Results 131 to 140 of about 12,448,100 (233)

5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary [PDF]

, 2012
5-Methylcytosine (5-mC) is an epigenetic modification associated with gene repression. Recent studies demonstrated that 5-mC can be enzymatically oxidised into 5-hydroxymethylcytosine and further into 5-formylcytosine (5-fC) and 5-carboxylcytsine (5-caC).
Abakir, Abdulkadir, Alioui, Anthony, Ferjentsik, Zoltan, Johnson, Andrew D., Ruzov, Alexey, Wheldon, Lee M.   +5 more
core   +2 more sources

Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation [PDF]

, 2014
5-hydroxymethylcytosine (5-hmC) is a novel DNA modification that is highly enriched in the adult brain and dynamically regulated by neural activity. 5-hmC accumulates across the lifespan; however, the functional relevance of this change in 5-hmC and ...
Baker-Andresen, D., Bredy, T. W., D'Alessio, Ana, Flavell, C. R., Li, X., Wei, W., Widagdo, J., Zhang, Yi, Zhao, Q.-Y.   +8 more
core   +3 more sources

Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine

Science, 2013
Epigenetic Controls Germ cells in mammals give rise to sperm and eggs. During their development, germ cells undergo extensive epigenetic reprogramming, including global DNA demethylation, which is vital for the totipotency of the developing embryo ...
Jamie A. Hackett, Roopsha Sengupta, J. J. Żylicz, K. Murakami, Caroline Lee, T. Down, M. Surani   +6 more
semanticscholar   +1 more source

5-Formylcytosine can be a stable DNA modification in mammals. [PDF]

, 2015
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using ...
Adele Murrell, CG Spruijt, CX Song, CX Song, D Cortázar, D Globisch, EA Raiber, F Neri, Heather E Burgess, M Bachman, M Iurlaro, M Tahiliani, M Yu, Mario Iurlaro, Martin Bachman, MG Goll, MJ Booth, MJ Booth, QL Ying, S Cortellino, S Ito, S Kriaucionis, S Schiesser, Santiago Uribe-Lewis, Shankar Balasubramanian, SK Ooi, T Pfaffeneder, Wolf Reik, X Hu, X Lu, Xiaoping Yang, YF He   +31 more
core   +3 more sources

Label-Free and Immobilization-Free Electrochemical Magnetobiosensor for Sensitive Detection of 5-Hydroxymethylcytosine in Genomic DNA.

Analytical Chemistry, 2019
DNA 5-hydroxymethylcytosine (5-hmC) is an important epigenetic biomarker for tumorigenesis, and the loss of 5-hmC levels is associated with leukemia and melanoma cancers. However, it is a great challenge to discriminate 5-hmC from 5-methylcytosine (5-mC)
Lin Cui, Juan Hu, Meng Wang, Chen-chen Li, Chun-yang Zhang   +4 more
semanticscholar   +1 more source

Profiling of oxBS-450K 5-hydroxymethylcytosine in human placenta and brain reveals enrichment at imprinted loci

Epigenetics, 2018
DNA methylation (5-methylcytosine, 5 mC) is involved in many cellular processes and is an epigenetic mechanism primarily associated with transcriptional repression.
Jose Ramon Hernandez Mora, Marta Sanchez-Delgado, Paolo Petazzi, Sebastian Moran, Manel Esteller, Isabel Iglesias-Platas, David Monk   +6 more
doaj   +1 more source

Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas. [PDF]

, 2017
International ...
Bernard, O.A., Bruneau, J., Cairns, R.A., Couronné, L., de Leval, L., Dupuy, A., Fataccioli, V., Gaulard, P., Lemonnier, F., Mak, T.W., Martin, N., Poullot, E., Scourzic, L.   +12 more
core   +2 more sources

Epigenetic Regulations in Neural Stem Cells and Neurological Diseases

Stem Cells International, 2018
Among the regulatory mechanisms of the renewal and differentiation of neural stem cells, recent evidences support that epigenetic modifications such as DNA methylation, histone modification, and noncoding RNAs play critical roles in the regulation on the
Hang Zhou, Bin Wang, Hao Sun, Xingshun Xu, Yongxiang Wang   +4 more
doaj   +1 more source

Effect of cadmium on cytosine hydroxymethylation in gastropod hepatopancreas [PDF]

, 2017
5-Hydroxymethylcytosine (5hmC) is an important, yet poorly understood epigenetic DNA modification, especially in invertebrates. Aberrant genome-wide 5hmC levels have been associated with cadmium (Cd) exposure in humans, but such information is lacking ...
A Garcia, A Gomot, A Itziou, A Itziou, A Murata, A Sanders, ATSDR, B Wang, C Zhang, CJ Pirola, Cristina Popescu, CW Hanna, D Globisch, D Strepetkaite, DJ Spurgeon, Dragos Nica, DV Nica, E Hödl, EM Rasmussen, European Comission, F Gimbert, F Gimbert, F Hispard, F Lyko, F Pierron, G Jiang, G Riviere, George Draghici, H Wang, I Feliciello, Ionela Privistirescu, J Liu, J Zhang, JA Head, Jörg Oehlmann, LK Russell, LL Moroz, LL Moroz, M Coeurdassier, M Höckner, M Notten, M Takiguchi, M Tellez-Plaza, Marek Wojciechowski, Maria Suciu, MB Hossain, MP Kerney, MR Branco, P Cingolani, PA Jones, PE Baurand, PW Hill, R Dallinger, R Dallinger, R Dallinger, R Dallinger, R Kucharski, R Laskowski, RD Hood, Reinhard Stöger, RM Erdmann, S Fneich, S Lian, S Pells, S Wattanaphansak, T Dao, W Li, WB Rabitsch, Y Bergman, Òscar Palacios   +69 more
core   +2 more sources

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. [PDF]

, 2015
Contrary to the long-held belief that DNA methylation of terminally differentiated cells is permanent and essentially immutable, post-mitotic neurons exhibit extensive DNA demethylation.
Coppola, Giovanni, Gao, Fuying, Geschwind, Daniel H, Guo, Junjie U, Ming, Guo-li, Shin, Jaehoon, Song, Hongjun, Su, Yijing, Weng, Yi-Lan, Yu, Huimei, Zhong, Chun   +10 more
core