Results 61 to 70 of about 7,469 (209)

A-103 Stability Study of the Biogenic Amines 5-Hydroxyindoleacetic Acid (5-HIAA), Vanillylmandelic Acid (VMA), and Homovanillic Acid (HVA) in Acidified Vs Non-acidified Human Urine Samples [PDF]

, 2023
Lovaco Castellano F, B F Paulo, Danielle Alves Gomes Zauli   +2 more
openalex   +1 more source

FMT intervention decreases urine 5-HIAA levels: a randomized double-blind controlled study

Frontiers in Medicine
BackgroundAutism spectrum disorder (ASD) is often linked to gastrointestinal issues and altered serotonin metabolism. Emerging evidence suggests gut microbiota influence both, with fecal microbiota transplantation (FMT) offering a potential therapeutic ...
Lihong Wang, Lianhu Yu, Zhiyue Liu, Chao Che, Yu Wang, Yongheng Zhao, Mengna Zhu, Guang Yang, Aihua Cao   +8 more
doaj   +1 more source

Efficacy of Acupuncture in Alleviating Negative Emotions in Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 15, Issue 12, December 2025.
This meta‐analysis of seven RCTs (n = 489) demonstrates that acupuncture significantly improves depression scores, hirsutism, and BMI in PCOS patients, though anxiety symptoms show no significant improvement. Evidence quality is low, warranting cautious interpretation. ABSTRACT Introduction Preliminary studies have indicated that acupuncture may play a
Lanfeng Lai, Zhennan Wu, Jiayi Zhao, Jiahuan Li, Boxiong Wu, Han Yang, Nenggui Xu, Wei Yi   +7 more
wiley   +1 more source

Role of Tryptophan Metabolism in Cancer

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review systematically summarizes the functions and related mechanisms of tryptophan metabolism in various tumor types. It presents the latest progress in this field in a comprehensive manner and combines this with clinical practice to offer a new perspective on tumor treatment.
Zhehao Cui, Dandan Wang, Ye Zhang, Long Yuan, Yi Zhang, Xiaowei Qi   +5 more
wiley   +1 more source

The correlation between urinary 5-hydroxyindoleacetic acid and sperm quality in infertile men and rotating shift workers

Reproductive Biology and Endocrinology, 2010
Background Serotonin is a neurotransmitter that modulates a wide range of neuroendocrine functions. However, excessive circulating serotonin levels may induce harmful effects in the male reproductive system.
Pariente José A, García Juan F, Lozano Graciela M, Monllor Fabián, Bejarano Ignacio, Espino Javier, Ortiz Águeda, Rodríguez Ana B   +7 more
doaj   +1 more source

Generation of Pseudo Metabolites as a Side Reaction in On‐Tissue Chemical Derivatization in Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Chemistry–Methods, Volume 5, Issue 12, November 2025.
On‐tissue chemical derivatization reagents enhance sensitivity and specificity, but the impact of side reactions remains understudied. The reactive matrix FMP‐10 promotes Mukaiyama‐like condensation reactions between endogenous metabolites to form pseudo metabolites that are structurally identical to endogenous metabolites.
Tobias Bausbacher, Alessa L. Henneberg, Stephanie Meyer, Stefan Schmidt, Aubry K. Miller, Christiane A. Opitz, Carsten Hopf   +6 more
wiley   +1 more source

Boosting Serotonin Synthesis Is Not Sufficient to Improve Motor Coordination of Mecp2 Heterozygous Mouse Model of Rett Syndrome

Biomolecules
Motor deficit is a core symptom of Rett syndrome, a rare neurological disease caused in most cases by mutations of the methyl-CpG-binding protein2 (MECP2) gene. Serotonin reuptake inhibitors improve motor coordination in Mecp2 heterozygous (Het) mice and
Claudia Villani, Giuseppina Sacchetti, Roberto W. Invernizzi   +2 more
doaj   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li, Fangfang Li, Yang Tang, Siyu Guo, Yihan Yao, Yuan Fang, Bicheng Zhang, Yu Jiang, Jing Wang, Dang Wu, Jianxia Cheng, Zhihui Huang, Zengfeng Xin, Ting Zhang   +13 more
wiley   +1 more source

Tryptophan derivatives as non‐invasive diagnostic indicators for obesity‐related MASLD in children and adolescents

Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 7544-7560, December 2025.
Abstract Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a major health burden in children and adolescents with obesity. This study aimed to characterize metabolic alterations associated with obesity‐related MASLD and to evaluate the potential of tryptophan (TRP)‐derived metabolites as non‐invasive biomarkers for early ...
Shumin Zhan, Xingyun Wang, Chen Wang, Bowen Zhu, Jianfang Gao, Zhou Peng, Rui Wang, Yun Yang, Liang Zhang, Tengfei Wang, Jiaoxiang Wu, Wei Wu, Ke Huang, Guanping Dong, Qiannan Ren, Shan Wang, Senjie Wang, Xuelian Zhou, Liling Xu, Junfen Fu, Xirong Guo   +20 more
wiley   +1 more source

Renal Handling of 5-Hydroxyindoleacetic Acid in the Dog.

Experimental Biology and Medicine, 1965
SummaryThe renal clearance of 5-HIAA at low plasma concentrations in the dog averaged 143 ± 7.8 ml/min/M2 with simultaneous creatinine and sodium iodohippurate I131 clearances of 66 ± 3.6 and 223 ± 20 ml/min/M2, respectively. Probenecid administration resulted in a marked depression of the 5-HIAA clearance.
M E, Kahil, E L, Simons, J, Cashaw, H, Brown   +3 more
openaire   +2 more sources