Results 61 to 70 of about 6,863 (169)

Metabolic Fingerprints of High‐Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation

Analysis &Sensing, Volume 6, Issue 4, July 2026.
This study presents a multimatrix untargeted metabolomics analysis of fecal, plasma, and urine samples from individuals at high risk for pancreatic cancer development. Integrated multivariate and cofactor‐adjusted models were applied to characterize cross‐matrix metabolomic associations, incorporating pancreatic magnetic resonance imaging data, sex ...
Vladyslav Dovhalyuk, Quang‐Dong Bui, Vincent Ripoll, Wiktor Rutkowski, Miroslav Vujasinovic, J.‐Matthias Löhr, Daniel Globisch   +6 more
wiley   +1 more source

The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive‐Like Behavior in Mice

Brain and Behavior, Volume 16, Issue 7, July 2026.
Repetitive transcranial magnetic stimulation (rTMS) ameliorates chronic unpredictable mild stress (CUMS)‐induced depressive‐like behaviors in mice by modulating key tryptophan metabolism pathways, as evidenced by the restoration of serotonin levels and reduction of neuroactive metabolites.
Gao Yuan, Wang Zihao, Leng Yujia, Luan Rongrong, Zhao Xin, Yang Juanini, Liu Junchang, Feng Yuchao, Wang Peng   +8 more
wiley   +1 more source

Boosting Serotonin Synthesis Is Not Sufficient to Improve Motor Coordination of Mecp2 Heterozygous Mouse Model of Rett Syndrome

Biomolecules
Motor deficit is a core symptom of Rett syndrome, a rare neurological disease caused in most cases by mutations of the methyl-CpG-binding protein2 (MECP2) gene. Serotonin reuptake inhibitors improve motor coordination in Mecp2 heterozygous (Het) mice and
Claudia Villani, Giuseppina Sacchetti, Roberto W. Invernizzi   +2 more
doaj   +1 more source

An Overview of Neuroendocrine Tumour Markers

Endocrinology Research and Practice, 2014
As there are many different subtypes of neuroendocrine tumors (NETs), many kinds of markers are used for their diagnosis and follow-up. Most of these markers, such as calcitonin, catecholamines, 5-hydroxyindoleacetic acid (5-HIAA), insulin, gastrin ...
Ersin Özaslan, Halit Diri, Halit Karacan, Yasin Şimşek, Fahri Bayram   +4 more
doaj   +1 more source

Aging Enhances Serotonergic Signaling via 5‐HT7 Receptors Underlying Mechanical Alloknesis

Aging Cell, Volume 25, Issue 7, July 2026.
Aging selectively enhances mechanical alloknesis. This is associated with altered systemic serotonin homeostasis and increased 5‐HT7 receptor expression in dorsal root ganglion neurons and spinal dorsal horn (laminae III–IV). Pharmacological inhibition of serotonergic signaling attenuates itch behavior.
Qiaofeng Zhao, Alberto Leguina‐Ruzzi, Mitsutoshi Tominaga, Yayoi Kamata, Atsuko Kamo, Huiying Wan, Bin Yin, Yuping Ran, Kenji Takamori   +8 more
wiley   +1 more source

Metabolic Fingerprinting of Urine Reveals Metabolite Changes in Women With Breast Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
This study uses metabolomics to compare urine, plasma and serum metabolite profiles across breast cancer, benign breast disease, symptomatic and healthy controls. Significant metabolic differences—especially in amino acids—were found between BC and other groups, with moderate correlations across biofluids, suggesting potential for non‐invasive BC ...
Nur Aimi Aliah Zainurin, Anuradha U. K. H. Bambarandhage, Michelle Moreno Escalona, Dimitra Ivanova, Tim Gate, Helen Tench, Manfred Beckman, Helen Phillips, Mandana Pennick, Luis A. J. Mur   +9 more
wiley   +1 more source

The Relationship of C Fiber to 5-hydroxytryptamine in Spinal Cord of Rat in Electroacupuncture Analgesia

针刺研究, 1996
By using spectrofluophotometry, it was observed that electroacupunture at "Huantiao"points of rat could derease the content of 5-hydroxytryptamine(5-HT)and increase the content of 5-hydroxyindoleacetic acid(5-HIAA)in spinal cord.However ,the above ...
王力萍, 李肇春, 关新民
doaj  

Role of Tryptophan in Microbiota-Induced Depressive-Like Behavior: Evidence From Tryptophan Depletion Study

Frontiers in Behavioral Neuroscience, 2019
During the past decade, there has been a substantial rise in the knowledge about the effects of gut microbiota on host physiology and behavior, including depressive behavior.
Iva Lukić, Dmitriy Getselter, Omry Koren, Evan Elliott   +3 more
doaj   +1 more source

The role of hydroxyindoles in protecting neuronal cultures from ferroptosis

Cell Death Discovery
Hydroxyindoles are organic compounds characterized by a hydroxyl group attached to an indole ring. One notable example is 5-hydroxyindole, which can be found in humans, plants, and microorganisms. The structure of 5-hydroxyindole is integral to molecules
Md. Jakaria, Jason R. Cannon
doaj   +1 more source

A Method For Quantitative Extraction of Urinary 5-Hydroxyindoleacetic Acid

Clinical Chemistry, 1964
Abstract A method for the quantitative assay of urinary 5-hydroxyindoleacetic acid (5 HIAA) is presented. The limits of accuracy and precision obtained reflect good recovery and reproducibility. The relatively high recovery is largely due to maintaining a low distribution coefficient of 5-HIAA during purification of the aqueous extract ...
openaire   +2 more sources