Results 151 to 160 of about 12,448,100 (233)
Tet proteins: on track towards DNA demethylation? [PDF]
, 2017 Dynamic DNA methylation is a prerequisite for many developmental processes and maintenance of cellular integrity. In mammals however, mechanisms of active DNA demethylation have for long been elusive.
Véron, Nathalie
core
Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression. [PDF]
, 2016 BackgroundAstronauts are exposed to 56Fe ions that may pose a significant health hazard during and following prolonged missions in deep space. We showed previously that object recognition requiring the hippocampus, a structure critical for cognitive ...
Fareh, Fatema +11 more
core
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
Science, 2009 S. Kriaučionis, N. Heintz
semanticscholar +1 more source
Functional Implications of DNA Methylation in Adipose Biology. [PDF]
, 2019 The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core
Functional analysis of 5-hydroxymethylcytosine
, 2014 Mammalian DNA methylathion is a chemical reaction catalyzed by DNA methyltransferases (DNMTs) and involves the addition of a methyl group from the methyl donor SAM to the carbon 5 position of cytosine (C) in a CpG dinucleotide. Specifically, DNA methylation is essential for normal development and is involved in numerous key mechanisms such as genomic ...
openaire +1 more source
Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution
Nature Biotechnology, 2019 Yibin Liu +9 more
semanticscholar +1 more source
5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer. [PDF]
Commun Med (Lond)Puddu F +16 more
europepmc +1 more source