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5-Methylcytosine, Gene Regulation, and Cancer
1983Publisher Summary This chapter focuses on 5-methylcytosine, gene regulation, and cancer. The regulation of mammalian gene expression clearly is accomplished by multiple control systems operating at several levels. Some obvious levels of control include chromosome condensation, chromatin structure transcriptional control by repressors and activators ...
A D, Riggs, P A, Jones
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Organization of 5-methylcytosine in chromosomal DNA
Biochemistry, 1978The 5-methylcytosine residues of L-cells have been labeled with [methyl-3H]-L-methionine and their chromatin localization studied using deoxyribonucleases. The kinetics of micrococcal nuclease digestion showed that the methylated cytosine residues are concentrated within regions resistant to nuclease digestion and preferentially missing from those ...
A, Solage, H, Cedar
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5-Methylcytosine-Selective Osmium Oxidation
Nucleosides, Nucleotides and Nucleic Acids, 2007Methylcytosine was efficiently and easily modified through osmium oxidation. Methylcytosine-selective oxidation is applicable to detection of the cytosine methylation status at a specific site of a long sequence using the formation of a bulge structure by hybridization with a guide DNA.
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Phosphopeptides Designed for 5-Methylcytosine Recognition
Biochemistry, 2011An artificial phosphopeptide has been developed through rational design of the interaction with 5-methylcytosine in duplex DNA. The peptide consists of two tandem zinc finger motifs, in one of which the glutamate was replaced with a phosphotyrosine, the phosphotyrosine in the peptide being effective for methylcytosine selectivity of DNA binding.
Akiko, Nomura, Akimitsu, Okamoto
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5-Methylcytosine Analysis by RNA-BisSeq
20185-Methylcytosine (m5C) is a posttranscriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. Many known or novel m5C sites have been validated by using advanced high-throughput techniques combined with next-generation sequencing (NGS), especially RNA bisulfite sequencing (RNA-BisSeq).
Yu-Sheng, Chen +5 more
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5-Methylcytosine and Its Derivatives
2014Epigenetics has undergone an explosion in the past decade. DNA methylation, consisting of the addition of a methyl group at the fifth position of cytosine (5-methylcytosine, 5-mC) in a CpG dinucleotide, is a well-recognized epigenetic mark with important functions in cellular development and pathogenesis.
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Structure of 5-methylcytosine hydrochloride
Acta Crystallographica Section C Crystal Structure Communications, 1987$C_5H_8N_30^+.C1^ -$, $M_r= 161.6$, monoclinic, $P2_1/c$, a=6.431(1), b=16.132(2), c=7.030(1)A, \beta=97.33(1)°, $V=723.29\AA ^3, Z=4, D_x=1.48, D_ m = 1.49 Mg m^{-3}$, \lambda(Cu Ka) = 1.5418 \AA, \mu = 0.423 $mm^{-1}$, F(000) = 336, T = 295 K, R = 0.042 for 1146 observed reflections with I > 3\rho(I). The cytosine base is protonated at N(3).
Padmaja, N, Ramakumar, S, Viswamitra, MA
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The 5-Methylcytosine in DNA of Rats
Gerontologia, 2009The GC content and amount of 5-methylcytosine (5-MeCyt) have been determined in total DNA from certain organs of male albino rats 1, 12 and 28 months of age. A marked tissue specificity of DNA with respect to the 5-MeCyt content has been revealed. The 5-MeCyt content in DNA decreases with age in the brain, heart and spleen; it does not change in the ...
B.F. Vanyushin +4 more
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DNA repair and erasure of 5‐methylcytosine in vertebrates
BioEssays, 2017DNA methylation plays important roles in development and disease. Yet, only recently has the dynamic nature of this epigenetic mark via oxidation and DNA repair‐mediated demethylation been recognized. A major conceptual challenge to the model that DNA methylation is reversible is the risk of genomic instability, which may come with widespread DNA ...
Lars, Schomacher, Christof, Niehrs
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5-methylcytosine formation in wheat embryo DNA
Biochemical and Biophysical Research Communications, 1980Summary The methylation of cytosine residues in wheat DNA was studied in isolated embryos during the first 30 hrs of germination. L-Methionine, but also L-serine serve as methyl group donors in vivo . DNA methylation reaches high values after the maximum of DNA replication at 18 hrs.
G, Theiss, H, Follmann
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