Results 71 to 80 of about 1,655 (156)

Serotonergic psychedelic 5-MeO-DMT alters plasticity-related gene expression and generates anxiolytic effects in stressed mice

open access: yesMolecular Psychiatry, 2023
Abstract Serotonergic psychedelics have potential therapeutic effects in treating anxiety and mood disorders, often after a single dose, and are suggested to have plasticity-inducing action. One lesser studied psychedelic, the 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), is suggested to have anxiolytic effects yet a comprehensive mechanism of
Margareth Nogueira   +9 more
openaire   +2 more sources

Psilocybin and Ibogaine in Cocaine‐Seeking: Extinction Enhancement Without Relapse Prevention

open access: yesAddiction Biology, Volume 31, Issue 3, March 2026.
Using a preclinical model of cocaine self‐administration, we examined the effects of psilocybin and ibogaine on extinction learning and relapse‐like behaviour. Both compounds, administered during the extinction phase, reduced cocaine seeking, indicating facilitation of extinction learning. However, neither treatment prevented cue‐induced reinstatement.
Isis Rita Anzel Koutrouli   +16 more
wiley   +1 more source

The potential of 5-methoxy-N,N-dimethyltryptamine in the treatment of alcohol use disorder:A first look at therapeutic mechanisms of action [PDF]

open access: yes
Alcohol use disorder (AUD) remains one of the most prevalent psychiatric disorders worldwide with high economic costs. Current treatment options show modest efficacy and relapse rates are high.
Tap, Stephan C.
core   +1 more source

Being Wrong About Personal Transformation

open access: yesEuropean Journal of Philosophy, Volume 34, Issue 1, Page 281-296, March 2026.
Abstract Transformative experiences are thought to change us in different ways. Some transform us epistemically by providing genuinely new, previously unimaginable experiences, while others bring about personal transformation by altering our values. Recent debates on transformative experiences have explored the challenges these experiences pose for ...
Adrian Kind
wiley   +1 more source

The light at the end of the tunnel:Safety and efficacy of 5-MEO-DMT in treatment-resistant depression [PDF]

open access: yes
The research described in this thesis focused on the psychedelic and psychoactive effects of the psychedelic drug Mebufotenin (5-MeO-DMT), as well as its safety and therapeutic efficacy.
Reckweg, Johannes Tobias
core   +2 more sources

Dos efeitos ansiolíticos da 5-MeO-DMT no cérebro e comportamento do camundongo [PDF]

open access: yes, 2022
Anxiety is a worldwide prevalent circuitopathy, in other words, a circuit disorder that substantially affects people's quality of life. To treat it properly, it is necessary to reverse the processes that lead to the malfunctioning of neuronal circuits ...
Lima, Margareth de Brito Nogueira
core  

Bridging Scales in Flexible Perovskite Solar Cells: Mechanisms, Interfaces, and Applications

open access: yesAdvanced Science, Volume 13, Issue 12, 27 February 2026.
This perspective focuses on the advancement of flexible perovskite solar cells (f‐PSCs) from the energetic point of view, and summarizes the mechanisms, material characteristics, device performance, and failure mechanisms across the microscopic, mesoscopic, and macroscopic scales through mechanical energy dissipation theory.
Yan Wang   +8 more
wiley   +1 more source

Hemp Proteins Conjugated with Green Tea Polyphenol Extract Form De Novo Plant‐Sourced Emulsifiers Suitable for Nanodelivery Systems Bearing Lipophilic Psychopharmaceuticals

open access: yesAdvanced Therapeutics, Volume 8, Issue 11, November 2025.
Green tea polyphenols, conjugated either covalently or non‐covalently to hemp protein, comprise an excellent stabilizing matrix for oxidatively‐sensitive small molecules. These nanoemulsions are highly stable to a variety of chemical and physical stressors, protecting the small molecule while allowing for easy uptake across cell membranes and rapid ...
William Charles Hosie   +9 more
wiley   +1 more source

Ayahuasca: il vino dell'anima [PDF]

open access: yes, 2015
Ayahuasca in lingua Quechua viene tradotto come Aya, anima, spirito, antenato o persona defunta; huasca liana, corda; significa perciò “liana dei morti”.
Andrea, Ossato   +2 more
core  

Origin and characterization of cyclodepsipeptides: Comprehensive structural approaches with focus on mass spectrometry analysis of alkali‐cationized molecular species

open access: yesMass Spectrometry Reviews, Volume 44, Issue 6, Page 1013-1098, November/December 2025.
Abstract Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds.
Sophie Liuu   +10 more
wiley   +1 more source

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