Results 161 to 170 of about 29,834 (207)
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5-Methylcytosine in Eukaryotic DNA
Science, 1981A small portion of the cytosine residues in the DNA of higher eukaryotes as well as in that of many lowe eukaryotes if methylated. The resulting 5-methylcytosine residues occur in specific in the DNA, usually adjacent to guanine residues on the 3' side.
M, Ehrlich, R Y, Wang
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5-Methylcytosine RNA Methylation in Arabidopsis Thaliana [PDF]
Molecular Plant, 2017 5-Methylcytosine (m5C) is a well-characterized DNA modification, and is also predominantly reported in abundant non-coding RNAs in both prokaryotes and eukaryotes. However, the distribution and biological functions of m5C in plant mRNAs remain largely unknown.
Zhe Liang, Lisha Shen, Hao Yu
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Mutation Research - Reviews in Genetic Toxicology, 1990
Methylation of cytosine residues at position 5 is the only known genetically programmed modifica- tion of the bases in vertebrate DNA. 5-Methylcy- tosine (mSC) constitutes - 0.7-3% of the bases of all studied normal vertebrate cells or tissues and is found mostly in CpG dinucleotide sequences (Ehrlich and Wang, 1981; Gama-Sosa ...
Melanie Ehrlich, Xian-Yang Zhang
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Methylation of cytosine residues at position 5 is the only known genetically programmed modifica- tion of the bases in vertebrate DNA. 5-Methylcy- tosine (mSC) constitutes - 0.7-3% of the bases of all studied normal vertebrate cells or tissues and is found mostly in CpG dinucleotide sequences (Ehrlich and Wang, 1981; Gama-Sosa ...
Melanie Ehrlich, Xian-Yang Zhang
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FLUORESCENCE OF 5‐METHYLCYTOSINE
Photochemistry and Photobiology, 1970Abstract— 5‐Methylcytosine and 5‐methyldeoxycytidylic acid are fluorescent in aqueous solution at room temperature and neutral pH. 5‐Methylcytosine, 10‐3M, pH 8.5, 25°C, has a quantum yield of 5 ×10‐4, 5‐Methyldeoxycitydylic acid, 10‐4M, pH 7.5, 20°C, has a quantum yield of 8 × 10‐4. Emission maxima are 2.91 and 2.80μ‐1.
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Photochemical Deamination and Demethylation of 5-Methylcytosine
Chemical Research in Toxicology, 1996Cytosine methylation is believed to play a pivotal role in eucaryotic cellular development as well as in viral latency. We have been investigating chemical mechanisms for the perturbation of methylation patterns, including the effects of ultraviolet radiation. We observed that, upon exposure to UV light, 5-methylcytosine (5mC) was converted to thymine,
E, Privat, L C, Sowers
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The repair of 5-methylcytosine deamination damage
1993The fact that sites of cytosine methylation in DNA are mutagenic hotspots, and that the genome of higher eukaryotes is thus depleted of the modified sequence CpG is common knowledge — certainly in the field of DNA methylation. The reason why 5-methylcytosine is an endogenous mutagen would also appear to be clear: 5-methylcytosine deaminates to thymine,
K, Wiebauer +3 more
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5-Methylcytosine-Rich Heterochromatin in Reptiles
Cytogenetic and Genome Research, 2019An experimental approach using monoclonal anti-5-methylcytosine antibodies and indirect immunofluorescence was elaborated for detecting 5-methylcytosine-rich chromosome regions in reptilian chromosomes. This technique was applied to conventionally prepared mitotic metaphases of 2 turtle species and 12 squamate species from 8 families.
Michael Schmid +7 more
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5-Methylcytosine in Chlorella pyrenoidosa DNAs
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976The presence of 5-methylcytosine in Chlorella pyrenoidosa (strain 211/8b) DNA's has been investigated by means of paper chromatography and thermal chromatography on hydroxyapatite. It has been shown that nuclear DNA contains 3.5 mol% 5-methylcytosine whereas no significant amount of this base can be detected in chloroplast DNA.
M, Bayen, J, Dalmon
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On the mechanism of demethylation of 5-methylcytosine in DNA
Bioorganic & Medicinal Chemistry Letters, 2008DNA methylation is an important biological process that programmes gene expression in vertebrates. The methylation pattern is generated by a combination of methylation and demethylation reactions catalyzed by DNA methyltransferases and putative demethylases. MBD2 binds methylated DNA and possesses DNA demethylase activity.
Stefan, Hamm +5 more
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Identification of 5-Methylcytosine in Complex Genomes
Methods, 1999Cytosine methylation is attracting new attention for regulatory roles in gene expression and there is an increasing interest in detecting, at a single-base resolution, any 5-methylcytosine in genes from complex genomes. Differential base modification by chemicals followed by PCR-based genomic sequencing procedures can provide the resolution ...
H, Thomassin, E J, Oakeley, T, Grange
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