Results 141 to 150 of about 12,448,100 (233)

Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution.

Journal of the American Chemical Society, 2018
High-resolution detection of genome-wide 5-hydroxymethylcytosine (5hmC) sites of small-scale samples remains challenging. Here, we present hmC-CATCH, a bisulfite-free, base-resolution method for the genome-wide detection of 5hmC.
H. Zeng, Bo He, B. Xia, Dongsheng Bai, Xingyu Lu, Jia-Bin Cai, Lei Chen, Ankun Zhou, Chenxu Zhu, Haowei Meng, Yun Gao, Hongshan Guo, Chuan He, Qing Dai, C. Yi   +14 more
semanticscholar   +1 more source

5-Hydroxymethylcytosine: A stable or transient DNA modification?

Genomics, 2014
The DNA base 5-hydroxymethylcytosine (5hmC) is produced by enzymatic oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is recognized poorly by DNA methyltransferases, DNA methylation may be lost at 5hmC sites during DNA replication.
Hahn, Maria A., Szabó, Piroska E., Pfeifer, Gerd P.   +2 more
openaire   +2 more sources

Ten-eleven Translocation-2 Regulates DNA Hydroxymethylation Status and Psoriasiform Dermatitis Progression in Mice

Acta Dermato-Venereologica, 2018
Epigenetics plays an important role in the development and progression of many diseases. There is increasing evidence for the importance of epigenetic modifications in the progression of psoriasis.
Xin Wang, Xinxin Liu, Xiaoru Duan, Ke Zhu, Song Zhang, Lu Gan, Nian Liu, Himanshu Jaypaul, Johanna T. Makamure, Zhangyin Ming, Hongxiang Chen   +10 more
doaj   +1 more source

5'-Methylcytosine and 5'-hydroxymethylcytosine each provide epigenetic information to the mouse zygote.

PLoS ONE, 2013
Covalent modification of cytosine nucleotides within the genome encode essential epigenetic information, with methylation (5meC) and hydroxymethylation (5hmC) having received most attention.
Yan Li, Chris O'Neill
doaj   +1 more source

Is 5-Hydroxymethylcytosine a Suppressor or Activator in Epigenetic Marks? [PDF]

, 2013
poster abstractAlcohol has been observed to have teratogenic effects on humans and mice during different stages of embryonic development. These effects can be condensed under fetal alcohol spectrum disorder (FASD), exhibiting a variety of signs from ...
Chen, Yuanyuan, Watkins, Darryl S., Zhou, Feng C.   +2 more
core  

Comprehensive mapping of 5-hydroxymethylcytosine epigenetic dynamics in axon regeneration

Epigenetics, 2017
In contrast to central nervous system neurons, dorsal root ganglia (DRG) neurons can switch to a regenerative state after peripheral axotomy. In a screen for chromatin regulators of the regenerative responses in this conditioning lesion paradigm, we ...
Yong-Hwee Eddie Loh, Andrew Koemeter-Cox, Mattéa J. Finelli, Li Shen, Roland H. Friedel, Hongyan Zou   +5 more
doaj   +1 more source

Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques [PDF]

, 2017
The epigenetic modification of 5-hydroxymethylcytosine (5hmC) is receiving great attention due to its potential role in DNA methylation reprogramming and as a cell state identifier.
Dunican, Donncha S., Hunter, Jennifer M., Meehan, Richard R., Moggs, Jonathan G., Nestor, Colm E., Terranova, Rémi, Thomson, John P.   +6 more
core  

Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors

Epigenetics, 2017
Environmental stress contributes to the development of psychiatric disorders, including posttraumatic stress disorder and anxiety. While even acute stress alters gene expression, the molecular mechanisms underlying these changes remain largely unknown. 5-
Ligia A. Papale, Andy Madrid, Sisi Li, Reid S. Alisch   +3 more
doaj   +1 more source

Hydroxymethylation of DNA [PDF]

, 2014
DNA methylation, an epigenetic mechanism is claimed to play essential roles in development, aging and disease over the past few decades. Cytosines (C) were known to exist in two functional states: unmethylated or methylated (5mC) in the mammalian genome
Rajneesh, Richa, Sinha, Rajeshwar P.
core  

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Science, 2009
Mamta Tahiliani, Kian Peng Koh, Yinghua Shen, W. Pastor, Hozefa S. Bandukwala, Y. Brudno, Suneet Agarwal, L. Iyer, David R. Liu, L. Aravind, A. Rao   +10 more
semanticscholar   +1 more source