Regional 5-hydroxyindoleacetic acid production in humans

Life Sciences, 1995
Veno-arterial plasma concentration differences and regional organ plasma flows were used to quantify the relative amounts of 5-hydroxyindoleacetic acid (5-HIAA) contributed by various sites into the peripheral circulation. Positive venoarterial concentration gradients were found in the hepatosplanchnic, forearm, cardiac and jugular vessels in the ...
Helen Cox   +6 more
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Origin of 5-Hydroxyindoleacetic Acid in the Spinal Fluid

Science, 1971
5-Hydroxyindoleacetic acid applied intracisternally in cats does not appear in spinal fluid. Changes of 5-hydroxyindoleacetic acid concentration in the spinal cord are clearly reflected in the perfusate of the spinal subarachnoid space. Thus, 5-hydroxyindoleacetic acid in the spinal fluid originates from the spinal cord and reflects metabolic changes ...
B. Živković, M. Bulat
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5‐HYDROXYINDOLEACETIC ACID IN CHILDREN WITH DOWN'S SYNDROME

Acta Paediatrica, 1973
SummaryThe present study has demonstrated the existence of a defect in the metabolism of serotonin in CNS in Down's syndrome. The nature of this defect is sofar unknown.
B.‐E. Roos   +3 more
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5‐HYDROXYINDOLEACETIC ACID IN CEREBROSPINAL FLUID OF HYDROCEPHALIC CHILDREN

Acta Paediatrica, 1969
SummaryThere was a significant increase in the level of 5‐HIAA in lumbar CSF of children with hydrocephalus compared with “non‐hydroce‐phalic” children. In “non‐hydrocephalic” children the values of 5‐HIAA were found to be highest in the newborn successively decreasing to the levels of adult persons at the age of about one year.
H. Andersson, B.-E. Roos
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Colorimetric and Spectrophotometric Titration of 5-Hydroxyindoleacetic Acid

Experientia, 1955
Vengono descritti due metodi, colorimetrico l'uno e spettrofotometrico l'altro, atti alla titolazione quantitativa dell'acido 5-idrossiindolilacetico in soluzioni pure o in eluati, da cromatogrammi su carta, di macchie costituite da acido 5-idrossiindolilacetico.
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Indomethacin therapy and the measurement of urinary 5-hydroxyindoleacetic acid

Clinica Chimica Acta, 1982
Indomethacin was first introduced in 1963 for treatment of rheumatoid arthritis. About half the single oral dose is 0-demethylated and 10% is conjugated to glucuronic acid by an hepatic microsomal system, and lo-20% is excreted unchanged in the urine; a portion is N-deacylated by non-microsomal systems [I].
William J. Riley   +2 more
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5-Hydroxyindoleacetic Acid in the Spinal Cord and Spinal Fluid

Pharmacology, 1971
After i.v. or spinal subarachnoid application of 5-hydroxytryptamine (5-HT) in cat an increase of 5-HT, followed by augmentation of 5-hydroxyindoleacetic acid (5-HIAA), in the spinal cordis observed.
zivković B, Bulat M
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Excretion of 5-hydroxyindoleacetic Acid in Patients Irradiated Therapeutically

International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1973
SummaryThe 24-hour urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) was determined in patients suffering from genital carcinoma who had been irradiated therapeutically with gamma-rays from intracavitary radium sources and/or with X-rays. Radium was applied for 46 hours, twice within two weeks.
Z Deanović, D Pericić
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Methadone increases Mouse Brain 5-Hydroxyindoleacetic Acid

Nature, 1971
METHADONE, a synthetic narcotic with many similarities to morphine, is currently being used extensively as a crucial part of treatment-rehabilitation programmes for heroin addiction. In the doses used for “methadone maintenance”, this compound has minor tranquillizing effects, blocks the euphoric effects of heroin, eliminates drug craving, and prevents
Herbert D. Kleber, Malcolm B. Bowers
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